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View Structure Prediction Details

Protein: RHOX5_MOUSE
Organism: Mus musculus
Length: 210 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RHOX5_MOUSE.

Description E-value Query
Range
Subject
Range
gi|6003605 - gi|6003605|gb|AAF00509.1| homeobox protein [Mastomys sp.]
161.0 [0..1] [210..1]
gi|6003596 - gi|6003596|gb|AAF00507.1| homeobox protein [Mus caroli]
136.0 [0..1] [210..1]
gi|786328 - gi|786328|gb|AAB32671.1| Pax-6 [Rattus sp.]
gi|480038, gi|446399 - gi|480038|pir||S36166 paired box transcription factor Pax-6 - rat (fragment), gi|446399|prf||1911405...
135.0 [0..5] [210..25]
gi|33440489 - gi|33440489|gb|AAH56204.1| Reproductive homeobox 5 [Mus musculus]
133.0 [0..1] [210..1]
gi|6003617 - gi|6003617|gb|AAF00512.1| homeobox protein [Mus saxicola]
132.0 [0..1] [210..1]
gi|6003613 - gi|6003613|gb|AAF00511.1| homeobox protein [Mus pahari]
127.0 [0..1] [210..1]
gi|6003621 - gi|6003621|gb|AAF00513.1| homeobox protein [Stochomys longicaudatus]
126.0 [0..1] [210..1]

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Predicted Domain #1
Region A:
Residues: [1-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAEGSSRKV TRLLRLGVKE DSEEQHDVKA EAFFQAGEGR DEQGAQGQPG VGAVGTEGEG  60
   61 EELNGGKGHF GPGAPGPMGD GDKDSGTRAG GVEQEQNEPV A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [102-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGTESQENGN PGGRQMPLQG SRFAQHRLRE LESILQRTNS FDVPREDLDR LMDACVSRVQ  60
   61 NWFKIRRAAA RRTRRRATPV PEHFRGTFEC PACRGVRWGE RCPFATPRF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.154902
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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