YRC Public Data Repository - Protein Structure Prediction

Protein:	CG13890-PA
Organism:	Drosophila melanogaster
Length:	262 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG13890-PA.

Description	E-value	Query Range	Subject Range
gi\|20807045, gi\|... - gi\|20807045\|ref\|NP_622216.1\| 3-hydroxybutyryl-CoA dehydratase [Thermoanaerobacter tengcongensis MB4]... gi\|20807045 - gi\|20807045\|ref\|NP_622216.1\| enoyl-CoA hydratase [Thermoanaerobacter tengcongensis MB4]	292.0	[0..4]	[261..1]
gi\|28204455, gi\|... - gi\|28212012\|ref\|NP_782956.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium tetani E88], gi\|28204455\|...	290.0	[0..4]	[258..1]
gi\|70606884, gi\|... - gi\|70606884\|ref\|YP_255754.1\| 3-hydroxybutyryl-CoA dehydrogenase [Sulfolobus acidocaldarius DSM 639],...	285.0	[0..5]	[261..407]
gi\|1903327 - gi\|1903327\|emb\|CAB07495.1\| crotonase [Thermoanaerobacterium thermosaccharolyticum] gi\|1903327\|emb\|C... - crotonase [Thermoanaerobacterium thermosaccharolyticum]	284.0	[0..4]	[261..1]
gi\|15920248, gi\|... - gi\|15920248\|ref\|NP_375917.1\| 3-hydroxybutyryl-CoA dehydrogenase [Sulfolobus tokodaii str. 7], gi\|156...	284.0	[0..7]	[261..398]
gi\|241218800, gi... - gi\|241769557\|ref\|ZP_04766976.1\| Enoyl-CoA hydratase/isomerase [Sulfolobus solfataricus 98/2], gi\|241... gi\|25291790 - pir\|\|A90436 enoyl CoA hydratase (paaF-7) [imported] - Sulfolobus solfataricus gi\|13815932, gi\|... - gi\|15899349\|ref\|NP_343954.1\| enoyl CoA hydratase (paaF-7) [Sulfolobus solfataricus P2], gi\|13815932\|...	282.0	[0..6]	[261..9]
gi\|88926146, gi\|... - gi\|88944140\|ref\|ZP_01147473.1\| putative crotonase [Desulfotomaculum reducens MI-1], gi\|88926146\|gb\|E...	282.0	[0..4]	[261..1]
gi\|18145966, gi\|... - gi\|18311283\|ref\|NP_563217.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens str. 13], gi\|... gi\|110673862, gi... - gi\|110799215\|ref\|YP_696975.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens ATCC 13124],... gi\|182625533, gi... - gi\|182625533\|ref\|ZP_02953304.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens D str. JGS... gi\|170715197, gi... - gi\|170715197\|gb\|EDT27379.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens CPE str. F4969...	281.0	[0..4]	[261..1]
gi\|110683900, gi... - gi\|110803399\|ref\|YP_699562.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens SM101], gi\|1...	280.0	[0..4]	[261..1]
gi\|116062799, gi... - gi\|118431474\|ref\|NP_147973.2\| 3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA dehydratase [Aero...	278.0	[0..7]	[261..414]

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Predicted Domain #1

Region A:
Residues: [1-262]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTYQGYKELL VEQQGKLLVA KFNNPKKKNC INRVAYQEMT RVLTEVNDDE GVTIVVFTGV  60
   61 GDIFTSGNDL SQSSNTDDID AFFKQSNATF KAMVLSFVNC RKIVLALVNG PAIGIGATIV 120
  121 GLCDVAWCSE TTYFYTPFTK LGLVPEGGSS YMLPLILGRS KASEILLLSE PLSAQEAYQF 180
  181 NFVSRIFKAS ELESVIWPKL RQYSELPTNS LLQGKRLVKD GFLENLIKAN EAECKQLLQQ 240
  241 FQHPEFAQAI IDFASRKNKA KL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.221849
Match:	2f6qA
Description:	The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-hydroxyacyl-CoA dehydrogenase activity	4.25084649365698	bayes_pls_golite062009
enoyl-CoA hydratase activity	3.92947460544831	bayes_pls_golite062009
CoA carboxylase activity	3.59076614105466	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	3.4980371783229	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.34692152434862	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing C=C bonds	1.97586838275054	bayes_pls_golite062009
dodecenoyl-CoA delta-isomerase activity	1.80820904754223	bayes_pls_golite062009
catalytic activity	1.46154163027498	bayes_pls_golite062009
3-hydroxybutyryl-CoA epimerase activity	1.31614278936637	bayes_pls_golite062009
propionyl-CoA carboxylase activity	1.20853698666984	bayes_pls_golite062009
racemase and epimerase activity, acting on hydroxy acids and derivatives	1.08284170936757	bayes_pls_golite062009
long-chain-3-hydroxyacyl-CoA dehydrogenase activity	1.03484393216342	bayes_pls_golite062009
ligase activity	0.98581896521131	bayes_pls_golite062009
long-chain-enoyl-CoA hydratase activity	0.571617594666499	bayes_pls_golite062009
binding	0.222808057179506	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: