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View Structure Prediction Details

Protein: NTF3_MOUSE
Organism: Mus musculus
Length: 258 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NTF3_MOUSE.

Description E-value Query
Range
Subject
Range
gi|109095185 - gi|109095185|ref|XP_001118191.1| PREDICTED: neurotrophin 3 [Macaca mulatta]
409.0 [0..1] [258..71]
NTF3_RAT - Neurotrophin-3 OS=Rattus norvegicus GN=Ntf3 PE=2 SV=1
408.0 [0..1] [258..1]
gi|74209040 - gi|74209040|dbj|BAE21247.1| unnamed protein product [Mus musculus]
408.0 [0..1] [258..14]
gi|51949752 - gi|51949752|gb|AAU14794.1| neurotrophin 3 precursor [synthetic construct]
406.0 [0..1] [258..1]
gi|114642998 - gi|114642998|ref|XP_522331.2| PREDICTED: neurotrophin 3 [Pan troglodytes]
406.0 [0..1] [258..1]
NTF3 - neurotrophin 3
gi|60818243, gi|... - gi|60818243|gb|AAX36456.1| neurotrophin 3 [synthetic construct], gi|208968625|dbj|BAG74151.1| neurot...
403.0 [0..1] [258..1]
gi|73997470 - gi|73997470|ref|XP_543858.2| PREDICTED: similar to Neurotrophin-3 precursor (NT-3) (Neurotrophic fac...
401.0 [0..1] [258..1]
NTF3_FELCA - Neurotrophin-3 OS=Felis catus GN=NTF3 PE=3 SV=1
398.0 [0..1] [258..1]
NTF3_CHICK - Neurotrophin-3 OS=Gallus gallus GN=NTF3 PE=2 SV=2
390.0 [0..1] [258..1]

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Predicted Domain #1
Region A:
Residues: [1-134]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSILFYVIFL AYLRGIQGNS MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ  60
   61 STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 120
  121 EDYVGNPVVA NRTS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.372 N/A N/A a.63.1 Apolipophorin-III
View Download 0.315 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.309 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.277 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.256 N/A N/A a.118.8 TPR-like

Predicted Domain #2
Region A:
Residues: [135-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRRKRYAEHK SHRGEYSVCD SESLWVTDKS SAIDIRGHQV TVLGEIKTGN SPVKQYFYET  60
   61 RCKEARPVKN GCRGIDDKHW NSQCKTSQTY VRALTSENNK LVGWRWIRID TSCVCALSRK 120
  121 IGRT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.0
Match: 1b8kA
Description: Neurotrophin 3, NT3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
growth factor activity 4.74498867224238 bayes_pls_golite062009
receptor binding 4.70889547404918 bayes_pls_golite062009
neurotrophin TRKB receptor binding 4.62719877337644 bayes_pls_golite062009
neurotrophin TRK receptor binding 4.62719877337644 bayes_pls_golite062009
neurotrophin p75 receptor binding 4.09253117188665 bayes_pls_golite062009
cytokine activity 3.61376517935324 bayes_pls_golite062009
receptor serine/threonine kinase binding 3.60727548920187 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 3.46872954776606 bayes_pls_golite062009
transforming growth factor beta receptor binding 3.46872954776606 bayes_pls_golite062009
protein binding 3.41839891062651 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 3.16494996397951 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 3.0813162230094 bayes_pls_golite062009
cell surface binding 2.9725198156666 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 2.85718611591787 bayes_pls_golite062009
binding 2.85157432803513 bayes_pls_golite062009
platelet-derived growth factor receptor binding 2.5098842713893 bayes_pls_golite062009
glycosaminoglycan binding 2.49731836866959 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 2.3694685471074 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 2.18218102861024 bayes_pls_golite062009
growth factor binding 2.15782167869238 bayes_pls_golite062009
heparin binding 2.11784489374422 bayes_pls_golite062009
hormone activity 2.10500409590202 bayes_pls_golite062009
protein dimerization activity 1.82426827198541 bayes_pls_golite062009
transcription regulator activity 1.71788348798334 bayes_pls_golite062009
protein homodimerization activity 1.377005150119 bayes_pls_golite062009
molecular transducer activity 1.3285764158511 bayes_pls_golite062009
signal transducer activity 1.3285764158511 bayes_pls_golite062009
identical protein binding 1.18858126900765 bayes_pls_golite062009
platelet-derived growth factor binding 1.18476084022243 bayes_pls_golite062009
polysaccharide binding 1.16191864095271 bayes_pls_golite062009
transcription activator activity 1.12971001221094 bayes_pls_golite062009
collagen binding 1.00551310632663 bayes_pls_golite062009
protein heterodimerization activity 0.97031505698447 bayes_pls_golite062009
morphogen activity 0.91146826241391 bayes_pls_golite062009
pattern binding 0.90497366619649 bayes_pls_golite062009
nerve growth factor binding 0.83909377726083 bayes_pls_golite062009
protein kinase activity 0.81930974773732 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
vascular endothelial growth factor receptor 3 binding 0.772832351269279 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.461278618625267 bayes_pls_golite062009
kinase activity 0.457160916814967 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.320182329352662 bayes_pls_golite062009
protein serine/threonine kinase activity 0.137002941165399 bayes_pls_golite062009
catalytic activity 0.105223830172599 bayes_pls_golite062009
fibronectin binding 0.0979012997097199 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle