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View Structure Prediction Details

Protein: gi|21645323, gi|...
Organism: Drosophila melanogaster
Length: 2403 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|21645323, gi|....

Description E-value Query
Range		 Subject
Range
gi|24653968, gi|... - gi|24653968|ref|NP_725507.1| Stretchin-Mlck, isoform C [Drosophila melanogaster], gi|21645318|gb|AAM...
 1350.0 [0..1] [2398..1]

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Predicted Domain #1
Region A:
Residues: [1-186] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGETENGDIE PRASAEPEAA SAQDTLQVPT QKKRKLKSPT PGSLRGRSAT PIHGRSQTPF  60
   61 TLYMTRRSAT PSTWRSITPF LKREEKEKTP FELGRDIKSQ TTCNIAVFDR ALVMDISEPL 120
  121 DVQKPVRYIT SDLSVIDRAA VMDVSNVEVI YVVEEYEEVE EEEIIEEVKP KKKEKKARKP 180
  181 RAQRKS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.09
Match: 2j63A
Description: No description for 2j63A was found.

Predicted Domain #2
Region A:
Residues: [187-310] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDKDMSPSGA EDGDDLGDFG GDDREDSVDL DDGDEPVKKG KKKAPPKKKE KKEKSPSPKL  60
   61 TLKLEIGGGQ KASKKMFEQQ QQQAKPPPKK SKMVLQMEEQ AKAAAKAAEE AAARAKPKGE 120
  121 TFEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [311-443] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQKRLQAEKE EQERLEAEQR AQEEAEAEAE AEAEEDEEDP SNVGEEGEEG TEAGYGDEDQ  60
   61 EQEYPEDEIE AEPEEDTKKK EKRRGSDSSD DFVRPDPHEE ERWQRIAAVE GEEFMQQMRK 120
  121 YSQAKRISEK ERD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [444-658] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADWQRRREQA RNPKFINFLS DRAVEAGQSV RLACAVDGPE LSVKWYHNRK QLERDGCHRI  60
   61 INNNNILVLE VLNTTILDSG EYSCVISNQN DETSSSCIVT IYEIFKDEPK PPSIQYIKEY 120
  121 YHLRDDELTI ECHVHGYPRP VITWWRGCFQ VKPSYKFTML EEAHGVCKLL IYKPGNKDGG 180
  181 IYTMKAINSS GEVQINHTVE VARNLHYHVP GIFHA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.045757
Match: 1z7zI
Description: Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
antigen binding 1.63189745559168 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
protein binding 1.17809977833322 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
myosin heavy chain binding 0.66378995104464 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.6127264879262 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
receptor activity 0.438456574760785 bayes_pls_golite062009
fibroblast growth factor binding 0.0963660533195985 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
transferase activity 0.053007146193305 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [659-1244] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDKIQLDSLK QAKKAMEAAL KSKADSDQRR AEAEEEQARL HPVKATPERL VPAKQKLAFA  60
   61 TQLRDRMALE GSTIKFVATV IGPDPNTRWM KDDKWVVVGG NIKNLSEEGK AILEVGNVTS 120
  121 ADSGVYKCVA KNDLSEIETS CYFKVYAAQA DGDESEPIFA LPLRDVYHAS QNDLILDTKV 180
  181 RGNPRPEISW TKDQIPVVLD DRVVQIEHLD GICELIINKP TINDNGIYVC TAKNKLGSQS 240
  241 TTHTVVVDTT HTSRRSSILS AIAMQEGGGG GESADAKAKG KKKKKEDEPE GGDGGYERRS 300
  301 RMPDPSPKQM LYFTVNLSNR YVAEGSKVKL QAVIGGPQPM IKWLKDDQNV TYGPNIRNMN 360
  361 RDSLAVLEFT NAKVEDSGTY SIVAQNESCK ITTSAMLHVY ETKVNTDVQP VFIRSLKETY 420
  421 HLNTNELILE TAVRGQPTPA VQWFKDSIEI QSGGRFQIIE HQDGTCELII DRPDNKDSGK 480
  481 YVVKAESRAG KMEISHYVLF EGQSHHIAEN IHGVFHADKS LLRPKEVEKP VEKKPAPAAE 540
  541 PESEAEDGKA KRRAKKEEDD GASSAYATDY ASDTASLSSK RREKNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.522879
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1245-1441] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AIHFSTSMRD RVVAEGSKVK ISCFLEAKEP QVKWFKDGEQ IQNSPKIRGR YSEGLCLLEV  60
   61 MSATAEDNGE YKCWGRDETG EASTSCRLEV YENPGTGDVP PTFTRNIKDT MHGKINELQL 120
  121 DVHVRGLPTP AVTWVKDGVK IENSDKYQQV DHDDGTCELF ISRPKASDSG KYVCQAENRE 180
  181 GKTEIVHMIT VEPRVRA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.0
Match: 1bihA
Description: Hemolin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
antigen binding 1.63189745559168 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
protein binding 1.17809977833322 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
myosin heavy chain binding 0.66378995104464 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.6127264879262 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
receptor activity 0.438456574760785 bayes_pls_golite062009
fibroblast growth factor binding 0.0963660533195985 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
transferase activity 0.053007146193305 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1442-1704] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRISPPREGR PPRPSGDEEP AAAGEEGAEG AADGEGGEKR RRKPKPDEEE QTSSRREVPP  60
   61 PPDLRKRLYF RNFLSNRTVK SGSNVKWMVN IDGPEPTAKW FFGDQPIAFG PRSKMSMQDG 120
  121 IAWLNLVGVT EEDAGEYTLR VRGSENEIVS TCNLFVYSTG KPEVIPPTFV VGIKDAYHSQ 180
  181 GNQLTLECKV SGSPKPHIYW QRDNTLLPIE GTKYQYEEQS DGIKLLTINN FGSNDSGLYT 240
  241 CYAESENGQM KISKFVQASD YVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.045757
Match: 1djsA
Description: Fibroblast growth factor receptor, FGFR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
antigen binding 1.63189745559168 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
protein binding 1.17809977833322 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
myosin heavy chain binding 0.66378995104464 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.6127264879262 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
receptor activity 0.438456574760785 bayes_pls_golite062009
fibroblast growth factor binding 0.0963660533195985 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
transferase activity 0.053007146193305 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [1705-1910] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERIADKKPID KVIQEIKRDE SSSAAANDTA AAKAKAREAK LRLNLETSLK TMTIGSGNKA  60
   61 QLICYVTGII EDVHWLRNDE RVTKDARHKI YNINGAISLE IYDARVEDSG HYRCVVKNSR 120
  121 QTVESAGQLS VLDQSTGKLP ESFSSGIIES YDDQRNEIVL SCQVIGRPSV SWMRDDHSIC 180
  181 NNRYRTIEEP GGVRKLVIRN PISSDC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.0
Match: 1cs6A
Description: Axonin-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
antigen binding 1.63189745559168 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
protein binding 1.17809977833322 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
myosin heavy chain binding 0.66378995104464 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.6127264879262 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
receptor activity 0.438456574760785 bayes_pls_golite062009
fibroblast growth factor binding 0.0963660533195985 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
transferase activity 0.053007146193305 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [1911-1980] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIFACYAEHE DRIDSTSITI KAADLKRLIN VSQEEIPSIG DHESTPWSRS QSHLSSGSQV  60
   61 NGNGELHRAG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.01
Match: 2ch8A
Description: No description for 2ch8A was found.

Predicted Domain #10
Region A:
Residues: [1981-2256] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRVLRNVGKG KPLFHTLLHD RTVSEGANLR LVCSVSGDEN THIEWLKNHK PLPRSDNRYQ  60
   61 TVYLNGEASL EIFAAVADDS GNYTCCATND FGESLTHAQL RVYKNFKEAP LPSTFTQPIR 120
  121 DTYSLNENEL VLDCRVRGQP RPEIQWIKGT EPIEASEKFK PSDQADGYAK LVIVNPTEKD 180
  181 SGIYWCVARN EGAENKISHQ VDFKGRQHYS LEKTHGFFHR DPNKPHFLLP LGNQTVCNGG 240
  241 TVAISAEFME TSTPIEVKWL RDRRVVDGPN VKALAD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.522879
Match: 1za6B
Description: The structure of an antitumor CH2-domain-deleted humanized antibody
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
antigen binding 1.63189745559168 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
protein binding 1.17809977833322 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
myosin heavy chain binding 0.66378995104464 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.6127264879262 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
receptor activity 0.438456574760785 bayes_pls_golite062009
fibroblast growth factor binding 0.0963660533195985 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
transferase activity 0.053007146193305 bayes_pls_golite062009

Predicted Domain #11
Region A:
Residues: [2257-2403] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGVYTLTIMN AGPEVEGTYT CRASNAFGRI ESNVNVDVAV GAEKDERPPL FLSRPDTEMK  60
   61 IAVGDPFSLS FRIAGDPKPK LTFMKGTKDI TQSDRVSKEV SDDYTRFSVQ QAQISDSGTY 120
  121 FVVARNNFGT DRIFVTVTIK IPKKKEE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.69897
Match: 1ry7B
Description: Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 6.64811984458494 bayes_pls_golite062009
alpha-actinin binding 5.77350124471385 bayes_pls_golite062009
actinin binding 5.69539760434923 bayes_pls_golite062009
structural constituent of muscle 4.93896503565413 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
antigen binding 1.63189745559168 bayes_pls_golite062009
cytoskeletal protein binding 1.58610597245454 bayes_pls_golite062009
actin binding 1.42681407553255 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
nucleic acid binding 1.32330470851159 bayes_pls_golite062009
DNA binding 1.19412627500732 bayes_pls_golite062009
myosin light chain kinase activity 1.17845072849922 bayes_pls_golite062009
protein binding 1.17809977833322 bayes_pls_golite062009
transcription regulator activity 1.16252234499274 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
actin filament binding 0.760856470721016 bayes_pls_golite062009
myosin heavy chain binding 0.66378995104464 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.6127264879262 bayes_pls_golite062009
titin binding 0.599892148302011 bayes_pls_golite062009
structural molecule activity 0.567620977360967 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
transcription factor activity 0.54549168007511 bayes_pls_golite062009
receptor activity 0.438456574760785 bayes_pls_golite062009
fibroblast growth factor binding 0.0963660533195985 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0579247757286607 bayes_pls_golite062009
transferase activity 0.053007146193305 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle