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View Structure Prediction Details

Protein: gi|109114201
Organism: Macaca mulatta
Length: 243 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|109114201.

Description E-value Query
Range
Subject
Range
gi|21755659 - gi|21755659|dbj|BAC04730.1| unnamed protein product [Homo sapiens]
4.0E-45 [1..243] [1..243]
gi|57091665 - gi|57091665|ref|XP_548179.1| PREDICTED: similar to homeo box B8 [Canis familiaris]
5.0E-45 [1..243] [1..243]
gi|109491742 - gi|109491742|ref|XP_001081339.1| PREDICTED: similar to Homeobox protein Hox-B9 (Hox-2.5) [Rattus nor...
3.0E-43 [1..243] [442..684]
gi|149053980, gi... - gi|27689057|ref|XP_220888.1| PREDICTED: homeo box B8 [Rattus norvegicus], gi|149053980|gb|EDM05797.1...
HXB8_MOUSE - Homeobox protein Hox-B8 OS=Mus musculus GN=Hoxb8 PE=2 SV=2
2.0E-42 [1..243] [1..243]
gi|109114199 - gi|109114199|ref|XP_001089161.1| PREDICTED: similar to homeobox B9 isoform 3 [Macaca mulatta]
6.0E-42 [1..243] [305..547]
HXB8A_DANRE - Homeobox protein Hox-B8a OS=Danio rerio GN=hoxb8a PE=2 SV=1
2.0E-41 [1..242] [1..241]
gi|45382501, gi|... - gi|45382501|ref|NP_990242.1| homeo box B8 [Gallus gallus], gi|4099016|gb|AAD09228.1| Hoxb-8 [Gallus ...
3.0E-41 [1..243] [1..241]
HXB8A_TAKRU - Homeobox protein Hox-B8a OS=Takifugu rubripes GN=hoxb8a PE=3 SV=1
1.0E-35 [1..220] [1..222]

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Predicted Domain #1
Region A:
Residues: [1-143]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH PSQIQEFYHG  60
   61 PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ DPDLVQYADC KLAAASGLGE 120
  121 EAEGSEQSPS PTQLFPWMRP QAA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [144-243]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGRRRGRQTY SRYQTLELEK EFLFNPYLTR KRRIEVSHAL GLTERQVKIW FQNRRMKWKK  60
   61 ENNKDKFPSS KCEQEELEKQ KLERAPEAAD EGDAQKGDKK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.39794
Match: 1homA
Description: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle