| Protein: | Mhcl-PB |
| Organism: | Drosophila melanogaster |
| Length: | 2194 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Mhcl-PB.
| Description | E-value | Query Range |
Subject Range |
|
|
1155.0 | [0..1] | [2140..1] |
|
Region A: Residues: [1-110] |
1 11 21 31 41 51
| | | | | |
1 MFNFMKKSAG DEDKERRKRE KKLRKEAKGT SGGPGMGGVT GVTGSMSTDE LLRLDEVRRS 60
61 LKIRGRRKEK EKLPSGITAD YSADFFAALN ADANGGSNGG AVGAADPEQD
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [111-326] |
1 11 21 31 41 51
| | | | | |
1 RGNEEIVASV MTHIESRASN GAGVSVNYSE VTHSLLSGGL KNRFLPPIPP KPPKRGILKG 60
61 SRSNMTNVHE EISFAGSAGG AGGTPEMLLR NTFQNESLYE GAARGAGSIG SNSSQHGTSF 120
121 TSVESLRSDG EQTGGQQRAM TLPANARYGA LPQGNSQGSH LHVLTSPSPS ADSLTDTTNS 180
181 SFATPPFSLS PVGESQGIDR WARVHAFEDV ELPLPP
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [327-484] |
1 11 21 31 41 51
| | | | | |
1 VQLVKLPPPR QLVIRRQKSP RQDFGFSLRK AICLDRTESL TSPIFRPVIF AEPGAGGGAT 60
61 GLLPGDRLIK VNGTPVGELP REIIIEMIRN SGEAVTVEVQ PVAELVELSK RCMAPSTATV 120
121 EEIDHSITNG NCNTLRRSAS KRFKRQSRHE NGNGGGEE
|
| Detection Method: | |
| Confidence: | 24.045757 |
| Match: | 1q3oA |
| Description: | Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| actinin binding | 6.63491164831411 | bayes_pls_golite062009 |
| structural constituent of muscle | 4.49823022706389 | bayes_pls_golite062009 |
| alpha-actinin binding | 4.16023108909992 | bayes_pls_golite062009 |
| actin binding | 3.71885072001885 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 3.60106431937699 | bayes_pls_golite062009 |
| binding | 3.2595117613307 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 2.92578423185022 | bayes_pls_golite062009 |
| protein binding | 2.35875654816667 | bayes_pls_golite062009 |
| actin filament binding | 1.91421788587359 | bayes_pls_golite062009 |
| myosin binding | 1.34447751574529 | bayes_pls_golite062009 |
| receptor binding | 1.19273986711251 | bayes_pls_golite062009 |
| transporter activity | 1.18978519116375 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.07211582292329 | bayes_pls_golite062009 |
| PDZ domain binding | 0.87883331498113 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.755223974149211 | bayes_pls_golite062009 |
| beta-catenin binding | 0.740091060781601 | bayes_pls_golite062009 |
| structural molecule activity | 0.710830054334763 | bayes_pls_golite062009 |
| molecular transducer activity | 0.663245640718285 | bayes_pls_golite062009 |
| signal transducer activity | 0.663245640718285 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.549085929250683 | bayes_pls_golite062009 |
| hydrolase activity | 0.534910002338727 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 0.403457741099606 | bayes_pls_golite062009 |
| transcription regulator activity | 0.387065538161985 | bayes_pls_golite062009 |
| protein domain specific binding | 0.30840185305841 | bayes_pls_golite062009 |
| active transmembrane transporter activity | 0.252733105474942 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.182094987832726 | bayes_pls_golite062009 |
|
Region A: Residues: [485-1716] |
1 11 21 31 41 51
| | | | | |
1 GGAKGVGHDL EADVADASQP ERVWLVHRGG FTAAIRLPTA SSGRDEENKL SLRLLHNGEQ 60
61 LTVDEDDVEK QNSPALDLVE DICELKYLNE ASVLHCLRQR YASNLIHTKA GPTLLVVNPM 120
121 APLSLYSEKV VSMFRGCKTE DMPPHVYSLA QTAYRSLVET RRDQSLIFMG RSGSGKSTSF 180
181 KHALNYLALA AGAYNNFINA EKVNALCTIL EAFGNTKTCL NSNATRMTQL LSLDFDQTGQ 240
241 IASASLQVLL PERQRAGRRL GHEHSFHIMT RLLAGAAGLL QKELHLENIT SEDSHPFISL 300
301 SQKLEDRHRA ANDFMRTVQA FETLNIDAKA VRGIWSILAA IYHLGIAGVT KLGTGSTART 360
361 QFANPTAARK ASGLLGVNLE DLSSAAFGLT QPNAPNGGLS PSKSPTSDTG HEWAWECLEA 420
421 LVIGLYSEAL AAVVALINRQ ICTSSHTIAS IMLIDTPGFQ NPASCGQQVG ATLADLRHNY 480
481 LQERLQMLFH HTTLVAPRDR YAQELVEIEM DLASECHPGP LISLIDKAPQ NHVVRSSQRD 540
541 LREHDRRGML WLLDEEAIYP NSNDDTFLER LFSHYGDREH HSLLRKCAGP RQFVLHHLQG 600
601 TNPVLYAVDG WVRHSREHPG IRNAVSLLQD SSREEINRLY IGSLTRGSGA MVFCGSFAGL 660
661 EGTQSLRRVS SIRRSFTTAG VKRNSIMLQV KFTVDGIIDT LRRTGTHFVH CYLLQHNAGK 720
721 HTKYTANGSP SSAAGQVSSE EEMVNVPLLR SQLRGSQVLE AARLHRLGFP ESVPLLEFVR 780
781 RFGLLAGDLA SNKDVSVEQI LAVNELDVAS YRIGPSQILF RSGVLSELEA KRDVLLSDRI 840
841 IQLQAFCRGY LARKKMSQRR VQELAVRCIQ RNVKAFLAVR DWPWWRLLVR VTPLLNVHRT 900
901 EEQLKTANEE LLMLRAKLEK IECDRSEVKA ENQKLEAKLS ELTVDLAEER STAHIATERL 960
961 EAETAERLKL EKELGDQTNK VKNLQETTEK LEMELICAKS DLNGISEDED AENEDGVGGG1020
1021 VYKLKYERVA RELEFTKRRL HTQHEHDLEQ LVALKKHLEM KLSDAYEEVV EQRQVVGQWK1080
1081 RKAQKMTNEM NDLRMLLEEQ NARNNLLEKK QRKFDAECQS LQDAVRQERQ AKERYGREKD1140
1141 VLQAEKFTLE QTLADTRLDL EFKEEKLASL QRELEEMTFG GGTEEEFAQL RRSKNETERR1200
1201 AKEQEEELDE MAGQIQLLEQ AKLRLEMTLE TM
|
| Detection Method: | |
| Confidence: | 1000.0 |
| Match: | 1i84S |
| Description: | Heavy meromyosin subfragment |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1717-2194] |
1 11 21 31 41 51
| | | | | |
1 RKEARRESQQ RDEELEEVRG NGYKKIKALE CQLETEHEER TLLLREKHEL ERRLSSMEDR 60
61 DRVDRDAEEA LNQKLRRDLR KYKALLKDAQ TQLERLKADT PGKTLIRQLR NQLEDAESAR 120
121 SLAMKARQTA EAELTEVQAM FDESHRARND AEERANAAHR DRAELQAQIE ENEEELGELM 180
181 KKYSATVKQL NTEQINVSEA EFKLNEMEAE RNNLKEQVAE LQHRLDNVEN LGDPSMAMMS 240
241 KRLELRTKEL ESRLELEQAT RARLEVQVNR HKEALEKLQN EVTQSKMREM QAQDVIKKSQ 300
301 KSLRDMREEF HAVSSREQES LTRRKDLEKK VEQMESEGAA LKNDLRLALQ RIADLQQAME 360
361 EEGEEELSES DESLSSVGSI SDLEDRLRPV HVKRSSQQSL NGSIGGGGGS VVSSTRTVVF 420
421 EKDDNSPRIT VTSPSSPHIH KLALAAKAIP ANKPDTKPAA STRMELTVPA GQHNGHNA
|
| Detection Method: | |
| Confidence: | 5.522879 |
| Match: | 1tr2A |
| Description: | Crystal structure of human full-length vinculin (residues 1-1066) |
Matching Structure (courtesy of the PDB): |
|
