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View Structure Prediction Details

Protein: Mhcl-PA
Organism: Drosophila melanogaster
Length: 2148 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Mhcl-PA.

Description E-value Query
Range		 Subject
Range
Mhcl-PB - The gene Myosin heavy chain-like is referred to in FlyBase by the symbol Dmel\Mhcl (CG31045, FBgn002...
 1254.0 [0..1] [2117..1]

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Predicted Domain #1
Region A:
Residues: [1-111] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNFMKKSAG DEDKERRKRE KKLRKEAKGT SGGPGMGGVT GVTGSMSTDE LLRLDEVRRS  60
   61 LKIRGRRKEK EKLPSGITAD YSADFFAALN ADANGGSNGG AVGAADPEQD R

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [112-150] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNEEIVASVM THIESRASNG AGVSVNYSEV THSLLSGGL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [151-326] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNRFLPPIPP KPPKRGILKG SRSNMTNVHE EISFAGSAGG AGGTPEMLLR NTFQNESLYE  60
   61 GAARGAGSIG SNSSQHGTSF TSVESLRSDG EQTGGQQRAM TLPANARYGA LPQGNSQGSH 120
  121 LHVLTSPSPS ADSLTDTTNS SFATPPFSLS PVGESQGIDR WARVHAFEDV ELPLPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [327-487] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQLVKLPPPR QLVIRRQKSP RQDFGFSLRK AICLDRTESL TSPIFRPVIF AEPGAGGGAT  60
   61 GLLPGDRLIK VNGTPVGELP REIIIEMIRN SGEAVTVEVQ PVAELVELSK RCMAPSTATV 120
  121 EEIDHSITNG NCNTLRRSAS KRFKRQSRHE NGNGGGEEGG A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.154902
Match: 1q3oA
Description: Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 3.71885072001885 bayes_pls_golite062009
cytoskeletal protein binding 3.60106431937699 bayes_pls_golite062009
binding 3.2595117613307 bayes_pls_golite062009
actinin binding 3.1211918797237 bayes_pls_golite062009
ErbB-2 class receptor binding 2.92578423185022 bayes_pls_golite062009
structural constituent of muscle 2.63065228203638 bayes_pls_golite062009
protein binding 2.35875654816667 bayes_pls_golite062009
actin filament binding 1.91421788587359 bayes_pls_golite062009
myosin binding 1.34447751574529 bayes_pls_golite062009
receptor binding 1.19273986711251 bayes_pls_golite062009
transporter activity 1.18978519116375 bayes_pls_golite062009
transmembrane transporter activity 1.07211582292329 bayes_pls_golite062009
PDZ domain binding 0.87883331498113 bayes_pls_golite062009
substrate-specific transporter activity 0.755223974149211 bayes_pls_golite062009
beta-catenin binding 0.740091060781601 bayes_pls_golite062009
structural molecule activity 0.710830054334763 bayes_pls_golite062009
alpha-actinin binding 0.698981445586131 bayes_pls_golite062009
molecular transducer activity 0.663245640718285 bayes_pls_golite062009
signal transducer activity 0.663245640718285 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.549085929250683 bayes_pls_golite062009
hydrolase activity 0.534910002338727 bayes_pls_golite062009
cell adhesion molecule binding 0.403457741099606 bayes_pls_golite062009
transcription regulator activity 0.387065538161985 bayes_pls_golite062009
protein domain specific binding 0.30840185305841 bayes_pls_golite062009
active transmembrane transporter activity 0.252733105474942 bayes_pls_golite062009
structural constituent of cytoskeleton 0.182094987832726 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [488-1714] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGVGHDLEAD VADASQPERV WLVHRGGFTA AIRLPTASSG RDEENKLSLR LLHNGEQLTV  60
   61 DEDDVEKQNS PALDLVEDIC ELKYLNEASV LHCLRQRYAS NLIHTKAGPT LLVVNPMAPL 120
  121 SLYSEKVVSM FRGCKTEDMP PHVYSLAQTA YRSLVETRRD QSLIFMGRSG SGKSTSFKHA 180
  181 LNYLALAAGA YNNFINAEKV NALCTILEAF GNTKTCLNSN ATRMTQLLSL DFDQTGQIAS 240
  241 ASLQVLLPER QRAGRRLGHE HSFHIMTRLL AGAAGLLQKE LHLENITSED SHPFISLSQK 300
  301 LEDRHRAAND FMRTVQAFET LNIDAKAVRG IWSILAAIYH LGIAGVTKLG TGSTARTQFA 360
  361 NPTAARKASG LLGVNLEDLS SAAFGLTQPN APNGGLSPSK SPTSDTGHEW AWECLEALVI 420
  421 GLYSEALAAV VALINRQICT SSHTIASIML IDTPGFQNPA SCGQQVGATL ADLRHNYLQE 480
  481 RLQMLFHHTT LVAPRDRYAQ ELVEIEMDLA SECHPGPLIS LIDKAPQNHV VRSSQRDLRE 540
  541 HDRRGMLWLL DEEAIYPNSN DDTFLERLFS HYGDREHHSL LRKCAGPRQF VLHHLQGTNP 600
  601 VLYAVDGWVR HSREHPGIRN AVSLLQDSSR EEINRLYIGS LTRGSGAMVF CGSFAGLEGT 660
  661 QSLRRVSSIR RSFTTAGVKR NSIMLQVKFT VDGIIDTLRR TGTHFVHCYL LQHNAGKHTK 720
  721 YTANGSPSSA AGQVSSEEEM VNVPLLRSQL RGSQVLEAAR LHRLGFPESV PLLEFVRRFG 780
  781 LLAGDLASNK DVSVEQILAV NELDVASYRI GPSQILFRSG VLSELEAKRD VLLSDRIIQL 840
  841 QAFCRGYLAR KKMSQRRVQE LAVRCIQRNV KAFLAVRDWP WWRLLVRVTP LLNVHRTEEQ 900
  901 LKTANEELLM LRAKLEKIEC DRSEVKAENQ KLEAKLSELT VDLAEERSTA HIATERLEAE 960
  961 TAERLKLEKE LGDQTNKVKN LQETTEKLEM ELICAKSDLN GISEDEDAEN EDGVGGGVYK1020
 1021 LKYERVAREL EFTKRRLHTQ HEHDLEQLVA LKKHLEMKLS DAYEEVVEQR QVVGQWKRKA1080
 1081 QKMTNEMNDL RMLLEEQNAR NNLLEKKQRK FDAECQSLQD AVRQERQAKE RYGREKDVLQ1140
 1141 AEKFTLEQTL ADTRLDLEFK EEKLASLQRE LEEMTFGGGT EEEFAQLRRS KNETERRAKE1200
 1201 QEEELDEMAG QIQLLEQAKL RLEMTLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1715-1903] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TMRKEARRES QQRDEELEEV RGNGYKKIKA LECQLETEHE ERTLLLREKH ELERRLSSME  60
   61 DRDRVDRDAE EALNQKLRRD LRKYKALLKD AQTQLERLKA DTPGKTLIRQ LRNQLEDAES 120
  121 ARSLAMKARQ TAEAELTEVQ AMFDESHRAR NDAEERANAA HRDRAELQAQ IEENEEELGE 180
  181 LMKKYSATV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.1
Match: 1jchA
Description: Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1904-2148] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQLNTEQINV SEAEFKLNEM EAERNNLKEQ VAELQHRLDN VENLGDPSMA MMSKRLELRT  60
   61 KELESRLELE QATRARLEVQ VNRHKEALEK LQNEVTQSKM REMQAQDVIK KSQKSLRDMR 120
  121 EEFHAVSSRE QESLTRRKDL EKKVEQMESE GAALKNDLRL ALQRIADLQQ AMEEEGEEEL 180
  181 SESDESLSSV GSISDLEDRL RPVHVKRSSQ QSLNGSIGGG GGSVVSSTRT VVFEKDDNSP 240
  241 RNNAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle