YRC Public Data Repository - Protein Structure Prediction

Protein:	TYW1_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	688 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TYW1_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|73957625 - gi\|73957625\|ref\|XP_536836.2\| PREDICTED: similar to radical S-adenosyl methionine and flavodoxin doma...	390.0	[0..31]	[669..22]
TYW1_MOUSE - S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase OS=Mus musculus GN=Tyw1 PE=1 SV=1	361.0	[0..50]	[669..37]
TYW1_YEAST - S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase OS=Saccharomyces cerevisiae (strai... gi\|151942594 - gi\|151942594\|gb\|EDN60940.1\| tRNA-YW synthesizing protein [Saccharomyces cerevisiae YJM789] TYW1 - Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adja... gi\|190407756 - gi\|190407756\|gb\|EDV11021.1\| hypothetical protein SCRG_02292 [Saccharomyces cerevisiae RM11-1a]	359.0	[0..32]	[680..148]
TYW1_ARATH - S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase OS=Arabidopsis thaliana GN=TYW1 PE...	359.0	[0..79]	[673..40]
gi\|85104851 - gi\|85104851\|ref\|XP_961821.1\| hypothetical protein NCU06633 [Neurospora crassa OR74A] gi\|28923398, gi\|... - gi\|32412015\|ref\|XP_326488.1\| hypothetical protein [Neurospora crassa], gi\|28923398\|gb\|EAA32585.1\| hy...	359.0	[0..7]	[666..317]
gi\|115628092, gi... - gi\|115628092\|ref\|XP_782500.2\| PREDICTED: similar to radical S-adenosyl methionine and flavodoxin dom...	352.0	[0..43]	[669..34]
gi\|44984309 - gi\|44984309\|gb\|AAS53275.1\| AFL099Wp [Ashbya gossypii ATCC 10895] gi\|45198422, gi\|... - gi\|45198422\|ref\|NP_985451.1\| AFL099Wp [Ashbya gossypii ATCC 10895], gi\|44984309\|gb\|AAS53275.1\| AFL09...	351.0	[0..36]	[679..128]
gi\|109497239, gi... - gi\|197246847\|gb\|AAI68924.1\| TRNA-yW synthesizing protein 1 homolog (S. cerevisiae) [Rattus norvegicu...	347.0	[0..63]	[669..48]

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Predicted Domain #1

Region A:
Residues: [1-88]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGYSLGYIGE HWEEYRAVLY IVLLLPVLIH FLIRRKTQLS NSDKSSEKKD EVKKQREVKR  60
   61 FKRVGKRGKI GSPSSSIRKQ NDTIDWKN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.522879
Match:	1zoaA
Description:	No description for 1zoaA was found.

Predicted Domain #2

Region A:
Residues: [89-341]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPLCVFYSTL GGTAERYAKQ VHEELSSLLQ RDDIQLLNLD YVDLSEYFVS CPENAIYLVV  60
   61 LPSYEIESSI DYYLSSLQES FSDFRVPKDP LHGLSGYAVF GLGDMENYPG DKFCYQAIQA 120
  121 DKWIKKLGAR RLAPLGVVNT QLAPTAQIDA LLQWTRSVAE CLKNGTLLKI GNTDSLSSDV 180
  181 MDVEDMGSMM AKAKAEAALP VGTKEMVSTE SPTYKALTKQ GYSVVGSHSG VKICRWTKSA 240
  241 MRGRGFCYKY SFY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.69897
Match:	1j9zA
Description:	NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	0.62629924591908	bayes_pls_golite062009
binding	0.523120840489436	bayes_pls_golite062009
catalytic activity	0.275631658558537	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [342-688]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIRSHLCMEA TPSLACANKC TFCWRHGTNP VGTSWRWKVD PPEMILQGIL KAHYAKLKLM  60
   61 KGVPGVLPDR YEEASRVRHC ALSLVGEPIF YPYINEFVSM LHEREISSFL VTNAQHPEAL 120
  121 RNMGMVTQLY VSVDASTKQS LKSVDRPLFK DFWERMLTCL EILREKRQRT VYRMTLVKGF 180
  181 NMEQIKEYTE LIRLGVPCFI EVKGVTYSGN SDQSPLTMKN VPYYEEVIDF VKKLIEYIDI 240
  241 HLQDLGVRYE IAAEHAHSCS ILVAQTAFKK DGHWHTHIDY PKFFELIRTK KDFGPFDYMA 300
  301 STPDFAMFGN GGFSPEDTRF HRKKKTQTSK PISATISETA TISEAAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.69897
Match:	1tv7A
Description:	Structure of the S-adenosylmethionine dependent Enzyme MoaA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.48331922124015	bayes_pls_golite062009
transferase activity	0.685192555939835	bayes_pls_golite062009
binding	0.60397276396442	bayes_pls_golite062009
protein binding	0.124485878765261	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: