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View Structure Prediction Details

Protein: HXA5_MOUSE
Organism: Mus musculus
Length: 270 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HXA5_MOUSE.

Description E-value Query
Range
Subject
Range
gi|15029697 - gi|15029697|gb|AAH11063.1| Homeo box A5 [Mus musculus]
161.0 [0..1] [270..1]
gi|61370212, gi|... - gi|61370212|gb|AAX43455.1| homeobox A5 [synthetic construct], gi|61370206|gb|AAX43454.1| homeobox A5...
159.0 [0..1] [270..1]
gi|72247, gi|387668 - pir||WJHU1C homeotic protein Hox A5 - human, gi|387668|gb|AAA58663.1| HOX 1.3
159.0 [0..1] [270..1]
gi|73976525 - gi|73976525|ref|XP_539487.2| PREDICTED: similar to Homeobox protein Hox-A5 (Hox-1.3) (M2) [Canis fam...
HXA5_BOVIN - Homeobox protein Hox-A5 OS=Bos taurus GN=HOXA5 PE=2 SV=1
gi|170649678 - gi|170649678|gb|ACB21263.1| homeobox A5 (predicted) [Callicebus moloch]
158.0 [0..1] [270..1]
gi|34855875, gi|... - ref|XP_347223.1| similar to homeo domain protein [Rattus norvegicus], ref|XP_342686.1| homeo box A5...
157.0 [0..1] [270..112]
gi|109067082 - gi|109067082|ref|XP_001092687.1| PREDICTED: similar to Homeobox protein Hox-A5 (Hox-1.3) (M2) isofor...
gi|114612539 - gi|114612539|ref|XP_519011.2| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes]
gi|160904219 - gi|160904219|gb|ABX52203.1| homeobox A5 (predicted) [Papio anubis]
156.0 [0..1] [270..1]
HXA5A_TAKRU - Homeobox protein Hox-A5a OS=Takifugu rubripes GN=hoxa5a PE=3 SV=1
156.0 [0..1] [266..1]
gi|114612541 - gi|114612541|ref|XP_001162719.1| PREDICTED: hypothetical protein isoform 1 [Pan troglodytes]
154.0 [0..1] [270..1]

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Predicted Domain #1
Region A:
Residues: [1-192]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG  60
   61 SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP LPCSAVAPSP GSDSHHGGKN 120
  121 SLGNSSGASA NAGSTHISSR EGVGTASAAE EDAPASSEQA GAQSEPSPAP PAQPQIYPWM 180
  181 RKLHISHDNI GG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [193-270]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEGKRARTAY TRYQTLELEK EFHFNRYLTR RRRIEIAHAL CLSERQIKIW FQNRRMKWKK  60
   61 DNKLKSMSMA AAGGAFRP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.0
Match: 1homA
Description: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle