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View Structure Prediction Details

Protein: Su(var)2-10-PH
Organism: Drosophila melanogaster
Length: 569 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Su(var)2-10-PH.

Description E-value Query
Range		 Subject
Range
gi|220950582 - gi|220950582|gb|ACL87834.1| Su(var)2-10-PA [synthetic construct]
Su(var)2-10-PD - The gene Suppressor of variegation 2-10 is referred to in FlyBase by the symbol Dmel\Su(var)2-10 (CG...
 566.0 [0..1] [563..1]

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Predicted Domain #1
Region A:
Residues: [1-99] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKTRSQTAR TQAENAATSS SPGHQSTSSA PIAVNPFDST KYKECEQMVQ MLRVVELQKI  60
   61 LSFLNISFAG RKTDLQSRIL SFLRTNLELL APKVQEVYA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1v66A
Description: Solution structure of human p53 binding domain of PIAS-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
SUMO ligase activity 7.09211721404578 bayes_pls_golite062009
small conjugating protein ligase activity 5.19208367271658 bayes_pls_golite062009
acid-amino acid ligase activity 4.23914967265256 bayes_pls_golite062009
transcription regulator activity 3.41663142583782 bayes_pls_golite062009
DNA binding 3.10342439340038 bayes_pls_golite062009
nucleic acid binding 3.06883460395012 bayes_pls_golite062009
binding 2.85946414867169 bayes_pls_golite062009
transcription repressor activity 2.74753557795928 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.29668422758615 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.24838171947021 bayes_pls_golite062009
transcription corepressor activity 2.19580341360526 bayes_pls_golite062009
transcription coactivator activity 2.00568376574074 bayes_pls_golite062009
transcription factor binding 1.87393007510949 bayes_pls_golite062009
transcription cofactor activity 1.74991817705903 bayes_pls_golite062009
steroid hormone receptor binding 1.6614513749396 bayes_pls_golite062009
hormone receptor binding 1.54663504907102 bayes_pls_golite062009
protein binding 1.4634286530239 bayes_pls_golite062009
androgen receptor binding 1.42204964058772 bayes_pls_golite062009
transcription activator activity 1.33699031660219 bayes_pls_golite062009
nuclear hormone receptor binding 1.31532203831033 bayes_pls_golite062009
chromatin binding 0.65047159761755 bayes_pls_golite062009
receptor binding 0.52768617849698 bayes_pls_golite062009
catalytic activity 0.454272578060498 bayes_pls_golite062009
ligase activity 0.36302660895622 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [100-209] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSVQEQNATL QYIDPTRMYS HIQLPPTVQP NPVGLVGSGQ GVQVPGGQMN VVGGAPFLHT  60
   61 HSINSQLPIH PDVRLKKLAF YDVLGTLIKP STLVPRNTQR VQEVPFYFTL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [210-353] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPQQATEIAS NRDIRNSSKV EHAIQVQLRF CLVETSCDQE DCFPPNVNVK VNNKLCQLPN  60
   61 VIPTNRPNVE PKRPPRPVNV TSNVKLSPTV TNTITVQWCP DYTRSYCLAV YLVKKLTSTQ 120
  121 LLQRMKTKGV KPADYTRGLI KEKL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [354-437] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEDADCEIAT TMLKVSLNCP LGKMKMLLPC RASTCSHLQC FDASLYLQMN ERKPTWNCPV  60
   61 CDKPAIYDNL VIDGYFQEVL GSSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 2yu4A
Description: No description for 2yu4A was found.

Predicted Domain #5
Region A:
Residues: [438-569] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKSDDTEIQL HQDGSWSTPG LRSETQILDT PSKPAQKVEV ISDDIELISD DAKPVKRDLS  60
   61 PAQDEQPTST SNSETVDLTL SDSDDDMPLA KRRPPAKQAV ASSTSNGSGG GQRAYTPAQQ 120
  121 PQQSGTLDPF LQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle