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View Structure Prediction Details

Protein: HXC8_MOUSE
Organism: Mus musculus
Length: 242 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HXC8_MOUSE.

Description E-value Query
Range
Subject
Range
gi|109481376 - gi|109481376|ref|XP_347336.2| PREDICTED: similar to Homeobox protein Hox-C9 (Hox-3.2) [Rattus norveg...
159.0 [0..1] [218..426]
HXB8A_DANRE - Homeobox protein Hox-B8a OS=Danio rerio GN=hoxb8a PE=2 SV=1
152.0 [0..1] [242..1]
HXC8_CHICK - Homeobox protein Hox-C8 OS=Gallus gallus GN=HOXC8 PE=2 SV=1
147.0 [0..1] [218..1]
gi|109114201 - gi|109114201|ref|XP_001088929.1| PREDICTED: similar to homeobox B8 isoform 1 [Macaca mulatta]
HOXB8 - homeobox B8
HGNC:5119|MIM:14... - B8, B8
gi|146327438, gi... - gi|208966500|dbj|BAG73264.1| homeobox B8 [synthetic construct], gi|146327438|gb|AAI41561.1| Homeobox...
ENSCJAT00000014593 - null
147.0 [0..1] [238..1]
gi|57091665 - gi|57091665|ref|XP_548179.1| PREDICTED: similar to homeo box B8 [Canis familiaris]
145.0 [0..1] [238..1]

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Predicted Domain #1
Region A:
Residues: [1-149]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSYFVNPLF SKYKGGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ HASHHVQDFF  60
   61 HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY GAQQEASVVQ YPDCKSSANT 120
  121 NSSEGQGHLN QNSSPSLMFP WMRPHAPGR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [150-242]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSGRQTYSRY QTLELEKEFL FNPYLTRKRR IEVSHALGLT ERQVKIWFQN RRMKWKKENN  60
   61 KDKLPGARDE EKVEEEGNEE EEKEEEEKEE NKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.522879
Match: 1homA
Description: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009

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