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View Structure Prediction Details

Protein: EXOSC3
Organism: Homo sapiens
Length: 275 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EXOSC3.

Description E-value Query
Range		 Subject
Range
EXOS3_BOVIN - Exosome complex component RRP40 OS=Bos taurus GN=EXOSC3 PE=2 SV=1
 1.0E-88 [1..275] [1..275]
gi|109110920 - gi|109110920|ref|XP_001114719.1| PREDICTED: exosome component 3 isoform 2 [Macaca mulatta]
 1.0E-88 [1..275] [1..275]
gi|114624602, gi... - gi|114624602|ref|XP_001170257.1| PREDICTED: exosome component 3 isoform 2 [Pan troglodytes], gi|1146...
 1.0E-88 [1..275] [1..275]
EXOS3_MOUSE - Exosome complex component RRP40 OS=Mus musculus GN=Exosc3 PE=1 SV=3
 4.0E-88 [1..275] [1..274]
gi|57094135 - gi|57094135|ref|XP_538738.1| PREDICTED: similar to Exosome complex exonuclease RRP40 (Ribosomal RNA ...
 4.0E-87 [1..275] [1..275]
gi|109476427 - gi|109476427|ref|XP_001071395.1| PREDICTED: similar to exosome component 3 [Rattus norvegicus]
 4.0E-86 [3..275] [7..283]
gi|4929673 - gi|4929673|gb|AAD34097.1|AF151860_1 CGI-102 protein [Homo sapiens]
 1.0E-69 [65..275] [10..220]
gi|50749158 - gi|50749158|ref|XP_421510.1| PREDICTED: hypothetical protein [Gallus gallus]
 2.0E-65 [13..272] [2..258]

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Predicted Domain #1
Region A:
Residues: [1-275] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEPASVAAE SLAGSRARAA RTVLGQVVLP GEELLLPEQE DAEGPGGAVE RPLSLNARAC  60
   61 SRVRVVCGPG LRRCGDRLLV TKCGRLRHKE PGSGSGGGVY WVDSQQKRYV PVKGDHVIGI 120
  121 VTAKSGDIFK VDVGGSEPAS LSYLSFEGAT KRNRPNVQVG DLIYGQFVVA NKDMEPEMVC 180
  181 IDSCGRANGM GVIGQDGLLF KVTLGLIRKL LAPDCEIIQE VGKLYPLEIV FGMNGRIWVK 240
  241 AKTIQQTLIL ANILEACEHM TSDQRKQIFS RLAES

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 90.69897
Match: 2nn6G
Description: No description for 2nn6G was found.

Predicted functions:

Term Confidence Notes
RNA binding 4.49437316734899 bayes_pls_golite062009
structural constituent of ribosome 3.89236528662255 bayes_pls_golite062009
nucleic acid binding 3.68444148122352 bayes_pls_golite062009
structural molecule activity 3.54418030121155 bayes_pls_golite062009
3'-5'-exoribonuclease activity 3.40736445988244 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 3.3097066639101 bayes_pls_golite062009
exoribonuclease activity 3.27082657120932 bayes_pls_golite062009
binding 2.8667878224392 bayes_pls_golite062009
mRNA binding 2.83121485081867 bayes_pls_golite062009
ribonuclease activity 1.89205340530046 bayes_pls_golite062009
3'-5' exonuclease activity 1.55351486913613 bayes_pls_golite062009
transcription regulator activity 1.43703138180882 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.42151567812515 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 1.35850109411274 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 1.35845277283398 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 1.35845277283398 bayes_pls_golite062009
exonuclease activity 1.25488463068335 bayes_pls_golite062009
DNA binding 1.20852534725468 bayes_pls_golite062009
protein binding 1.18834207917479 bayes_pls_golite062009
0.559294837259864 bayes_pls_golite062009
transcription factor activity 0.386248501195543 bayes_pls_golite062009
ligase activity 0.346041081217685 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.246726936182314 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.151650064901878 bayes_pls_golite062009
translation initiation factor activity 0.11625379846973 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle