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View Structure Prediction Details

Protein: gi|109093780
Organism: Macaca mulatta
Length: 590 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|109093780.

Description E-value Query
Range
Subject
Range
gi|148708549, gi... - gi|56800297|emb|CAI35277.1| neurofibromatosis 2 [Mus musculus], gi|56206832|emb|CAI25029.1| neurofib...
5.0E-45 [1..590] [1..591]
gi|109093778 - gi|109093778|ref|XP_001106489.1| PREDICTED: similar to neurofibromin 2 isoform 1 isoform 2 [Macaca m...
6.0E-45 [1..586] [1..586]
MERL_PAPAN - Merlin OS=Papio anubis GN=NF2 PE=3 SV=1
gi|27819130 - gi|27819130|gb|AAO23133.1| merlin [Papio anubis anubis]
9.0E-45 [1..579] [1..579]
gi|3980301 - gi|3980301|emb|CAA76993.1| NF2 protein [Homo sapiens]
1.0E-44 [1..579] [1..579]
gi|73994949 - gi|73994949|ref|XP_865421.1| PREDICTED: similar to neurofibromin 2 isoform 2 isoform 4 [Canis famili...
1.0E-44 [1..590] [1..591]

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Predicted Domain #1
Region A:
Residues: [1-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW  60
   61 FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL 120
  121 QVKKQILDEK IY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.69897
Match: 1h4rA
Description: Merlin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.11253399564789 bayes_pls_golite062009
protein binding 2.9188688008729 bayes_pls_golite062009
binding 2.786655943372 bayes_pls_golite062009
tubulin binding 2.07056129877098 bayes_pls_golite062009
transcription regulator activity 1.96195140258726 bayes_pls_golite062009
microtubule binding 1.72240474615301 bayes_pls_golite062009
nucleic acid binding 1.69351004422121 bayes_pls_golite062009
DNA binding 1.68336605464756 bayes_pls_golite062009
protein kinase activity 1.41746981361756 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.191157934179 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.18332168379334 bayes_pls_golite062009
kinase activity 1.15417305589174 bayes_pls_golite062009
signal transducer activity 1.05682194741929 bayes_pls_golite062009
molecular transducer activity 1.05682194741929 bayes_pls_golite062009
protein serine/threonine kinase activity 0.673589832597734 bayes_pls_golite062009
structural constituent of ribosome 0.599634454232833 bayes_pls_golite062009
structural molecule activity 0.576819726104993 bayes_pls_golite062009
transferase activity 0.554254297988574 bayes_pls_golite062009
small conjugating protein ligase activity 0.50926661172412 bayes_pls_golite062009
GTPase regulator activity 0.334601927012824 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.315664702789604 bayes_pls_golite062009
enzyme binding 0.240262781026149 bayes_pls_golite062009
enzyme regulator activity 0.162163146322721 bayes_pls_golite062009
structure-specific DNA binding 0.0986679676607074 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.056123046743155 bayes_pls_golite062009
receptor binding 0.020939932812017 bayes_pls_golite062009
protein tag 0.00311613478935058 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [133-590]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPPEASVLLA SYAVQAKYGD YDPSVHKRGF LAQEELLPKR VINLYQMTPE MWEERITAWY  60
   61 AEHRGRARDE AEMEYLKIAQ DLEMYGVNYF AIRNKKGTEL LLGVDALGLH IYDPENRLTP 120
  121 KISFPWNEIR NISYSDKEFT IKPLDKKIDV FKFNSSKLRV NKLILQLCIG NHDLFMRRRK 180
  181 ADSLEVQQMK AQAREEKARK QMERQRLARE KQMREEAERT RDELERRLLQ MKEEATMANE 240
  241 ALMRSEETAD LLAEKAQITE EEAKLLAQKA AEAEQEMQRI KATAIRTEEE KRLMEQKVLE 300
  301 AEVLALKMAE ESERRAKEAD QLKQDLQEAR EAERRAKQKL LEIATKPTYP PMNPIPAPLP 360
  361 PDIPSFNLIG DSLSFDFKDT DMKRLSMEIE KEKVEYMEKS KHLQEQLNEL KTEIEALKLK 420
  421 ERETALDILH NENSDRGGSS KHNTIKKPQA QGRRPICI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.30103
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle