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View Structure Prediction Details

Protein: gi|149033363
Organism: Rattus norvegicus
Length: 270 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|149033363.

Description E-value Query
Range
Subject
Range
gi|15029697 - gi|15029697|gb|AAH11063.1| Homeo box A5 [Mus musculus]
161.0 [0..1] [270..1]
gi|61370212, gi|... - gi|61370212|gb|AAX43455.1| homeobox A5 [synthetic construct], gi|61370206|gb|AAX43454.1| homeobox A5...
159.0 [0..1] [270..1]
gi|72247, gi|387668 - pir||WJHU1C homeotic protein Hox A5 - human, gi|387668|gb|AAA58663.1| HOX 1.3
159.0 [0..1] [270..1]
gi|73976525 - gi|73976525|ref|XP_539487.2| PREDICTED: similar to Homeobox protein Hox-A5 (Hox-1.3) (M2) [Canis fam...
HXA5_BOVIN - Homeobox protein Hox-A5 OS=Bos taurus GN=HOXA5 PE=2 SV=1
gi|170649678 - gi|170649678|gb|ACB21263.1| homeobox A5 (predicted) [Callicebus moloch]
158.0 [0..1] [270..1]
gi|34855875, gi|... - ref|XP_347223.1| similar to homeo domain protein [Rattus norvegicus], ref|XP_342686.1| homeo box A5...
157.0 [0..1] [270..112]
gi|109067082 - gi|109067082|ref|XP_001092687.1| PREDICTED: similar to Homeobox protein Hox-A5 (Hox-1.3) (M2) isofor...
gi|114612539 - gi|114612539|ref|XP_519011.2| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes]
gi|160904219 - gi|160904219|gb|ABX52203.1| homeobox A5 (predicted) [Papio anubis]
156.0 [0..1] [270..1]
HXA5A_TAKRU - Homeobox protein Hox-A5a OS=Takifugu rubripes GN=hoxa5a PE=3 SV=1
156.0 [0..1] [266..1]
gi|114612541 - gi|114612541|ref|XP_001162719.1| PREDICTED: hypothetical protein isoform 1 [Pan troglodytes]
154.0 [0..1] [270..1]

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Predicted Domain #1
Region A:
Residues: [1-192]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG  60
   61 SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP LPCSAVAPSP GSDSHHGGKN 120
  121 SLGNSSGASA NAGSTHISSR EGVGTASAAE EDAPASSEQA GAQSEPSPAP PAQPQIYPWM 180
  181 RKLHISHDNI GG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [193-270]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEGKRARTAY TRYQTLELEK EFHFNRYLTR RRRIEIAHAL CLSERQIKIW FQNRRMKWKK  60
   61 DNKLKSMSMA AAGGAFRP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.0
Match: 1homA
Description: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle