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View Structure Prediction Details

Protein: gi|117645444, gi...
Organism: synthetic construct
Length: 472 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|117645444, gi....

Description E-value Query
Range
Subject
Range
gi|109083400 - gi|109083400|ref|XP_001086449.1| PREDICTED: similar to forkhead box A1 [Macaca mulatta]
2.0E-72 [10..472] [201..661]
gi|60654413 - gi|60654413|gb|AAX29897.1| forkhead box A1 [synthetic construct]
1.0E-66 [1..472] [1..472]
FOXA1 - forkhead box A1
3.0E-65 [1..472] [1..473]
gi|61870516 - gi|61870516|ref|XP_613201.1| PREDICTED: forkhead box A1 [Bos taurus]
2.0E-63 [1..472] [1..468]
FOXA1_MOUSE - Hepatocyte nuclear factor 3-alpha OS=Mus musculus GN=Foxa1 PE=1 SV=2
1.0E-62 [1..472] [1..468]
gi|114652732 - gi|114652732|ref|XP_001144389.1| PREDICTED: forkhead box A1 [Pan troglodytes]
1.0E-62 [1..472] [1..477]
FOXA1_RAT - Hepatocyte nuclear factor 3-alpha OS=Rattus norvegicus GN=Foxa1 PE=1 SV=1
3.0E-58 [1..472] [1..466]
gi|73963239 - gi|73963239|ref|XP_852354.1| PREDICTED: similar to forkhead box A1 [Canis familiaris]
3.0E-57 [1..457] [1..465]

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Predicted Domain #1
Region A:
Residues: [1-151]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGTVKMEGH ETSDWNSYYA DTQEAYSSVP VSNMNSGLGS MNSMNTYMTM NTMTTSGNMT  60
   61 PASFNMSYAN PGLGAGLSPG AVAGMPGGSA GAMNSMTAAG VTAMGTALSP SGMGAMGAQQ 120
  121 AASMNGLGPY AAAMNPCMSP MAYAPSNLGR S

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.05
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [152-274]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAGGGGDAKT FKRSYPHAKP PYSYISLITM AIQQAPSKML TLSEIYQWIM DLFPYYRQNQ  60
   61 QRWQNSIRHS LSFNDCFVKV ARSPDKPGKG SYWTLHPDSG NMFENGCYLR RQKRFKCEKQ 120
  121 PGA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.39794
Match: 1d5vA
Description: Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.55329976718261 bayes_pls_golite062009
DNA binding 5.08959163553491 bayes_pls_golite062009
nucleic acid binding 4.99681957904233 bayes_pls_golite062009
transcription factor activity 4.33152142980289 bayes_pls_golite062009
transcription repressor activity 3.85678231380989 bayes_pls_golite062009
transcription activator activity 3.70589483230587 bayes_pls_golite062009
sequence-specific DNA binding 3.58179858678904 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.60738445921725 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.2723726467408 bayes_pls_golite062009
specific transcriptional repressor activity 0.96257232341735 bayes_pls_golite062009
transcription factor binding 0.85714789329232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.66743181561551 bayes_pls_golite062009
transcription corepressor activity 0.322180400748724 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.23177057841536 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [275-382]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGGGSGSGG SGAKGGPESR KDPSGASNPS ADSPLHRGVH GKTGQLEGAP APGPAASPQT  60
   61 LDHSGATATG GASELKTPAS STAPPISSGP GALASVPASH PAHGLAPH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.05
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [383-472]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESQLHLKGDP HYSFNHPFSI NNLMSSSEQQ HKLDFKAYEQ ALQYSPYGST LPASLPLGSA  60
   61 SVTTRSPIEP SALEPAYYQG VYSRPVLNTS 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle