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View Structure Prediction Details

Protein: TINAGL1
Organism: Homo sapiens
Length: 467 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TINAGL1.

Description E-value Query
Range
Subject
Range
TINAL_MOUSE - Tubulointerstitial nephritis antigen-like OS=Mus musculus GN=Tinagl1 PE=1 SV=1
0.0 [1..467] [1..466]
gi|114555298 - gi|114555298|ref|XP_524645.2| PREDICTED: P3ECSL [Pan troglodytes]
0.0 [1..467] [206..678]
TINAL_RAT - Tubulointerstitial nephritis antigen-like OS=Rattus norvegicus GN=Tinagl1 PE=2 SV=1
0.0 [1..467] [1..467]
gi|73950477 - gi|73950477|ref|XP_535330.2| PREDICTED: similar to P3ECSL [Canis familiaris]
0.0 [1..466] [84..549]
gi|76611074 - gi|76611074|ref|XP_887401.1| PREDICTED: similar to oxidized-LDL responsive gene 2 isoform 2 [Bos tau...
0.0 [21..467] [88..534]
gi|6009533, gi|1... - gi|6009533|dbj|BAA84949.1| tubulointerstitial nephritis antigen [Homo sapiens], pir||JC7189 tubuloin...
9.0E-94 [17..463] [28..474]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWRCPLGLLL LLPLAGHLAL GAQQGRGRRE LAPGLHLRGI RDAGGRYCQE QDLCCRGRAD  60
   61 DCALPYLGAI CYCDLFCNRT VSDCCPDFWD FCLGVPPPFP PIQGCMHGGR IY

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.13
Match: 1couA
Description: Anticoagulant protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.99681272788262 bayes_pls_golite062009
protein binding 1.08930094117342 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [113-467]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVLGTYWDNC NRCTCQENRQ WQCDQEPCLV DPDMIKAINQ GNYGWQAGNH SAFWGMTLDE  60
   61 GIRYRLGTIR PSSSVMNMHE IYTVLNPGEV LPTAFEASEK WPNLIHEPLD QGNCAGSWAF 120
  121 STAAVASDRV SIHSLGHMTP VLSPQNLLSC DTHQQQGCRG GRLDGAWWFL RRRGVVSDHC 180
  181 YPFSGRERDE AGPAPPCMMH SRAMGRGKRQ ATAHCPNSYV NNNDIYQVTP VYRLGSNDKE 240
  241 IMKELMENGP VQALMEVHED FFLYKGGIYS HTPVSLGRPE RYRRHGTHSV KITGWGEETL 300
  301 PDGRTLKYWT AANSWGPAWG ERGHFRIVRG VNECDIESFV LGVWGRVGME DMGHH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 65.0
Match: 1pbhA
Description: CRYSTAL STRUCTURE OF HUMAN RECOMBINANT PROCATHEPSIN B AT 3.2 ANGSTROM RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.90619850296986 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.64381885397949 bayes_pls_golite062009
endopeptidase activity 3.75054525912786 bayes_pls_golite062009
hydrolase activity 3.74079711298952 bayes_pls_golite062009
cysteine-type peptidase activity 2.71117522993364 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.49113376575534 bayes_pls_golite062009
transporter activity 1.21845572420504 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
transmembrane transporter activity 1.00091316610003 bayes_pls_golite062009
protein binding 0.874003454509364 bayes_pls_golite062009
substrate-specific transporter activity 0.739265134609622 bayes_pls_golite062009
small conjugating protein-specific protease activity 0.649171767629235 bayes_pls_golite062009
thiolester hydrolase activity 0.59115205419466 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.491415920643992 bayes_pls_golite062009
kininogen binding 0.41283715939055 bayes_pls_golite062009
molecular transducer activity 0.26868506520228 bayes_pls_golite062009
signal transducer activity 0.26868506520228 bayes_pls_golite062009
active transmembrane transporter activity 0.193338880082314 bayes_pls_golite062009
ubiquitin-specific protease activity 0.0101379718864654 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle