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Protein Overview: RRM2

General Information:
Name(s) found: RRM2 [HGNC (HUGO)]
Description(s) found:
Found 38 descriptions.
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  • ribonucleotide reductase M2 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 389 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT  60
   61 KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK 120
  121 PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI 180
  181 DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF 240
  241 ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE 300
  301 QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN 360
  361 FFEKRVGEYQ RMGVMSSPTE NSFTLDADF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..389] PSI-BLAST 147.0 Ribonucleotide reductase R2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
    		•  12.7205287868529 bayes_pls_golite062009
  • ribonucleoside-diphosphate reductase activity
    		•  12.6679910771829 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH or CH2 groups
    		•  12.0783326936172 bayes_pls_golite062009
  • class I ribonucleotide reductase activity
    		•  7.27682621818194 bayes_pls_golite062009
  • binding
    		•  2.38747290927526 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.65619019230429 bayes_pls_golite062009
  • DNA binding
    		•  1.60520679245579 bayes_pls_golite062009
  • protein binding
    		•  1.35559475972187 bayes_pls_golite062009
  • ion binding
    		•  0.214820110894452 bayes_pls_golite062009
  • cation binding
    		•  0.203880627974907 bayes_pls_golite062009
  • metal ion binding
    		•  0.203880627974907 bayes_pls_golite062009
  • catalytic activity
    		•  0.197328811494233 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.168785605665701 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.63

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle