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View Structure Prediction Details

Protein: cbs-PA
Organism: Drosophila melanogaster
Length: 611 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cbs-PA.

Description E-value Query
Range
Subject
Range
gi|68388302 - gi|68388302|ref|XP_696268.1| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]
310.0 [0..4] [597..2237]

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Predicted Domain #1
Region A:
Residues: [1-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFATLKNKIK EETGDDVVQS ANQRYPGNNN NNYRLRSRRV SINSNSADDV GGGGFYNESE  60
   61 QLCELRSQCN ELTTKLSTVT QGLQQLQEEK TRVDKTNEIL LESVRVAQTQ KDIYCEEQEK 120
  121 IQNLQQIEID KLKNLLSFRE QESVDRMGLM RQQTQQIESL SEELERLRPI ESVAEDLRDE 180
  181 LEQLRHSTQQ EKNLLTTTLA AVQEENRHLK KRMKIVEESR LESLGKLNSE QQVQALIREH 240
  241 KLLEQHLEEA HLQLSDIKGS WSGQNLALET QVSRLSKQVA EETTEKRKAL KSRDDAIESR 300
  301 KQVSFELEKA KDEIKQRDDK VKLLEEEIDE L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.154902
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [332-453]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVALKECREE NEQQVLFERN KSQNLETEVK DLKTRLTAAD DRFSEYSSNA EQVAQKLRVQ  60
   61 VTEKQEQLDE TIMQLEIERE EKMTAILRNA EIAQSEDILR QQLRLERSEA SDLQERNNQL 120
  121 VR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.03
Match: 1m1jC
Description: Fibrinogen C-terminal domains; Fibrinogen gamma chain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [454-611]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DISEARQTLQ QVSSTAQDNA DKLTEFERVQ LEIIEKNKTI KTLNQRLIDL KKTVQKELRS  60
   61 AQISTDSESH PTTTPGHRIS SSSLEAFSTG DKGNCVIMDE VNFQYLKHVI VKFLTSREVE 120
  121 ARHLVRAVST LLQLTTEEEK LLHDTLNWKM SWFGMKPT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.30103
Match: 2iw5A
Description: No description for 2iw5A was found.

Predicted functions:

Term Confidence Notes
binding 2.45058468282438 bayes_pls_golite062009
cytoskeletal protein binding 2.1457670954804 bayes_pls_golite062009
chromatin binding 1.87338136043944 bayes_pls_golite062009
actin binding 1.48871115327078 bayes_pls_golite062009
transcription regulator activity 1.38505016881116 bayes_pls_golite062009
DNA binding 1.29464499177454 bayes_pls_golite062009
nucleic acid binding 1.27419374347122 bayes_pls_golite062009
protein binding 1.03780839342631 bayes_pls_golite062009
transcription factor activity 0.694399096428821 bayes_pls_golite062009
histone binding 0.508815747007202 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.45737598186064 bayes_pls_golite062009
sequence-specific DNA binding 0.41388714312156 bayes_pls_golite062009
actin filament binding 0.26311995282891 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle