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View Structure Prediction Details

Protein: NC2alpha-PA
Organism: Drosophila melanogaster
Length: 341 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NC2alpha-PA.

Description E-value Query
Range
Subject
Range
gi|10242351, gi|... - gi|21430234|gb|AAM50795.1| LD24434p [Drosophila melanogaster], gi|10242351|gb|AAG15389.1| NC2alpha [...
169.0 [0..1] [341..1]

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Predicted Domain #1
Region A:
Residues: [1-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSKKKKYNA RFPAGRIKKI MQSDEEIGKV AQAVPVIISR TLELFVESLL TKTLRITNAR  60
   61 NAKTLSPSHM RQCIVSEKRF DFLKELVRNI PD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.221849
Match: 1jfiA
Description: Negative cofactor 2, NC2, alpha chain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 6.43582244485566 bayes_pls_golite062009
DNA binding 4.49118409263799 bayes_pls_golite062009
nucleic acid binding 4.35201412176948 bayes_pls_golite062009
transcription regulator activity 4.08606081850613 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.28941584139552 bayes_pls_golite062009
binding 3.27510691458843 bayes_pls_golite062009
transcription factor activity 2.51581622888695 bayes_pls_golite062009
transcription repressor activity 2.3574713307436 bayes_pls_golite062009
transcription initiation factor activity 1.57176056919918 bayes_pls_golite062009
transcription corepressor activity 1.30859203490073 bayes_pls_golite062009
transcription activator activity 1.25487495162413 bayes_pls_golite062009
transcription factor binding 1.15204005455906 bayes_pls_golite062009
transcription coactivator activity 1.1297723528047 bayes_pls_golite062009
protein binding 1.07873333188144 bayes_pls_golite062009
transcription cofactor activity 1.01502031330902 bayes_pls_golite062009
sequence-specific DNA binding 0.0852726470007639 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [93-280]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISVAEEAAYN EDDVLRSSPE EQYPDSDTPY DLSLPSTSMR SQANGTAAYM RSMSLNNGAG  60
   61 SGGGAAATKR QFQSQHSTQE TPTTSTTLPA KLARSGSMPA YTPRGRPPNH LKKQSVQLDT 120
  121 AIPAPICNYE LNKPIVKIDY SHVQMPTANL CTPDASDSGS GSGAGSGAFN FDIAAPVINI 180
  181 DLTNIVAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [281-341]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAPGSGVPPA SIGLPAATPG DNNNVNQMAG KSSAPIIPKA TAASATPTET VFELDEDYDN  60
   61 I

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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