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View Structure Prediction Details

Protein: FBpp0301623
Organism: Drosophila melanogaster
Length: 1320 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0301623.

Description E-value Query
Range		 Subject
Range
gi|109488222 - gi|109488222|ref|XP_001077587.1| PREDICTED: similar to Myosin heavy chain, skeletal muscle, adult 2 ...
 557.0 [0..25] [1318..794]

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Predicted Domain #1
Region A:
Residues: [1-375] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSNRTSSSH NSRNLKILNA SFDVPRPPGG GNSPLPSQGR SVRELEEQMS ALRKENFNLK  60
   61 LRIYFLEEGQ PGARADSSTE SLSKQLIDAK IEIATLRKTV DVKMELLKDA ARAISHHEEL 120
  121 QRKADIDSQA IIDELQEQIH AYQMAESGGQ PVENIAKTRK MLRLESEVQR LEEELVNIEA 180
  181 RNVAARNELE FMLAERLESL TACEGKIQEL AIKNSELVER LEKETASAES SNEAIDSLKV 240
  241 ELEACRKENQ DLVTSIRTLK HDMKRQVRSM KEAANTMDVQ RQSILLLEAT IKRKEKSCGS 300
  301 MQKNVLNYEA LIAKLNAELE TMRQQNVYFR ELSENLQQKE VRQLDRGVAI VQPMRMTADA 360
  361 GRFVWQSGTI VAQEP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [376-494] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPLERQSAAA TSNVSVSAVR LSSGPPPDQT YPVNGHDRAK YGLLQLFAAK LDWISAVPLA  60
   61 LGHLALKIIL LAMRLHSCLQ NVHIPLRANR DLGAQLADKI CELQEAQEKL KERERIHEQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.154902
Match: 2tmaA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [495-833] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ACRTIQKLMQ KLSSQEKEIK KLNQENEQSA NKENDCAKTV ISPSSSGRSM SDNEASSQEM  60
   61 STNLRVRYEL KINEQEEKIK QLQTEVKKKT ANLQNLVNKE LWEKNREVER LTKLLANQQK 120
  121 TLPQISEESA GEADLQQSFT EAEYMRALER NKLLQRKVDV LFQRLADDQQ NSAVIGQLRL 180
  181 ELQQARTEVE TADKWRLECV DVCSVLTNRL EELAGFLNSL LKHKDVLGVL AADRRNAMRK 240
  241 AVDRSLDLSK SLNMTLNITA TSLADQSLAQ LCNLSEILYT EGDASHKTFN SHEELHAATS 300
  301 MAPTVENLKA ENKALKKELE KRRSSEGQRK ERRSLPLPS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.43
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [834-1021] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQFDNQSESE AWSEPDRKVS LARIGLDETS NSLAAPEQAI SESESEGRTC ATRQDRNRNS  60
   61 ERIAQLEEQI AQKDERMLNV QCQMVELDNR YKQEQLRCLD ITQQLEQLRA INEALTADLH 120
  121 AIGSHEEERM VELQRQLELK NQQIDQLKLA HSTLTADSQI TEMELQALQQ QMQEIEQLHA 180
  181 DSVETLQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.39794
Match: 2iw5A
Description: No description for 2iw5A was found.

Predicted functions:

Term Confidence Notes
actin binding 2.52775592528812 bayes_pls_golite062009
binding 2.45058468282438 bayes_pls_golite062009
cytoskeletal protein binding 2.1457670954804 bayes_pls_golite062009
transcription regulator activity 2.09157817179555 bayes_pls_golite062009
DNA binding 2.02150889787803 bayes_pls_golite062009
transcription factor activity 1.63173451778586 bayes_pls_golite062009
nucleic acid binding 1.27419374347122 bayes_pls_golite062009
actin filament binding 1.22830639594779 bayes_pls_golite062009
sequence-specific DNA binding 1.19342126720259 bayes_pls_golite062009
protein binding 0.853351196918381 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.82709508945531 bayes_pls_golite062009
transcription activator activity 0.18183175007284 bayes_pls_golite062009
transcription repressor activity 0.16239538021276 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1022-1224] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLQKLKLDAV QQLEEHERLH REALERDWVA LTTYQEQAQQ LLELQRSLDY HQENEKELKQ  60
   61 TLVENELATR ALKKQLDEST LQASKAVMER TKAYNDKLQL EKRSEELRLQ LEALKEEHQK 120
  121 LLQKRSNSSD VSQSGYTSEE VAVPMGPPSG QATTCKQAAA AVLGQRVNTS SPDLGIESDA 180
  181 GRISSVEVSN AQRAMLKTVE MKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 2dfsA
Description: No description for 2dfsA was found.

Predicted Domain #6
Region A:
Residues: [1225-1320] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGSASPKAKS EESTSPDSKS NVATGAATVH DCAKVDLENA ELRRKLIRTK RAFEDTYEKL  60
   61 RMANKAKAQV EKDIKNQILK THNVLRNVRS NMENEL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle