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View Structure Prediction Details

Protein: HXC9_MOUSE
Organism: Mus musculus
Length: 260 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HXC9_MOUSE.

Description E-value Query
Range
Subject
Range
gi|109482992 - gi|109482992|ref|XP_001069410.1| PREDICTED: similar to Homeobox protein Hox-C9 (Hox-3.2) isoform 1 [...
154.0 [0..1] [258..1]
gi|109096999 - gi|109096999|ref|XP_001108363.1| PREDICTED: similar to Homeobox protein Hox-C9 (Hox-3.2) isoform 3 [...
153.0 [0..1] [258..1]
gi|114644440 - gi|114644440|ref|XP_001136284.1| PREDICTED: hypothetical protein isoform 1 [Pan troglodytes]
152.0 [0..1] [258..1]
gi|47228655 - gi|47228655|emb|CAG07387.1| unnamed protein product [Tetraodon nigroviridis]
149.0 [0..1] [259..1]
gi|114644444, gi... - gi|114644444|ref|XP_001136621.1| PREDICTED: homeobox C9 isoform 3 [Pan troglodytes], gi|114644442|re...
gi|208968513 - gi|208968513|dbj|BAG74095.1| homeobox C9 [synthetic construct]
HOXC9 - homeobox C9
137.0 [0..1] [241..1]
gi|113171686 - gi|113171686|gb|ABI30949.1| homeobox C9 [Capra hircus]
136.0 [0..1] [241..1]
gi|66476113 - gi|66476113|gb|AAX63764.2| HoxC9bi [Oncorhynchus mykiss]
135.0 [0..4] [251..1]

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Predicted Domain #1
Region A:
Residues: [1-192]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF PSCSFAPKPA  60
   61 VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL SGAVSFPSFP AGGRHYALKP 120
  121 DAYPGRRADC GPGDGRSYPD YMYGSPGELR DRAPQTLPSP EADALAGSKH KEEKADLDPS 180
  181 NPVANWIHAR ST

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 107.119186
Match: PF04617.4
Description: No description for PF04617.4 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [193-260]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKKRCPYTKY QTLELEKEFL FNMYLTRDRR YEVARVLNLT ERQVKIWFQN RRMKMKKMNK  60
   61 EKTDKEQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.0
Match: 1pufA
Description: Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle