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Protein Overview: Mhcl-PA

General Information:
Name(s) found: Mhcl-PA / FBpp0082683 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • The gene Myosin heavy chain-like is referred to in FlyBase by the symbol Dmel\Mhcl (CG31045, FBgn0026059). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11894245..11923310. It has the cytological map location 89B2-89B3. Based on sequence similarity, it is predicted to have molecular function</span>: ATPase activity, coupled. The biological processes in which it is involved are not known. 6 alleles are reported. The phenotypes of these alleles are annotated with: ventral nerve cord; peripheral nervous system. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2148 amino acids

    Gene Ontology:
    Cellular Component: myosin complex [ISS]
    Biological Process: NONE FOUND
    Molecular Function: ATP binding [IEA]
    protein binding [IEA]
    ATPase activity, coupled [ISS]
    motor activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNFMKKSAG DEDKERRKRE KKLRKEAKGT SGGPGMGGVT GVTGSMSTDE LLRLDEVRRS  60
   61 LKIRGRRKEK EKLPSGITAD YSADFFAALN ADANGGSNGG AVGAADPEQD RGNEEIVASV 120
  121 MTHIESRASN GAGVSVNYSE VTHSLLSGGL KNRFLPPIPP KPPKRGILKG SRSNMTNVHE 180
  181 EISFAGSAGG AGGTPEMLLR NTFQNESLYE GAARGAGSIG SNSSQHGTSF TSVESLRSDG 240
  241 EQTGGQQRAM TLPANARYGA LPQGNSQGSH LHVLTSPSPS ADSLTDTTNS SFATPPFSLS 300
  301 PVGESQGIDR WARVHAFEDV ELPLPPVQLV KLPPPRQLVI RRQKSPRQDF GFSLRKAICL 360
  361 DRTESLTSPI FRPVIFAEPG AGGGATGLLP GDRLIKVNGT PVGELPREII IEMIRNSGEA 420
  421 VTVEVQPVAE LVELSKRCMA PSTATVEEID HSITNGNCNT LRRSASKRFK RQSRHENGNG 480
  481 GGEEGGAKGV GHDLEADVAD ASQPERVWLV HRGGFTAAIR LPTASSGRDE ENKLSLRLLH 540
  541 NGEQLTVDED DVEKQNSPAL DLVEDICELK YLNEASVLHC LRQRYASNLI HTKAGPTLLV 600
  601 VNPMAPLSLY SEKVVSMFRG CKTEDMPPHV YSLAQTAYRS LVETRRDQSL IFMGRSGSGK 660
  661 STSFKHALNY LALAAGAYNN FINAEKVNAL CTILEAFGNT KTCLNSNATR MTQLLSLDFD 720
  721 QTGQIASASL QVLLPERQRA GRRLGHEHSF HIMTRLLAGA AGLLQKELHL ENITSEDSHP 780
  781 FISLSQKLED RHRAANDFMR TVQAFETLNI DAKAVRGIWS ILAAIYHLGI AGVTKLGTGS 840
  841 TARTQFANPT AARKASGLLG VNLEDLSSAA FGLTQPNAPN GGLSPSKSPT SDTGHEWAWE 900
  901 CLEALVIGLY SEALAAVVAL INRQICTSSH TIASIMLIDT PGFQNPASCG QQVGATLADL 960
  961 RHNYLQERLQ MLFHHTTLVA PRDRYAQELV EIEMDLASEC HPGPLISLID KAPQNHVVRS1020
 1021 SQRDLREHDR RGMLWLLDEE AIYPNSNDDT FLERLFSHYG DREHHSLLRK CAGPRQFVLH1080
 1081 HLQGTNPVLY AVDGWVRHSR EHPGIRNAVS LLQDSSREEI NRLYIGSLTR GSGAMVFCGS1140
 1141 FAGLEGTQSL RRVSSIRRSF TTAGVKRNSI MLQVKFTVDG IIDTLRRTGT HFVHCYLLQH1200
 1201 NAGKHTKYTA NGSPSSAAGQ VSSEEEMVNV PLLRSQLRGS QVLEAARLHR LGFPESVPLL1260
 1261 EFVRRFGLLA GDLASNKDVS VEQILAVNEL DVASYRIGPS QILFRSGVLS ELEAKRDVLL1320
 1321 SDRIIQLQAF CRGYLARKKM SQRRVQELAV RCIQRNVKAF LAVRDWPWWR LLVRVTPLLN1380
 1381 VHRTEEQLKT ANEELLMLRA KLEKIECDRS EVKAENQKLE AKLSELTVDL AEERSTAHIA1440
 1441 TERLEAETAE RLKLEKELGD QTNKVKNLQE TTEKLEMELI CAKSDLNGIS EDEDAENEDG1500
 1501 VGGGVYKLKY ERVARELEFT KRRLHTQHEH DLEQLVALKK HLEMKLSDAY EEVVEQRQVV1560
 1561 GQWKRKAQKM TNEMNDLRML LEEQNARNNL LEKKQRKFDA ECQSLQDAVR QERQAKERYG1620
 1621 REKDVLQAEK FTLEQTLADT RLDLEFKEEK LASLQRELEE MTFGGGTEEE FAQLRRSKNE1680
 1681 TERRAKEQEE ELDEMAGQIQ LLEQAKLRLE MTLETMRKEA RRESQQRDEE LEEVRGNGYK1740
 1741 KIKALECQLE TEHEERTLLL REKHELERRL SSMEDRDRVD RDAEEALNQK LRRDLRKYKA1800
 1801 LLKDAQTQLE RLKADTPGKT LIRQLRNQLE DAESARSLAM KARQTAEAEL TEVQAMFDES1860
 1861 HRARNDAEER ANAAHRDRAE LQAQIEENEE ELGELMKKYS ATVKQLNTEQ INVSEAEFKL1920
 1921 NEMEAERNNL KEQVAELQHR LDNVENLGDP SMAMMSKRLE LRTKELESRL ELEQATRARL1980
 1981 EVQVNRHKEA LEKLQNEVTQ SKMREMQAQD VIKKSQKSLR DMREEFHAVS SREQESLTRR2040
 2041 KDLEKKVEQM ESEGAALKND LRLALQRIAD LQQAMEEEGE EELSESDESL SSVGSISDLE2100
 2101 DRLRPVHVKR SSQQSLNGSI GGGGGSVVSS TRTVVFEKDD NSPRNNAK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] deduced N/A No confident structure predictions are available.
    2 View Details [112..150] deduced N/A No confident structure predictions are available.
    3 View Details [151..326] deduced N/A No confident structure predictions are available.
    4 View Details [327..487] PSI-BLAST 22.154902 Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization
    5 View Details [488..1714] PSI-BLAST 1000.0 Heavy meromyosin subfragment
    6 View Details [1715..1903] FFAS03 2.1 Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
    7 View Details [1904..2148] PSI-BLAST 12.69897 Tropomyosin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • actin binding
    		•  3.71885072001885 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.60106431937699 bayes_pls_golite062009
  • binding
    		•  3.2595117613307 bayes_pls_golite062009
  • actinin binding
    		•  3.1211918797237 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  2.92578423185022 bayes_pls_golite062009
  • structural constituent of muscle
    		•  2.63065228203638 bayes_pls_golite062009
  • protein binding
    		•  2.35875654816667 bayes_pls_golite062009
  • actin filament binding
    		•  1.91421788587359 bayes_pls_golite062009
  • myosin binding
    		•  1.34447751574529 bayes_pls_golite062009
  • receptor binding
    		•  1.19273986711251 bayes_pls_golite062009
  • transporter activity
    		•  1.18978519116375 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07211582292329 bayes_pls_golite062009
  • PDZ domain binding
    		•  0.87883331498113 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.755223974149211 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.740091060781601 bayes_pls_golite062009
  • structural molecule activity
    		•  0.710830054334763 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.698981445586131 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.663245640718285 bayes_pls_golite062009
  • signal transducer activity
    		•  0.663245640718285 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.549085929250683 bayes_pls_golite062009
  • hydrolase activity
    		•  0.534910002338727 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.403457741099606 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.387065538161985 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.30840185305841 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252733105474942 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.182094987832726 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle