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View Structure Prediction Details

Protein: Optix-PA
Organism: Drosophila melanogaster
Length: 487 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Optix-PA.

Description E-value Query
Range
Subject
Range
gi|47230134 - gi|47230134|emb|CAG10548.1| unnamed protein product [Tetraodon nigroviridis]
222.0 [0..29] [223..1]

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Predicted Domain #1
Region A:
Residues: [1-129]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVGPTEGKQ PPSESFSPTH HQIIAPSPIL AVPTLAFSAA QVEIVCKTLE DSGDIERLAR  60
   61 FLWSLPVALP NMHEILNCEA VLRARAVVAY HVGNFRELYA IIENHKFTKA SYGKLQAMWL 120
  121 EAHYIEAEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.154902
Match: 1rutX
Description: Complex of LMO4 LIM domains 1 and 2 with the ldb1 LID domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.16757861573985 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 1.62841402245495 bayes_pls_golite062009
transcription activator activity 1.62405765585032 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.50210964370113 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
protein binding 1.39455913713025 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.68270103300828 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
transcription repressor activity 0.256420113528322 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [130-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRGRSLGPVD KYRVRKKFPL PPTIWDGEQK THCFKERTRS LLREWYLQDP YPNPTKKREL  60
   61 AKATGLNPTQ VGNWFKNRRQ RDRAAAAKNR IQHSQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.30103
Match: 1fjlA
Description: Paired protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [225-387]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSGMGCRSR RADGAASPTP SDSSDSDISL GTHSPVPSSL QLQHSPGSTS NGANDREESL  60
   61 SVDDDKPRDL SGSLPLPLSL PLPLASPTHT PPQLPPGYGG GAGAGPGGPL TGPGCLPPFK 120
  121 LDAATSLFSA GCYLQSFSNL KEMSQQFPIQ PIVLRPHPQL PQS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [388-487]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LALNGASGGP PLHHPAYAAA YSVECVPGGH GPPHPPPKLR INSPEKLNST AVAAAASVGG  60
   61 GGGNQHHEPT TTGYHHSGQL MLHRPFSTSP ELKHSAPEIT 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle