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View Structure Prediction Details

Protein: SF3A1
Organism: Homo sapiens
Length: 793 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SF3A1.

Description E-value Query
Range
Subject
Range
SF3A1_BOVIN - Splicing factor 3A subunit 1 OS=Bos taurus GN=SF3A1 PE=2 SV=1
2.0E-74 [1..793] [1..793]
gi|73995011 - gi|73995011|ref|XP_534733.2| PREDICTED: similar to Splicing factor 3 subunit 1 (Spliceosome associat...
3.0E-74 [1..793] [1..793]
gi|34878996, gi|... - gi|34878996|ref|XP_223566.2| PREDICTED: similar to Splicing factor 3 subunit 1 (SF3a120) [Rattus nor...
4.0E-74 [20..793] [20..791]
gi|109093828 - gi|109093828|ref|XP_001109090.1| PREDICTED: splicing factor 3a, subunit 1, 120kDa isoform 3 [Macaca ...
5.0E-74 [1..793] [1..793]
gi|114685836 - gi|114685836|ref|XP_515067.2| PREDICTED: splicing factor 3a, subunit 1, 120kDa isoform 3 [Pan troglo...
1.0E-73 [1..793] [1..793]
gi|26326219, gi|... - gi|34576561|ref|NP_080451.3| splicing factor 3a, subunit 1 [Mus musculus], gi|26326219|dbj|BAC26853....
6.0E-73 [1..793] [1..791]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAGPVQAVP PPPPVPTEPK QPTEEEASSK EDSAPSKPVV GIIYPPPEVR NIVDKTASFV  60
   61 ARNGPEFEAR IRQNEINNPK FNFLNPNDPY HAYYRHKVSE FKEGKAQEPS AA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.221849
Match: 2dt6A
Description: No description for 2dt6A was found.

Predicted Domain #2
Region A:
Residues: [113-276]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPKVMQQQQQ TTQQQLPQKV QAQVIQETIV PKEPPPEFEF IADPPSISAF DLDVVKLTAQ  60
   61 FVARNGRQFL TQLMQKEQRN YQFDFLRPQH SLFNYFTKLV EQYTKILIPP KGLFSKLKKE 120
  121 AENPREVLDQ VCYRVEWAKF QERERKKEEE EKEKERVAYA QIDW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.09691
Match: 2dt7B
Description: No description for 2dt7B was found.

Predicted Domain #3
Region A:
Residues: [277-512]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDFVVVETVD FQPNEQGNFP PPTTPEELGA RILIQERYEK FGESEEVEME VESDEEDDKQ  60
   61 EKAEEPPSQL DQDTQVQDMD EGSDDEEEGQ KVPPPPETPM PPPLPPTPDQ VIVRKDYDPK 120
  121 ASKPLPPAPA PDEYLVSPIT GEKIPASKMQ EHMRIGLLDP RWLEQRDRSI REKQSDDEVY 180
  181 APGLDIESSL KQLAERRTDI FGVEETAIGK KIGEEEIQKP EEKVTWDGHS GSMART

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [513-674]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQAAQANITL QEQIEAIHKA KGLVPEDDTK EKIGPSKPNE IPQQPPPPSS ATNIPSSAPP  60
   61 ITSVPRPPTM PPPVRTTVVS AVPVMPRPPM ASVVRLPPGS VIAPMPPIIH APRINVVPMP 120
  121 PSAPPIMAPR PPPMIVPTAF VPAPPVAPVP APAPMPPVHP PP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [675-793]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PMEDEPTSKK LKTEDSLMPE EEFLRRNKGP VSIKVQVPNM QDKTEWKLNG QVLVFTLPLT  60
   61 DQVSVIKVKI HEATGMPAGK QKLQYEGIFI KDSNSLAYYN MANGAVIHLA LKERGGRKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 1we7A
Description: Solution structure of Ubiquitin-like domain in SF3a120
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.63877637096497 bayes_pls_golite062009
RNA binding 2.5865157751042 bayes_pls_golite062009
protein binding 2.0758030814092 bayes_pls_golite062009
structural constituent of ribosome 1.967509006593 bayes_pls_golite062009
structural molecule activity 1.52853261170163 bayes_pls_golite062009
transcription regulator activity 1.11533445164506 bayes_pls_golite062009
nucleic acid binding 0.896431097217265 bayes_pls_golite062009
DNA binding 0.859811565165317 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.580815305662395 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle