YRC Public Data Repository - Protein Structure Prediction

Protein:	LEUC_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	758 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LEUC_SCHPO.

Description	E-value	Query Range	Subject Range
LEUC_RHIPU - 3-isopropylmalate dehydratase OS=Rhizomucor pusillus GN=LEUA PE=3 SV=1	909.0	[0..7]	[758..1]
gi\|29788133 - gi\|29788133\|emb\|CAD68165.1\| 3-isopropylmalate dehydratase [Cloning vector pEUKA11] gi\|29788127 - gi\|29788127\|emb\|CAD68161.1\| putative alpha-isopropylmalate isomerase [Mucor circinelloides f. lusita...	907.0	[0..7]	[758..1]
gi\|46136147, gi\|... - gi\|46136147\|ref\|XP_389765.1\| hypothetical protein FG09589.1 [Gibberella zeae PH-1], gi\|42554303\|gb\|E...	892.0	[0..1]	[758..1]
gi\|28918554, gi\|... - gi\|40882238\|emb\|CAF06063.1\| probable 3-isopropylmalate dehydratase [Neurospora crassa], gi\|32406250\|... gi\|85085243 - gi\|85085243\|ref\|XP_957462.1\| 3-isopropylmalate dehydratase [Neurospora crassa OR74A]	890.0	[0..1]	[758..1]
LEUC_RHINI - 3-isopropylmalate dehydratase OS=Rhizopus niveus GN=LEU1 PE=3 SV=1	885.0	[0..7]	[758..1]
gi\|40739205, gi\|... - gi\|67539432\|ref\|XP_663490.1\| hypothetical protein AN5886.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	880.0	[0..1]	[755..1]
gi\|83769825 - gi\|83769825\|dbj\|BAE59960.1\| unnamed protein product [Aspergillus oryzae] gi\|169774989 - gi\|169774989\|ref\|XP_001821962.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|238496375, gi... - gi\|238496375\|ref\|XP_002379423.1\| 3-isopropylmalate dehydratase, putative [Aspergillus flavus NRRL335...	877.0	[0..1]	[758..1]
LEU2_PHYBL, LEUC... - 3-isopropylmalate dehydratase OS=Phycomyces blakesleeanus GN=leu1 PE=3 SV=2, 3-isopropylmalate dehyd... LEUC_PHYB8 - 3-isopropylmalate dehydratase OS=Phycomyces blakesleeanus (strain ATCC 8743b / FGSC 10004 / NBRC 330...	876.0	[0..7]	[758..1]
gi\|90299828, gi\|... - gi\|90299828\|gb\|EAS29459.1\| hypothetical protein CIMG_08205 [Coccidioides immitis RS], gi\|119178810\|r...	872.0	[0..1]	[758..1]

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Predicted Domain #1

Region A:
Residues: [1-758]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPSVASPKT LYDKVWDSHV VDLQEDGTCL LYIDRHLIHE VTSPQAFEGL RTAGRKVRHP  60
   61 ELALATVDHN IPTDPRKDMK DIASFIHQPD SRTQVLALEN NIKEFGLTYY GMNDRRQGIV 120
  121 HVIGPEQGFT LPGTTLVCGD SHTSTHGAFG ALAFGIGTSE VEHVLATQTI LQRKSKNMRI 180
  181 RVNGKLPEGI ASKDLILHII GVIGTAGGTG SVIEFCGEAI EGLSMEARMS MCNMSIEAGA 240
  241 RAGMIAPDAT TFEYVKNRPL APKGDDWEQA VAYWKTLRSD ENAKYDIEVE INAADVLPTV 300
  301 TWGTSPQDVI PINGNIPDPA HVKDNVRAAS IQRSLEYMGL KPNTSIVSYP IDKVFIGSCT 360
  361 NSRIEDLRLA AAVVKGRKVA ANVKDAMIVP GSGLVKKMAE AEGLDQIFIE AGFDWREAGC 420
  421 SMCLGMNPDQ LKPYERCAST SNRNFEGRQG AKGRTHLVSP AMAAAAAIKG HLCNVREFFG 480
  481 DVSNGSPSII TNKNYDPSHD VEGDIGLSVD DATDAVTDAD GIATNVAGSV SSGSAGIPKF 540
  541 TVVEGIAAPL PMANVDTDKI IPKQFLKTIK RTGLGQFAFY EIRYDADGKE IPDFVLNREP 600
  601 YRHATVLVAH DNFGCGSSRE HAPWALNDFG IRVIIAPSFA DIFFNNCFKN GMLPIPTPIE 660
  661 QVNDMMKAAE NQVKFSVDLV NQTITYGDKQ VKFDVEPFRK HCLVNGLDDI GLTLQKETMI 720
  721 DAFEAAREEN FPWMNIKRSR ARLSPVKSNK QSSSRNDW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	2b3xA
Description:	Structure of an orthorhombic crystal form of human cytosolic aconitase (IRP1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-isopropylmalate dehydratase activity	11.6597692115322	bayes_pls_golite062009
aconitate hydratase activity	5.86356477922338	bayes_pls_golite062009
structural constituent of ribosome	2.93956285477489	bayes_pls_golite062009
catalytic activity	2.4040324437254	bayes_pls_golite062009
carbon-oxygen lyase activity	2.08349115784849	bayes_pls_golite062009
hydro-lyase activity	2.04845291489052	bayes_pls_golite062009
lyase activity	2.0080619912194	bayes_pls_golite062009
nucleic acid binding	1.67435647648998	bayes_pls_golite062009
binding	1.24981419049889	bayes_pls_golite062009
DNA binding	1.05282906893033	bayes_pls_golite062009
structural molecule activity	0.870913754566634	bayes_pls_golite062009
mRNA binding	0.52321922280827	bayes_pls_golite062009
RNA binding	0.41480744631042	bayes_pls_golite062009
iron-sulfur cluster binding	0.239736179000069	bayes_pls_golite062009
metal cluster binding	0.239736179000069	bayes_pls_golite062009
protein binding	0.232638130896339	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: