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View Structure Prediction Details

Protein: trpl-PD, trpl-PB...
Organism: Drosophila melanogaster
Length: 1124 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trpl-PD, trpl-PB....

Description E-value Query
Range
Subject
Range
gi|84907, gi|158715 - pir||JH0588 calmodulin-binding protein trpl - fruit fly (Drosophila melanogaster), gi|158715|gb|AAA...
654.0 [0..48] [1124..48]

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Predicted Domain #1
Region A:
Residues: [1-361]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRKKKLPTG VSSGVSHASS APKSVGGCCV PLGLPQPLLL EEKKFLLAVE RGDMPNVRRI  60
   61 LQKALRHQHI NINCMDPLGR RALTLAIDNE NLEMVELLVV MGVETKDALL HAINAEFVEA 120
  121 VELLLEHEEL IYKEGEPYSW QKVDINTAMF APDITPLMLA AHKNNFEILR ILLDRGAAVP 180
  181 VPHDIRCGCE ECVRLTAEDS LRHSLSRVNI YRALCSPSLI CLTSNDPIIT AFQLSWELRN 240
  241 LALTEQECKS EYMDLRRQCQ KFAVDLLDQT RTSNELAIIL NYDPQMSSYE PGDRMSLTRL 300
  301 VQAISYKQKK FVAHSNIQQL LSSIWYDGLP GFRRKSIVDK VICIAQVAVL FPLYCLIYMC 360
  361 A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.69897
Match: 1n11A
Description: Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
metal ion transmembrane transporter activity 3.06689459321273 bayes_pls_golite062009
ion transmembrane transporter activity 2.89029061890648 bayes_pls_golite062009
cation transmembrane transporter activity 2.66479899929908 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.59441577402651 bayes_pls_golite062009
calcium channel activity 2.42383730626707 bayes_pls_golite062009
passive transmembrane transporter activity 2.39688396372487 bayes_pls_golite062009
channel activity 2.39688396372487 bayes_pls_golite062009
cation channel activity 2.37772481426745 bayes_pls_golite062009
ion channel activity 2.36752848265558 bayes_pls_golite062009
substrate-specific channel activity 2.26531840012081 bayes_pls_golite062009
binding 1.96927469603571 bayes_pls_golite062009
gated channel activity 1.75472864911207 bayes_pls_golite062009
molecular transducer activity 1.68903441797843 bayes_pls_golite062009
signal transducer activity 1.68903441797843 bayes_pls_golite062009
structural constituent of muscle 1.64895183402675 bayes_pls_golite062009
protein binding 1.64872738860757 bayes_pls_golite062009
transporter activity 1.19000052859754 bayes_pls_golite062009
transmembrane transporter activity 1.02570255606772 bayes_pls_golite062009
receptor activity 0.976205440274192 bayes_pls_golite062009
substrate-specific transporter activity 0.835937200249181 bayes_pls_golite062009
transmembrane receptor activity 0.797192905752426 bayes_pls_golite062009
mechanically gated channel activity 0.645199153849127 bayes_pls_golite062009
mechanically-gated ion channel activity 0.645199153849127 bayes_pls_golite062009
cytoskeletal protein binding 0.45950244714772 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [362-766]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNCRTGQLMR KPFMKFLIHA SSYLFFLFIL ILVSQRADDD FVRIFGTTRM KKELAEQELR  60
   61 QRGQTPSKLE LIVVMYVIGF VWEEVQEIFA VGMKSYLRNM WNFIDFLRNS LYVSVMCLRA 120
  121 FAYIQQATEI ARDPQMAYIP REKWHDFDPQ LIAEGLFAAA NVFSALKLVH LFSINPHLGP 180
  181 LQISLGRMVI DIVKFFFIYT LVLFAFACGL NQLLWYFAAL EKSKCYVLPG GEADWGSHGD 240
  241 SCMKWRRFGN LFESSQSLFW ASFGMVGLDD FELSGIKSYT RFWGLLMFGS YSVINVIVLL 300
  301 NLLIAMMSNS YAMIDEHSDT EWKFARTKLW MSYFEDSATL PPPFNVLPSV KWVIRIFRKS 360
  361 SKTIDRQRSK KRKEQEQFSE YDNIMRSLVW RYVAAMHRKF ENNPV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.154902
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [767-990]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEDDINEVKS EINTMRYEML EIFENSGMDV SSANKKERQP RPRRIKVWER RLMKGFQVAP  60
   61 VQNGCELDAF GNVNGQGEMQ EIKVESIPSK PAKETAKERF QRVARTVLLQ STTHKWNVVL 120
  121 RAAKDSQIGR CTKNERKSLQ NLGRAIEEAK RLIMLNPGCP SGRESPIRIE FEDEKTSTLL 180
  181 ELLNQISAEI SDSEKPKIRP IWRPPLKTVP ARAMAANNTR SLTA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [991-1124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PELKISRKSS PAPTPTPTPG VSHTALSQFR NRELPLCPSK LIANSAPSAP TAPPKKSAPT  60
   61 APTPTYKPTT HAPFSVEGGN RENTRASDGV RSDNSNFDIH VVDLDEKGGH LGRDNVSDIS 120
  121 SIASTSPQRP KHRN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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