YRC Public Data Repository - Protein Structure Prediction

Protein:	EDF1_RAT
Organism:	Rattus norvegicus
Length:	148 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EDF1_RAT.

Description	E-value	Query Range	Subject Range
gi\|73967496 - gi\|73967496\|ref\|XP_537793.2\| PREDICTED: similar to endothelial differentiation-related factor 1 isof...	136.0	[0..1]	[148..43]
gi\|109109703 - gi\|109109703\|ref\|XP_001092659.1\| PREDICTED: similar to endothelial differentiation-related factor 1 ...	133.0	[0..1]	[129..1]
gi\|109469565, gi... - gi\|62644742\|ref\|XP_215993.2\| PREDICTED: similar to Endothelial differentiation-related factor 1 (EDF...	132.0	[0..1]	[148..44]
gi\|60832184 - gi\|60832184\|gb\|AAX37000.1\| endothelial differentiation-related factor 1 [synthetic construct]	131.0	[0..1]	[148..1]
EDF1 - endothelial differentiation-related factor 1 ENSCJAT00000021760 - null EDF1_BOVIN - Endothelial differentiation-related factor 1 OS=Bos taurus GN=EDF1 PE=2 SV=1 gi\|109109699 - gi\|109109699\|ref\|XP_001092893.1\| PREDICTED: similar to endothelial differentiation-related factor 1 ... gi\|61360060, gi\|... - gi\|61360069\|gb\|AAX41806.1\| endothelial differentiation-related factor 1 [synthetic construct], gi\|61...	131.0	[0..1]	[148..1]
EDF1_CHICK - Endothelial differentiation-related factor 1 homolog OS=Gallus gallus GN=EDF1 PE=2 SV=1	131.0	[0..1]	[148..1]
gi\|13094059 - gi\|13094059\|emb\|CAC32040.1\| EDF-1 protein [Mus musculus]	131.0	[0..1]	[148..1]
gi\|77748216, gi\|... - gi\|77748216\|gb\|AAI06502.1\| MGC131240 protein [Xenopus laevis], gi\|148232343\|ref\|NP_001089760.1\| hypo...	129.0	[0..1]	[148..1]
gi\|47218676 - gi\|47218676\|emb\|CAG12400.1\| unnamed protein product [Tetraodon nigroviridis]	126.0	[0..1]	[148..1]

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Predicted Domain #1

Region A:
Residues: [1-64]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAESDWDTVT VLRKKGPTAA QAKSKQAILA AQRRGEDVET SKKWAAGQNK QHSITKNTAK  60
   61 LDRE

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	33.221849
Match:	PF08523.1
Description:	No description for PF08523.1 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.254	0.209	regulation of transcription, DNA-dependent	a.35.1	lambda repressor-like DNA-binding domains
View	Download	0.201	0.029	regulation of transcription, DNA-dependent	d.88.1	SRF-like
View	Download	0.242	0.012	regulation of transcription, DNA-dependent	d.68.7	R3H domain

Predicted Domain #2

Region A:
Residues: [65-148]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEELHHDRVT LEVGKVIQRG RQSKGLTQKD LATKINEKPQ VIADYESGRA IPNNQVLGKI  60
   61 ERAIGLKLRG KDIGKPIEKG PKAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.30103
Match:	1x57A
Description:	Solution structures of the HTH domain of human EDF-1 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA binding	5.51228466689923	bayes_pls_golite062009
nucleic acid binding	5.37468811865033	bayes_pls_golite062009
transcription regulator activity	5.05236457497789	bayes_pls_golite062009
transcription factor activity	3.89464979825638	bayes_pls_golite062009
binding	3.66501723413351	bayes_pls_golite062009
sequence-specific DNA binding	3.25218945600666	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22754992035091	bayes_pls_golite062009
transcription activator activity	3.15886611325686	bayes_pls_golite062009
transcription repressor activity	1.75958281319075	bayes_pls_golite062009
protein binding	1.55649304400241	bayes_pls_golite062009
chromatin binding	1.2739759748489	bayes_pls_golite062009
transcription factor binding	1.02788976342343	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.92393807212912	bayes_pls_golite062009
transcription cofactor activity	0.8718993114781	bayes_pls_golite062009
transcription coactivator activity	0.81316180547536	bayes_pls_golite062009
hydrolase activity	0.705005414525139	bayes_pls_golite062009
promoter binding	0.22765608166458	bayes_pls_golite062009
catalytic activity	0.00446472034106909	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: