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View Structure Prediction Details

Protein: SF3A1
Organism: Homo sapiens
Length: 793 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SF3A1.

Description E-value Query
Range
Subject
Range
SF3A1_BOVIN - Splicing factor 3A subunit 1 OS=Bos taurus GN=SF3A1 PE=2 SV=1
2.0E-74 [1..793] [1..793]
gi|73995011 - gi|73995011|ref|XP_534733.2| PREDICTED: similar to Splicing factor 3 subunit 1 (Spliceosome associat...
3.0E-74 [1..793] [1..793]
gi|34878996, gi|... - gi|34878996|ref|XP_223566.2| PREDICTED: similar to Splicing factor 3 subunit 1 (SF3a120) [Rattus nor...
4.0E-74 [20..793] [20..791]
gi|109093828 - gi|109093828|ref|XP_001109090.1| PREDICTED: splicing factor 3a, subunit 1, 120kDa isoform 3 [Macaca ...
5.0E-74 [1..793] [1..793]
gi|114685836 - gi|114685836|ref|XP_515067.2| PREDICTED: splicing factor 3a, subunit 1, 120kDa isoform 3 [Pan troglo...
1.0E-73 [1..793] [1..793]
gi|26326219, gi|... - gi|34576561|ref|NP_080451.3| splicing factor 3a, subunit 1 [Mus musculus], gi|26326219|dbj|BAC26853....
6.0E-73 [1..793] [1..791]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAGPVQAVP PPPPVPTEPK QPTEEEASSK EDSAPSKPVV GIIYPPPEVR NIVDKTASFV  60
   61 ARNGPEFEAR IRQNEINNPK FNFLNPNDPY HAYYRHKVSE FKEGKAQEPS AA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.221849
Match: 2dt6A
Description: No description for 2dt6A was found.

Predicted Domain #2
Region A:
Residues: [113-276]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPKVMQQQQQ TTQQQLPQKV QAQVIQETIV PKEPPPEFEF IADPPSISAF DLDVVKLTAQ  60
   61 FVARNGRQFL TQLMQKEQRN YQFDFLRPQH SLFNYFTKLV EQYTKILIPP KGLFSKLKKE 120
  121 AENPREVLDQ VCYRVEWAKF QERERKKEEE EKEKERVAYA QIDW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.09691
Match: 2dt7B
Description: No description for 2dt7B was found.

Predicted Domain #3
Region A:
Residues: [277-512]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDFVVVETVD FQPNEQGNFP PPTTPEELGA RILIQERYEK FGESEEVEME VESDEEDDKQ  60
   61 EKAEEPPSQL DQDTQVQDMD EGSDDEEEGQ KVPPPPETPM PPPLPPTPDQ VIVRKDYDPK 120
  121 ASKPLPPAPA PDEYLVSPIT GEKIPASKMQ EHMRIGLLDP RWLEQRDRSI REKQSDDEVY 180
  181 APGLDIESSL KQLAERRTDI FGVEETAIGK KIGEEEIQKP EEKVTWDGHS GSMART

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [513-674]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQAAQANITL QEQIEAIHKA KGLVPEDDTK EKIGPSKPNE IPQQPPPPSS ATNIPSSAPP  60
   61 ITSVPRPPTM PPPVRTTVVS AVPVMPRPPM ASVVRLPPGS VIAPMPPIIH APRINVVPMP 120
  121 PSAPPIMAPR PPPMIVPTAF VPAPPVAPVP APAPMPPVHP PP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [675-793]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PMEDEPTSKK LKTEDSLMPE EEFLRRNKGP VSIKVQVPNM QDKTEWKLNG QVLVFTLPLT  60
   61 DQVSVIKVKI HEATGMPAGK QKLQYEGIFI KDSNSLAYYN MANGAVIHLA LKERGGRKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 1we7A
Description: Solution structure of Ubiquitin-like domain in SF3a120
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.63877637096497 bayes_pls_golite062009
RNA binding 2.5865157751042 bayes_pls_golite062009
protein binding 2.0758030814092 bayes_pls_golite062009
structural constituent of ribosome 1.967509006593 bayes_pls_golite062009
structural molecule activity 1.52853261170163 bayes_pls_golite062009
transcription regulator activity 1.11533445164506 bayes_pls_golite062009
nucleic acid binding 0.896431097217265 bayes_pls_golite062009
DNA binding 0.859811565165317 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.580815305662395 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle