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View Structure Prediction Details

Protein: B2L10_MOUSE
Organism: Mus musculus
Length: 191 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for B2L10_MOUSE.

Description E-value Query
Range
Subject
Range
gi|30851239 - gi|30851239|gb|AAH52690.1| Bcl2l10 protein [Mus musculus]
202.0 [0..1] [191..1]
B2L10_RAT - Bcl-2-like protein 10 OS=Rattus norvegicus GN=Bcl2l10 PE=2 SV=1
196.0 [0..6] [191..3]
gi|50978630, gi|... - gi|50978630|ref|NP_001003011.1| BCL2-associated X protein [Canis lupus familiaris], gi|27372190|dbj|...
183.0 [0..4] [191..15]
MCL1 - myeloid cell leukemia sequence 1 (BCL2-related)
182.0 [0..3] [188..169]
BAX_BOVIN - Apoptosis regulator BAX OS=Bos taurus GN=BAX PE=2 SV=1
181.0 [0..4] [191..15]
gi|114678174 - gi|114678174|ref|XP_001155879.1| PREDICTED: similar to Bax alpha [Pan troglodytes]
181.0 [0..4] [191..86]

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Predicted Domain #1
Region A:
Residues: [1-191]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADSQDPLHE RTRRLLSDYI FFCAREPDTP EPPPTSVEAA LLRSVTRQIQ QEHQEFFSSF  60
   61 CESRGNRLEL VKQMADKLLS KDQDFSWSQL VMLLAFAGTL MNQGPYMAVK QKRDLGNRVI 120
  121 VTRDCCLIVN FLYNLLMGRR HRARLEALGG WDGFCRFFKN PLPLGFWRRL LIQAFLSGFF 180
  181 ATAIFFIWKR L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.09691
Match: 1f16A
Description: Proapoptotic molecule Bax
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
BH3 domain binding 2.69016495057203 bayes_pls_golite062009
binding 2.59561200514645 bayes_pls_golite062009
BH domain binding 2.27237827754342 bayes_pls_golite062009
caspase inhibitor activity 2.08013825948248 bayes_pls_golite062009
protein binding 1.99315623629974 bayes_pls_golite062009
protein dimerization activity 1.73789508200675 bayes_pls_golite062009
death domain binding 1.68707791178093 bayes_pls_golite062009
caspase regulator activity 1.49377208228548 bayes_pls_golite062009
protein heterodimerization activity 1.28226471040487 bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity 1.14864482798901 bayes_pls_golite062009
protease binding 0.775628666218753 bayes_pls_golite062009
identical protein binding 0.464207026816411 bayes_pls_golite062009
transcription regulator activity 0.0304736434950499 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle