YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|117645424, gi...
Organism:	synthetic construct
Length:	145 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|117645424, gi....

Description	E-value	Query Range	Subject Range
gi\|117646878 - gi\|117646878\|emb\|CAL37554.1\| hypothetical protein [synthetic construct] gi\|17390048 - gi\|17390048\|gb\|AAH18029.1\| 6-pyruvoyltetrahydropterin synthase [Homo sapiens]	8.0E-49	[1..145]	[1..145]
gi\|109108666 - gi\|109108666\|ref\|XP_001108264.1\| PREDICTED: 6-pyruvoyltetrahydropterin synthase [Macaca mulatta]	1.0E-48	[1..145]	[1..145]
gi\|114640356 - gi\|114640356\|ref\|XP_001147929.1\| PREDICTED: 6-pyruvoyltetrahydropterin synthase [Pan troglodytes]	1.0E-48	[1..145]	[1..145]
PTPS_PONAB - 6-pyruvoyl tetrahydrobiopterin synthase OS=Pongo abelii GN=PTS PE=2 SV=1 PTPS_PONPY - 6-pyruvoyl tetrahydrobiopterin synthase - Pongo pygmaeus (Orangutan)	2.0E-48	[1..145]	[1..145]
gi\|78213852, gi\|... - gi\|78213852\|ref\|YP_382631.1\| 6-pyruvoyltetrahydropterin synthase [Synechococcus sp. CC9605], gi\|7819...	4.0E-48	[3..145]	[145..289]
gi\|116071454, gi... - gi\|116071454\|ref\|ZP_01468722.1\| 6-pyruvoyltetrahydropterin synthase [Synechococcus sp. BL107], gi\|11...	3.0E-47	[3..145]	[83..227]
gi\|88788351, gi\|... - gi\|88807137\|ref\|ZP_01122649.1\| 6-pyruvoyltetrahydropterin synthase [Synechococcus sp. WH 7805], gi\|8...	1.0E-46	[3..145]	[145..289]
PTPS_POERE - 6-pyruvoyl tetrahydrobiopterin synthase OS=Poecilia reticulata GN=pts PE=2 SV=1	1.0E-46	[3..145]	[2..147]
gi\|78168222, gi\|... - gi\|78183928\|ref\|YP_376363.1\| 6-pyruvoyltetrahydropterin synthase [Synechococcus sp. CC9902], gi\|7816...	2.0E-46	[3..145]	[145..289]
gi\|17232046, gi\|... - gi\|17232046\|ref\|NP_488594.1\| hypothetical protein alr4554 [Nostoc sp. PCC 7120], gi\|17133690\|dbj\|BAB... gi\|25530206 - pir\|\|AB2375 hypothetical protein alr4554 [imported] - Nostoc sp. (strain PCC 7120)	3.0E-46	[3..143]	[127..269]

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Predicted Domain #1

Region A:
Residues: [1-145]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTEGGGRRC QAQVSRRISF SASHRLYSKF LSDEENLKLF GKCNNPNGHG HNYKVVVTVH  60
   61 GEIDPATGMV MNLADLKKYM EEAIMQPLDH KNLDMDVPYF ADVVSTTENV AVYIWDNLQK 120
  121 VLPVGVLYKV KVYETDNNIV VYKGE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.69897
Match:	1b66A
Description:	6-pyruvoyl tetrahydropterin synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTP cyclohydrolase I activity	4.1430878480831	bayes_pls_golite062009
cyclohydrolase activity	3.66553359909123	bayes_pls_golite062009
GTP cyclohydrolase activity	3.44912994722205	bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity	2.77658228107642	bayes_pls_golite062009
dihydroneopterin aldolase activity	2.51107306055654	bayes_pls_golite062009
catalytic activity	2.20788162511962	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.73101699306211	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.974891318710762	bayes_pls_golite062009
binding	0.759103762434885	bayes_pls_golite062009
protein binding	0.321209012356616	bayes_pls_golite062009
oxidoreductase activity	0.0783540825826956	bayes_pls_golite062009
urate oxidase activity	0.0294957696532921	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: