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View Structure Prediction Details

Protein: CYTS_RAT
Organism: Rattus norvegicus
Length: 141 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYTS_RAT.

Description E-value Query
Range
Subject
Range
gi|539565, gi|398711 - pir||A47142 cystatin D precursor - human, gi|398711|emb|CAA49838.1| cystatin D [Homo sapiens]
165.0 [0..1] [141..1]
gi|192912, gi|109759 - gi|192912|gb|AAA63298.1| cystatin C, pir||A36163 cystatin C precursor - mouse
164.0 [0..1] [140..1]
gi|109093125 - gi|109093125|ref|XP_001097284.1| PREDICTED: cystatin SA [Macaca mulatta]
160.0 [0..1] [140..1]
gi|58081 - gi|58081|emb|CAA31253.1| ompA - cystatin C fusion preprotein (AA -21 to 120) [synthetic construct]
159.0 [0..1] [140..1]
gi|55651412 - gi|55651412|ref|XP_514555.1| PREDICTED: similar to Cystatin SA precursor (Cystatin S5) isoform 3 [Pa...
158.0 [0..1] [140..1]

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Predicted Domain #1
Region A:
Residues: [1-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYLLHAQLF LLTTFILVLN MRLCPVLGHF LGGIEKSSME EEGASEALNY AVNEYNEKNS  60
   61 DLYLSRVVEV KDVQKQVVAG TKFFFDVILG KTICLKTQGD LTNCPLNEEA DQQEHEFCSF 120
  121 VVHDIPWENY IVLLSSSCHS I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.69897
Match: 1g96A
Description: Cystatin C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cysteine-type endopeptidase inhibitor activity 5.18960601077151 bayes_pls_golite062009
protease binding 3.73826839062329 bayes_pls_golite062009
enzyme inhibitor activity 3.46240889348325 bayes_pls_golite062009
endopeptidase inhibitor activity 2.16387275532719 bayes_pls_golite062009
peptidase inhibitor activity 2.10667869451861 bayes_pls_golite062009
enzyme binding 1.6342022584305 bayes_pls_golite062009
binding 1.55087889773804 bayes_pls_golite062009
protein binding 0.823288035712675 bayes_pls_golite062009
enzyme regulator activity 0.479748849334581 bayes_pls_golite062009
beta-amyloid binding 0.0968491675668099 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle