YRC Public Data Repository - Protein Structure Prediction

Protein:	RICTR_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	1309 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RICTR_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|46116570, gi\|... - gi\|46116570\|ref\|XP_384303.1\| hypothetical protein FG04127.1 [Gibberella zeae PH-1], gi\|42549486\|gb\|E...	1473.0	[0..6]	[1291..60]
gi\|145010433, gi... - gi\|39939912\|ref\|XP_359493.1\| hypothetical protein MGG_05284 [Magnaporthe grisea 70-15], gb\|EAA52592....	1429.0	[0..6]	[1300..73]
gi\|28924767, gi\|... - gi\|32416164\|ref\|XP_328560.1\| hypothetical protein [Neurospora crassa], gi\|28924767\|gb\|EAA33879.1\| co... gi\|85109843 - gi\|85109843\|ref\|XP_963115.1\| hypothetical protein NCU07854 [Neurospora crassa OR74A]	1427.0	[0..7]	[1298..77]
gi\|49097270, gi\|... - gi\|67539576\|ref\|XP_663562.1\| hypothetical protein AN5958.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	1409.0	[0..18]	[1289..92]
gi\|114196582, gi... - gi\|115384686\|ref\|XP_001208890.1\| conserved hypothetical protein [Aspergillus terreus NIH2624], gi\|11...	1303.0	[0..34]	[1300..112]
gi\|159129453 - gi\|159129453\|gb\|EDP54567.1\| cytosolic regulator Pianissimo, putative [Aspergillus fumigatus A1163] gi\|66853017, gi\|... - gi\|71001396\|ref\|XP_755379.1\| cytosolic regulator Pianissimo [Aspergillus fumigatus Af293], gi\|668530...	1293.0	[0..34]	[1297..113]
TSC11_YEAST - Target of rapamycin complex 2 subunit TSC11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... TSC11 - Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates...	1274.0	[0..5]	[1306..93]
gi\|169783478 - gi\|169783478\|ref\|XP_001826201.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83774945 - gi\|83774945\|dbj\|BAE65068.1\| unnamed protein product [Aspergillus oryzae]	1266.0	[0..34]	[1290..113]
gi\|116191659, gi... - gi\|88181460\|gb\|EAQ88928.1\| hypothetical protein CHGG_05547 [Chaetomium globosum CBS 148.51], gi\|1161...	1266.0	[0..7]	[1294..177]
gi\|49080678, gi\|... - gi\|71024265\|ref\|XP_762362.1\| hypothetical protein UM06215.1 [Ustilago maydis 521], ref\|XP_403830.1\| ...	1248.0	[0..157]	[1285..268]

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Predicted Domain #1

Region A:
Residues: [1-170]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPVRRGQTD TALDISSHAK TNGDFIKKMN TTDSKRLKLL EDLKGKLEVE CKIRDGAETL  60
   61 LQVFDTNFKK ETKERKEMLK KKCTDELESS KKKIEELVSS IESFQGENGE AKTGSTSLTR 120
  121 SASATVSRKS SLQEKYSTRF SYKAGCSDSC SVTVSGTGEL IGPTRNAHSN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.69897
Match:	1ri9A
Description:	Structure of a helically extended SH3 domain of the T cell adapter protein ADAP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	3.06905798270146	bayes_pls_golite062009
cytoskeletal protein binding	2.21254869336424	bayes_pls_golite062009
protein binding	2.08632303609243	bayes_pls_golite062009
actin binding	1.79651396322487	bayes_pls_golite062009
actin filament binding	1.03574214978228	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [171-252]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTPTVIQRID FENVNEKNNS SSEDTQPNGK RPSSLQSNFS QFPLNPWLDN IYKACLEGSM  60
   61 KDVIDSSNNL CEYLHEHSDP AY

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.02
Match:	1xqrA
Description:	Crystal structure of the HspBP1 core domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [253-990]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKNFSLITPT ILSMLELNVS EVTASVYRLL RHLFLDATAF SCCQMLNLPW ILSKSLLSGT  60
   61 DAYQIEREQA FRLIRTLYFL SSTEGHEDYL SGITRTIISI CEHVSDVSRG IAVETLIELM 120
  121 IIRPKILFKA NGLRVLMISL IDGSISENLA ASAALALVYL LDDPESACYV NLPYDIGILL 180
  181 SPFTSSSSRD TFNSSEEQSE QAAKAMKSSA KVASVLLNSW SGLLALSTND FQALRSIVDT 240
  241 LRVPSFAPRS DVIDLFFLIF QVEYSSWSES FLAGKRLTVV KNQAVSNDDN INMVNIPDGS 300
  301 NKKYMSLRQH FTAVLLFIFL ELGLVESIVC MIRASDDPSA SRKATYLLGE VLRLSDELLP 360
  361 IHLGAKIQSL PSLFNMASQF TAEDRFVATS VLQSIESLNR VKFHSATQPF SQTTSLLFKE 420
  421 QKTDGSFRGQ RQVEHVKLKM GMQIDDSHFR SMLAETNVLA TKNYQKWRWD TLVQIMEGPL 480
  481 LSPKRIDETL RTTKFMRRLL AFYKPFSNRF SSIQNTKPNQ KFIKVGCLVF RTLLANPEGV 540
  541 KYLSESKVIK QIAESLSQID GYSEQVSEPI FSNSRLQKTL THGYFPMLKV LSSQKEGHAI 600
  601 MERWRIFTTL YHLTELRNRD DLIIIFLTNL DYRLEGHTRI IFSKALNTGQ QAVRLTATKH 660
  661 LAALINSESA NDNLNHWAIS LLIFQLYDPC LEVCKTAVKV LNEVCARNEN LLAQVVQLQP 720
  721 SLAHLGEIGS PLLLRFLA

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.08
Match:	2ie3A
Description:	No description for 2ie3A was found.

Predicted functions:

Term	Confidence	Notes
binding	2.96084803796407	bayes_pls_golite062009
nucleic acid binding	2.39117996950187	bayes_pls_golite062009
transcription regulator activity	1.93307188158984	bayes_pls_golite062009
DNA binding	1.77969838181048	bayes_pls_golite062009
protein binding	1.61131270705552	bayes_pls_golite062009
transcription factor activity	1.02508422532466	bayes_pls_golite062009
kinase activity	0.927598860906311	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.913976209573995	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.824446524918749	bayes_pls_golite062009
enzyme regulator activity	0.632985761187158	bayes_pls_golite062009
protein kinase activity	0.632472431834211	bayes_pls_golite062009
transferase activity	0.574559666809629	bayes_pls_golite062009
cytoskeletal protein binding	0.37240198519167	bayes_pls_golite062009
actin binding	0.171976353606808	bayes_pls_golite062009
protein serine/threonine kinase activity	0.109457212542021	bayes_pls_golite062009
protein phosphatase binding	0.0831993958662147	bayes_pls_golite062009
transcription activator activity	0.061709024440191	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.0342115143082778	bayes_pls_golite062009
GTPase regulator activity	0.0272200107208467	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [991-1117]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTVGFHYLSE INFIEHELDN WYHHRNIDYV DLLEQNFFLS FVSNLKIIDK KNNEPDENIL  60
   61 PLHFYGELVK SPQGCEVLES SGHFESFMGT LVEFYDKPLG NEAIRQLKSA LWAIGNIGKT 120
  121 DQGITFL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [1118-1208]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INHDTIPLIV KYAENSLIPT VRGTAYFVLG LISRTSKGVE ILESLHWYSL MSLMGTSQGI  60
   61 CIPRHAGQVL STPRRNVEFV NERVPTPEFS S

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [1209-1309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLSSLTNSER EVIRLVSNLS NHVLTNESAR QLTKIRSKNA KVFSSKRLVK ACMTILGKFH  60
   61 YRVQIQQFVF ELFPYSVLLS SSTSQDLNES PSRPNNLSIS A

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.331	0.154	conjugation with cellular fusion	c.3.1	FAD/NAD(P)-binding domain
View	Download	0.385	0.153	conjugation with cellular fusion	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.463	0.064	conjugation with cellular fusion	d.211.1	Ankyrin repeat
View	Download	0.328	0.032	conjugation with cellular fusion	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.366	0.027	conjugation with cellular fusion	a.118.9	ENTH/VHS domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: