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View Structure Prediction Details

Protein: ECP5_MOUSE
Organism: Mus musculus
Length: 155 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ECP5_MOUSE.

Description E-value Query
Range
Subject
Range
gi|26344600, gi|... - gi|31981520|ref|NP_035401.2| pancreatic ribonuclease [Mus musculus], gi|26344600|dbj|BAC35949.1| unn...
214.0 [0..1] [154..1]
RNAS1_MUSSA - Ribonuclease pancreatic OS=Mus saxicola GN=Rnase1 PE=2 SV=1
213.0 [0..1] [154..1]
RNS1A_RATEX - Ribonuclease pancreatic alpha-type OS=Rattus exulans PE=3 SV=1
213.0 [0..1] [154..1]
gi|18376502 - gi|18376502|emb|CAC86435.1| pancreatic ribonuclease alpha [Berylmys bowersi]
211.0 [0..1] [154..1]
RNAS1_URARU - Ribonuclease pancreatic OS=Uranomys ruddi GN=RNASE1 PE=2 SV=1
210.0 [0..1] [154..1]
RNAS1_ABRJE - Ribonuclease pancreatic OS=Abrothrix jelskii GN=RNASE1 PE=2 SV=1
207.0 [0..1] [153..1]
RNAS1_MUSPA - Ribonuclease pancreatic OS=Mus pahari GN=Rnase1 PE=2 SV=1
206.0 [0..1] [154..1]
RNAS1_NIVCR - Ribonuclease pancreatic OS=Niviventer cremoriventer GN=RNASE1 PE=2 SV=1
205.0 [0..1] [154..1]
RNAS1_LAGLA - Ribonuclease pancreatic OS=Lagothrix lagotricha GN=RNASE1 PE=3 SV=1
205.0 [0..19] [154..21]
RNAS1_ATEGE - Ribonuclease pancreatic OS=Ateles geoffroyi GN=RNASE1 PE=3 SV=1
205.0 [0..19] [154..21]

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Predicted Domain #1
Region A:
Residues: [1-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLKLLESRL CLLLLLGLVL TLVSCQRPTP SQKFAIQHIY KKSSPKCDDA MRVVNKYTGK  60
   61 CKDLNTFLHT TFADVVRVCH NPPKTCKDGT SPNCHDSSSK VSVTICKLTK RARNYTHCRY 120
  121 KTTGGKKSYT VACNPRTPKD RPTYPVVPVH LDRLF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.30103
Match: 1c0bA
Description: Ribonuclease A (also ribonuclease B, S)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribonuclease activity 5.85331424069985 bayes_pls_golite062009
heparin binding 3.58380117228366 bayes_pls_golite062009
glycosaminoglycan binding 3.52657253958322 bayes_pls_golite062009
pattern binding 3.51086739633778 bayes_pls_golite062009
polysaccharide binding 3.37691389332571 bayes_pls_golite062009
carbohydrate binding 2.89194903289209 bayes_pls_golite062009
receptor binding 2.83930957790412 bayes_pls_golite062009
nuclease activity 2.6143896131521 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.55451546641661 bayes_pls_golite062009
hydrolase activity 2.48814110093195 bayes_pls_golite062009
copper ion binding 2.3834238539949 bayes_pls_golite062009
binding 1.86332796702086 bayes_pls_golite062009
nucleic acid binding 1.54332419426054 bayes_pls_golite062009
catalytic activity 1.25983854650131 bayes_pls_golite062009
cytoskeletal protein binding 1.00514730781388 bayes_pls_golite062009
DNA binding 0.985618596844344 bayes_pls_golite062009
transition metal ion binding 0.977421234494784 bayes_pls_golite062009
protein binding 0.880608437208074 bayes_pls_golite062009
endonuclease activity 0.716350502288269 bayes_pls_golite062009
ion binding 0.398016681127412 bayes_pls_golite062009
endoribonuclease activity 0.390109603204743 bayes_pls_golite062009
cation binding 0.386926137029917 bayes_pls_golite062009
metal ion binding 0.386926137029917 bayes_pls_golite062009
RNA binding 0.25908919754622 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle