YRC Public Data Repository - Protein Structure Prediction

Protein:	Prosalpha1-PA, C...
Organism:	Drosophila melanogaster
Length:	244 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Prosalpha1-PA, C....

Description	E-value	Query Range	Subject Range
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1 PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1	273.0	[0..2]	[237..3]
PSA_THEK1 - Proteasome subunit alpha OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=psmA PE=3 SV=1 PSA_THEK1, PSMA_... - Proteasome subunit alpha OS=Thermococcus sp. (strain KS-1) GN=psmA PE=3 SV=1, Proteasome subunit alp... gi\|11265988 - pir\|\|T43887 proteasome alpha chain [imported] - Thermococcus sp	273.0	[0..2]	[240..3]
PSMA_PYRKO - Proteasome subunit alpha OS=Pyrococcus kodakaraensis GN=psmA PE=3 SV=1 PSA_THEKO - Proteasome subunit alpha OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=ps...	272.0	[0..2]	[240..3]
PSA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=p... PSMA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus GN=psmA PE=3 SV=1	272.0	[0..2]	[237..3]
gi\|73962756, gi\|... - gi\|73962764\|ref\|XP_862262.1\| PREDICTED: similar to Proteasome subunit alpha type 6 (Proteasome iota ...	271.0	[0..1]	[244..1]
gi\|286250 - gi\|286250\|dbj\|BAA01587.1\| proteasome subunit R-IOTA [Rattus sp.] gi\|67969980 - gi\|67969980\|dbj\|BAE01337.1\| unnamed protein product [Macaca fascicularis] PSMA6 - proteasome (prosome, macropain) subunit, alpha type, 6 PSA6_BOVIN - Proteasome subunit alpha type-6 OS=Bos taurus GN=PSMA6 PE=1 SV=1 gi\|55640605, gi\|... - gi\|55640605\|ref\|XP_509906.1\| PREDICTED: proteasome alpha 6 subunit isoform 6 [Pan troglodytes], gi\|1... gi\|109083327, gi... - gi\|109083327\|ref\|XP_001086524.1\| PREDICTED: similar to Proteasome subunit alpha type 6 (Proteasome i... gi\|149692835 - gi\|149692835\|ref\|XP_001491320.1\| PREDICTED: similar to proteasome alpha 6 subunit [Equus caballus] ENSOCUP000000134... - pep:novel chromosome:oryCun2:17:55028440:55047757:1 gene:ENSOCUG00000015635 transcript:ENSOCUT000000... PSA6_RAT - Proteasome subunit alpha type-6 OS=Rattus norvegicus GN=Psma6 PE=1 SV=1 gi\|123983062 - gi\|123983062\|gb\|ABM83272.1\| proteasome (prosome, macropain) subunit, alpha type, 6 [synthetic constr... gi\|222154129 - gi\|222154129\|gb\|ACM47241.1\| proteasome subunit alpha type 6 [Capra hircus] tr\|M3WV20\|M3WV20... - Proteasome subunit alpha type OS=Felis catus GN=PSMA6 PE=3 SV=1	271.0	[0..1]	[244..1]
gi\|50540244, gi\|... - gi\|50540244\|ref\|NP_001002589.1\| zgc:92716 [Danio rerio], gi\|49902952\|gb\|AAH76196.1\| Zgc:92716 [Danio...	271.0	[0..1]	[244..1]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ... PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1	271.0	[0..2]	[237..3]
gi\|109084670, gi... - gi\|109084670\|ref\|XP_001095483.1\| PREDICTED: similar to Proteasome subunit alpha type 6 (Proteasome i...	270.0	[0..1]	[244..1]
gi\|194113736, gi... - gi\|195154060\|ref\|XP_002017940.1\| GL17442 [Drosophila persimilis], gi\|194113736\|gb\|EDW35779.1\| GL1744... gi\|54636173, gi\|... - gi\|54636173\|gb\|EAL25576.1\| GA15805 [Drosophila pseudoobscura pseudoobscura], gi\|125809137\|ref\|XP_001... gi\|125809137\|ref... - GA15805-PA [Drosophila pseudoobscura], GA15805 [Drosophila pseudoobscura pseudoobscura]	270.0	[0..1]	[244..1]

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Predicted Domain #1

Region A:
Residues: [1-244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AIAQENITTV ALKSGDCAVV ATQKKVTEKN  60
   61 IVPETVTHLF RITKDIGCAM TGRIADSRSQ VQKARYEAAN FRYKYGYEMP VDVLCRRIAD 120
  121 INQVYTQNAE MRPLGCSMVL IAYDNEIGPS VYKTDPAGYF SGFKACSVGA KTLEANSYLE 180
  181 KKYKPNLSEE KAIQLAISCL SSVLAIDFKP NGIEIGVVSK SDPTFRILDE REIEEHLTKI 240
  241 AEKD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.0
Match:	1iruA
Description:	Proteasome alpha subunit (non-catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
binding	1.75265921676176	bayes_pls_golite062009
nucleic acid binding	1.39216781236247	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: