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View Structure Prediction Details

Protein: rib-PA, FBpp0303090
Organism: Drosophila melanogaster
Length: 661 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rib-PA, FBpp0303090.

Description E-value Query
Range
Subject
Range
KLHL2_MOUSE - Kelch-like protein 2 OS=Mus musculus GN=Klhl2 PE=1 SV=1
194.0 [0..2] [315..13]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGPTAPVAS SGEVGQTYCL RWNNHQTNLV QILHALHEVG SYVDCSLVVD DEQFQAHRVV  60
   61 LAANSPYFQH ILKDVPQDHC SIILPGVKGF EIAALLQYMY TGETTVTKSQ EPEILRTAKE 120
  121 LQVKGLYDNL MKFNHASVTP TSSSGAGGAK PQNGSASNHS SSVISTSTHI SPSAAISSSC 180
  181 SPPPPPQFGY 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.522879
Match: 2nn2A
Description: No description for 2nn2A was found.

Predicted Domain #2
Region A:
Residues: [191-327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPGYSHYPQQ QPMSASQIPA GEAPLTPTQA TPHSAASGAG EAGGQWPLTP SAAAAMLNSV  60
   61 YESAADMNPL KRKKLSAISS MLLSGNRDTP ILRNVLAQAN PADSSQPGPM NANGEKTPTH 120
  121 PHQNTQLPAG LGVSGGE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [328-425]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNHSFNGSDY GGDKEPLSPY TDRSFEEETG QSGGKKPEWK RYKQYTRADM MCAIQAVREG  60
   61 MSALQASRKY GLPSRTLYDK VRKLNITTGR GTHRTPKR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.14
Match: 2cobA
Description: Solution structures of the HTH domain of human LCoR protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.86538715425734 bayes_pls_golite062009
DNA binding 4.40186699787632 bayes_pls_golite062009
nucleic acid binding 4.28652307290136 bayes_pls_golite062009
transcription factor activity 3.78935192723648 bayes_pls_golite062009
transcription repressor activity 3.3280771187468 bayes_pls_golite062009
sequence-specific DNA binding 3.25454589469681 bayes_pls_golite062009
transcription activator activity 2.92652250400688 bayes_pls_golite062009
binding 2.92574888336072 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.91588376840709 bayes_pls_golite062009
protein binding 1.84594855626241 bayes_pls_golite062009
chromatin binding 1.46954724788757 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.44773725829085 bayes_pls_golite062009
transcription corepressor activity 1.30723796612579 bayes_pls_golite062009
transcription factor binding 1.24678737091956 bayes_pls_golite062009
transcription cofactor activity 0.691780246385357 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [426-527]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPPGAESSQG FSYSAAAAAA AHNYGHGHGH HSEVKRDQKV DHVPAHHGMP PTIPPSAAAL  60
   61 LDHAFLQQAL ENRGGDMAGR EALHAMALAA AAHAAANRLS SS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [528-661]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAEMDQRSNG HGMRSPSPQG RHYPHEQEAM DLEMEKHEQN IIKRERDQDE REDADDEEDH  60
   61 EQEHVEDLSL ARKERPPSPY SPQPTEAGAG VIMHASSASA NGKDHVDYPS SPQFVPIGLK 120
  121 RELMEGEDAQ ARAD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle