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View Structure Prediction Details

Protein: gi|114616493
Organism: Pan troglodytes
Length: 452 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|114616493.

Description E-value Query
Range
Subject
Range
gi|37589083 - gi|37589083|gb|AAH02427.2| Caspase 2, apoptosis-related cysteine peptidase [Homo sapiens]
0.0 [1..452] [1..452]
gi|26334905 - gi|26334905|dbj|BAC31153.1| unnamed protein product [Mus musculus]
0.0 [1..452] [1..452]
CASP2_RAT - Caspase-2 OS=Rattus norvegicus GN=Casp2 PE=1 SV=3
0.0 [1..452] [1..452]
gi|61372145, gi|... - gi|61372152|gb|AAX43792.1| caspase 2 [synthetic construct], gi|61372145|gb|AAX43791.1| caspase 2 [sy...
0.0 [18..452] [1..435]
gi|114616491 - gi|114616491|ref|XP_001162422.1| PREDICTED: caspase 2 isoform 3 [Pan troglodytes]
0.0 [23..452] [10..439]
gi|73978459 - gi|73978459|ref|XP_848601.1| PREDICTED: similar to caspase 2 isoform 1 preproprotein isoform 2 [Cani...
0.0 [12..452] [12..452]

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Predicted Domain #1
Region A:
Residues: [1-177]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ LLLSELLEHL  60
   61 LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD AFCEALRETK QGHLEDMLLT 120
  121 TLSGLQHVLP PLSCDYDLSL PFPVCESCPL YKKLRLSTDT VEHSLDNKDG PVCLQVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.39794
Match: 1z6tA
Description: Structure of the apoptotic protease-activating factor 1 bound to ADP
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [178-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PCTPEFYQTH FQLAYRLQSR PRGLALVLSN VHFTGEKELE FRSGGDVDHS TLVTLFKLLG  60
   61 YDVHVLCDQT AQEMQEKLQN FAQLPAHRVT DSCIVALLSH GVEGAIYGVD GKLLQLQEVF 120
  121 QLFDNANCPS LQNKPKMFFI QACRGDETDR GVDQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.30103
Match: 1pyoA
Description: Crystal Structure of Human Caspase-2 in Complex with Acetyl-Leu-Asp-Glu-Ser-Asp-cho
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.24815349282067 bayes_pls_golite062009
protein binding 2.96725373477762 bayes_pls_golite062009
binding 2.91261616137775 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 2.60103365510479 bayes_pls_golite062009
hydrolase activity 2.45602706385958 bayes_pls_golite062009
cysteine-type peptidase activity 2.37850336421322 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.07426831021634 bayes_pls_golite062009
apoptotic protease activator activity 2.001549901512 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.82979469421101 bayes_pls_golite062009
endopeptidase activity 1.58137850574981 bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity 1.38256499817012 bayes_pls_golite062009
catalytic activity 1.03907950272772 bayes_pls_golite062009
enzyme regulator activity 0.0737251792690711 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [332-452]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDGKNHAGSP GCEESDAGKE KLPKMRLPTR SDMICGYACL KGTAAMRNTK RGSWYIEALA  60
   61 QVFSERACDM HVADMLVKVN ALIKDREGYA PGTEFHRCKE MSEYCSTLCR HLYLFPGHPP 120
  121 T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.522879
Match: 1pyoB
Description: Crystal Structure of Human Caspase-2 in Complex with Acetyl-Leu-Asp-Glu-Ser-Asp-cho
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle