YRC Public Data Repository - Protein Structure Prediction

Protein:	NUDT12
Organism:	Homo sapiens
Length:	462 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NUDT12.

Description	E-value	Query Range	Subject Range
gi\|115621182, gi... - gi\|115951148\|ref\|XP_001197526.1\| PREDICTED: similar to ankyrin 2,3/unc44 [Strongylocentrotus purpura...	8.0E-53	[2..229]	[159..411]
gi\|66847484, gi\|... - gi\|70990006\|ref\|XP_749852.1\| Pfs, NACHT and Ankyrin domain protein [Aspergillus fumigatus Af293], gi...	1.0E-52	[2..238]	[1242..1485]
gi\|109078130 - gi\|109078130\|ref\|XP_001099246.1\| PREDICTED: similar to nudix -type motif 12 [Macaca mulatta]	4.0E-52	[1..462]	[1..462]
NUD12_MACFA - Peroxisomal NADH pyrophosphatase NUDT12 OS=Macaca fascicularis GN=NUDT12 PE=2 SV=1	7.0E-52	[1..462]	[1..462]
NUD12_PONAB - Peroxisomal NADH pyrophosphatase NUDT12 OS=Pongo abelii GN=NUDT12 PE=2 SV=1 NUD12_PONPY - Peroxisomal NADH pyrophosphatase NUDT12 - Pongo pygmaeus (Orangutan)	5.0E-51	[1..462]	[1..462]
gi\|108868779, gi... - gi\|157106769\|ref\|XP_001649474.1\| ankyrin 2,3/unc44 [Aedes aegypti], gi\|108868779\|gb\|EAT33004.1\| anky...	1.0E-50	[2..280]	[10..295]
gi\|74190805 - gi\|74190805\|dbj\|BAE28190.1\| unnamed protein product [Mus musculus]	2.0E-50	[1..462]	[1..462]

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Predicted Domain #1

Region A:
Residues: [1-286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVKRSLKQ EIVTQFHCSA AEGDIAKLTG ILSHSPSLLN ETSENGWTAL MYAARNGHPE  60
   61 IVQFLLEKGC DRSIVNKSRQ TALDIAVFWG YKHIANLLAT AKGGKKPWFL TNEVEECENY 120
  121 FSKTLLDRKS EKRNNSDWLL AKESHPATVF ILFSDLNPLV TLGGNKESFQ QPEVRLCQLN 180
  181 YTDIKDYLAQ PEKITLIFLG VELEIKDKLL NYAGEVPREE EDGLVAWFAL GIDPIAAEEF 240
  241 KQRHENCYFL HPPMPALLQL KEKEAGVVAQ ARSVLAWHSR YKFCPT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.0
Match:	1n11A
Description:	Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.60916417202222	bayes_pls_golite062009
transcription regulator activity	1.96661500497314	bayes_pls_golite062009
protein binding	1.64872738860757	bayes_pls_golite062009
nucleic acid binding	1.49110562730354	bayes_pls_golite062009
DNA binding	1.45095271799218	bayes_pls_golite062009
transcription factor binding	0.98703590879307	bayes_pls_golite062009
transcription factor activity	0.983432487244216	bayes_pls_golite062009
structural molecule activity	0.813461709396912	bayes_pls_golite062009
transcription activator activity	0.175680165424368	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [287-462]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CGNATKIEEG GYKRLCLKED CPSLNGVHNT SYPRVDPVVI MQVIHPDGTK CLLGRQKRFP  60
   61 PGMFTCLAGF IEPGETIEDA VRREVEEESG VKVGHVQYVA CQPWPMPSSL MIGCLALAVS 120
  121 TEIKVDKNEI EDARWFTREQ VLDVLTKGKQ QAFFVPPSRA IAHQLIKHWI RINPNL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.0
Match:	1vk6A
Description:	Crystal structure of NADH pyrophosphatase (1790429) from Escherichia coli k12 at 2.20 A resolution
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: