YRC Public Data Repository - Protein Structure Prediction

Protein:	CG10306-PA
Organism:	Drosophila melanogaster
Length:	222 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG10306-PA.

Description	E-value	Query Range	Subject Range
gi\|125807345, gi... - gi\|54635542\|gb\|EAL24945.1\| GA15733-PA [Drosophila pseudoobscura], gi\|125807345\|ref\|XP_001360370.1\| G...	351.0	[0..1]	[222..1853]
EIF3K - eukaryotic translation initiation factor 3, subunit K gi\|114676993 - gi\|114676993\|ref\|XP_512639.2\| PREDICTED: eukaryotic translation initiation factor 3, subunit 12 [Pan... gi\|109124583 - gi\|109124583\|ref\|XP_001082764.1\| PREDICTED: similar to eukaryotic translation initiation factor 3, s...	342.0	[0..13]	[219..9]
tr\|M3WUN8\|M3WUN8... - Eukaryotic translation initiation factor 3 subunit K OS=Felis catus GN=EIF3K PE=3 SV=1 EIF3K_BOVIN - Eukaryotic translation initiation factor 3 subunit K OS=Bos taurus GN=EIF3K PE=2 SV=1 gi\|149722101 - gi\|149722101\|ref\|XP_001497262.1\| PREDICTED: similar to eukaryotic translation initiation factor 3, s... gi\|57036583 - gi\|57036583\|ref\|XP_533679.1\| PREDICTED: similar to eukaryotic translation initiation factor 3, subun...	341.0	[0..13]	[219..9]
EIF3K_MOUSE - Eukaryotic translation initiation factor 3 subunit K OS=Mus musculus GN=Eif3k PE=1 SV=1	339.0	[0..13]	[219..9]
gi\|149056429, gi... - gi\|27730981\|ref\|XP_214886.1\| PREDICTED: similar to eukaryotic translation initiation factor 3, subun...	338.0	[0..13]	[219..9]
EIF3K_XENLA - Eukaryotic translation initiation factor 3 subunit K OS=Xenopus laevis GN=eif3k PE=2 SV=1	322.0	[0..13]	[219..9]
EIF3K_XENTR - Eukaryotic translation initiation factor 3 subunit K OS=Xenopus tropicalis GN=eif3k PE=2 SV=1	322.0	[0..13]	[219..9]

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Predicted Domain #1

Region A:
Residues: [1-222]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHLVKMENG QSQTIQEMLG CIERYNPDHL KTLESYVQDQ AKNNTYDLEA NLAVLKLYQF  60
   61 NPHMLNFDIT YTILLKSLTS LPHTDFVMAK CLLLPQQMKD ENVQTIIDLA DILERADFTL 120
  121 FWQRAEVNRN MFRHITGFHD SIRKFVSHVV GTTFQTIRKD LLKELLGGIE DSTLESWIKR 180
  181 NGWKNQGQGL VIVAMQDDKI KTKNITEKIE FDNVGALMAQ CL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	94.0
Match:	1rz4A
Description:	Crystal Structure of Human eIF3k
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	4.65136805471804	bayes_pls_golite062009
binding	2.27902748675387	bayes_pls_golite062009
protein binding	1.94427330399472	bayes_pls_golite062009
RNA cap binding	1.73309326409609	bayes_pls_golite062009
sequence-specific DNA binding	0.93130370844712	bayes_pls_golite062009
structural molecule activity	0.908029258648777	bayes_pls_golite062009
nucleic acid binding	0.856241051862415	bayes_pls_golite062009
translation regulator activity	0.82193201542158	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.803700928110921	bayes_pls_golite062009
structural constituent of ribosome	0.742648546865457	bayes_pls_golite062009
transcription repressor activity	0.67795138236883	bayes_pls_golite062009
RNA binding	0.39193569533369	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.10854873707001	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: