YRC Public Data Repository - Protein Structure Prediction

Protein:	RRM2
Organism:	Homo sapiens
Length:	389 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RRM2.

Description	E-value	Query Range	Subject Range
RIR2_MACFA - Ribonucleoside-diphosphate reductase subunit M2 OS=Macaca fascicularis GN=RRM2 PE=2 SV=1	0.0	[1..389]	[1..389]
gi\|50745023 - gi\|50745023\|ref\|XP_419948.1\| PREDICTED: similar to Ribonucleoside-diphosphate reductase M2 chain (Ri...	0.0	[1..389]	[675..1058]
gi\|76630259 - gi\|76630259\|ref\|XP_584910.2\| PREDICTED: ribonucleotide reductase M2 polypeptide isoform 1 [Bos tauru...	0.0	[1..389]	[1..389]
RIR2_MOUSE - Ribonucleoside-diphosphate reductase subunit M2 OS=Mus musculus GN=Rrm2 PE=1 SV=1	0.0	[1..389]	[1..390]
gi\|73979721 - gi\|73979721\|ref\|XP_540076.2\| PREDICTED: similar to Ribonucleoside-diphosphate reductase M2 chain (Ri...	0.0	[1..389]	[1..394]
RIR2_RAT - Ribonucleoside-diphosphate reductase subunit M2 OS=Rattus norvegicus GN=Rrm2 PE=2 SV=1	0.0	[1..389]	[1..390]
RIR2_MESAU - Ribonucleoside-diphosphate reductase subunit M2 OS=Mesocricetus auratus GN=RRM2 PE=2 SV=1	0.0	[1..389]	[1..386]
gi\|89268988, gi\|... - gi\|89269815\|emb\|CAJ81580.1\| ribonucleotide reductase m2 polypeptide [Xenopus tropicalis], gi\|8926898...	0.0	[1..389]	[1..386]

Back

Predicted Domain #1

Region A:
Residues: [1-389]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT  60
   61 KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK 120
  121 PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI 180
  181 DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF 240
  241 ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE 300
  301 QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN 360
  361 FFEKRVGEYQ RMGVMSSPTE NSFTLDADF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	147.0
Match:	1h0nA
Description:	Ribonucleotide reductase R2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	12.7205287868529	bayes_pls_golite062009
ribonucleoside-diphosphate reductase activity	12.6679910771829	bayes_pls_golite062009
oxidoreductase activity, acting on CH or CH2 groups	12.0783326936172	bayes_pls_golite062009
class I ribonucleotide reductase activity	7.27682621818194	bayes_pls_golite062009
binding	2.38747290927526	bayes_pls_golite062009
nucleic acid binding	1.65619019230429	bayes_pls_golite062009
DNA binding	1.60520679245579	bayes_pls_golite062009
protein binding	1.35559475972187	bayes_pls_golite062009
ion binding	0.214820110894452	bayes_pls_golite062009
cation binding	0.203880627974907	bayes_pls_golite062009
metal ion binding	0.203880627974907	bayes_pls_golite062009
catalytic activity	0.197328811494233	bayes_pls_golite062009
transition metal ion binding	0.168785605665701	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: