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View Structure Prediction Details

Protein: Rpn5-PA
Organism: Drosophila melanogaster
Length: 502 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Rpn5-PA.

Description E-value Query
Range
Subject
Range
gi|195146356, gi... - gi|195146356|ref|XP_002014152.1| GL24524 [Drosophila persimilis], gi|194103095|gb|EDW25138.1| GL2452...
gi|54638798|gb|E... - GA10700-PA [Drosophila pseudoobscura], GA10700 [Drosophila pseudoobscura pseudoobscura]
gi|125775764, gi... - gi|54638798|gb|EAL28200.1| GA10700 [Drosophila pseudoobscura pseudoobscura], gi|125775764|ref|XP_001...
350.0 [0..1] [502..1]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTYLFDGGR ITKMEVDYEP ACNEKIPLAK ELAKKNPDAF HEAIEMMLQL EKQTRLGADM  60
   61 VSCSRVLVAI CQICFDASNW NALNEYVSLL VRRRSQLKQA VVKMIQECVT YVDKTPDKET 120
  121 KLKLIDTLRS VTEGKIYVEI ERARLTKILA DIKEADGDVA GAATVMEELQ VETYGSMDKR 180
  181 EKVELILEQM RLCLLKEDYV STQIIAKKIS IKFFD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [216-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPAQHDLKLK FYYLMIQLNR DTSFLNTSRH YQAIAEPPRK KTGLTPVDSA ASTDEQKKKD  60
   61 DDKKKKEEDD KDKKPEVATE AEVEIELTEE QKKELTEKLV CAVLYCVLAP FDNEQSDMMA 120
  121 HLSKNKKLEE VPAYKEILRL FMSKELINFD TFNADFGLVL AENEMF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [382-502]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDSTKHGKKC ITELKDRLIE HNIRIIAMYY SRLHLARMSE LLNLPTSRCE EYLSKLANTD  60
   61 TIRVKIDRPA GIIYFTQKKS ASDILNNWAT DVNQLMSLVN KTCHLINKEE CVYSVMCAVE 120
  121 D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.045757
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.69037212939381 bayes_pls_golite062009
nucleic acid binding 2.51073261475907 bayes_pls_golite062009
transcription regulator activity 2.46972120642276 bayes_pls_golite062009
DNA binding 2.34739506178536 bayes_pls_golite062009
hydrolase activity 2.30467124306022 bayes_pls_golite062009
transcription factor activity 1.63630978976366 bayes_pls_golite062009
protein binding 0.653872239015235 bayes_pls_golite062009
sequence-specific DNA binding 0.42089068572633 bayes_pls_golite062009
transcription activator activity 0.177144423226603 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.136726704233672 bayes_pls_golite062009
small conjugating protein ligase activity 0.118016217031359 bayes_pls_golite062009
transcription repressor activity 0.0832641811501794 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle