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View Structure Prediction Details

Protein: CLCN3
Organism: Homo sapiens
Length: 818 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLCN3.

Description E-value Query
Range		 Subject
Range
CLCN3_MOUSE - H(+)/Cl(-) exchange transporter 3 OS=Mus musculus GN=Clcn3 PE=1 SV=2
 0.0 [1..818] [1..818]
CLCN3_RAT - H(+)/Cl(-) exchange transporter 3 OS=Rattus norvegicus GN=Clcn3 PE=2 SV=2
 0.0 [1..818] [1..818]
gi|2134911, gi|8... - gi|854102|emb|CAA55280.1| chloride channel 3 [Homo sapiens], ref|NP_001820.1| chloride channel 3 [Ho...
 0.0 [1..818] [1..820]
CLCN3_PONPY - Chloride channel protein 3 - Pongo pygmaeus (Orangutan)
CLCN3_PONAB - H(+)/Cl(-) exchange transporter 3 OS=Pongo abelii GN=CLCN3 PE=2 SV=1
 0.0 [1..818] [1..801]
gi|76660445 - gi|76660445|ref|XP_880686.1| PREDICTED: similar to chloride channel 3 isoform 4 [Bos taurus]
 0.0 [1..818] [1..818]

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Predicted Domain #1
Region A:
Residues: [1-113] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESEQLFHRG YYRNSYNSIT SASSDEELLD GAGVIMDFQT SEDDNLLDGD TAVGTHYTMT  60
   61 NGGSINSSTH LLDLLDEPIP GVGTYDDFHT IDWVREKCKD RERHRRINSK KKE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [114-640] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAWEMTKSLY DAWSGWLVVT LTGLASGALA GLIDIAADWM TDLKEGICLS ALWYNHEQCC  60
   61 WGSNETTFEE RDKCPQWKTW AELIIGQAEG PGSYIMNYIM YIFWALSFAF LAVSLVKVFA 120
  121 PYACGSGIPE IKTILSGFII RGYLGKWTLM IKTITLVLAV ASGLSLGKEG PLVHVACCCG 180
  181 NIFSYLFPKY STNEAKKREV LSAASAAGVS VAFGAPIGGV LFSLEEVSYY FPLKTLWRSF 240
  241 FAALVAAFVL RSINPFGNSR LVLFYVEYHT PWYLFELFPF ILLGVFGGLW GAFFIRANIA 300
  301 WCRRRKSTKF GKYPVLEVII VAAITAVIAF PNPYTRLNTS ELIKELFTDC GPLESSSLCD 360
  361 YRNDMNASKI VDDIPDRPAG IGVYSAIWQL CLALIFKIIM TVFTFGIKVP SGLFIPSMAI 420
  421 GAIAGRIVGI AVEQLAYYHH DWFIFKEWCE VGADCITPGL YAMVGAAACL GGVTRMTVSL 480
  481 VVIVFELTGG LEYIVPLMAA VMTSKWVGDA FGREGIYEAH IRLNGYP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.154902
Match: 1kplA
Description: Clc chloride channel
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
anion channel activity 6.77290758049983 bayes_pls_golite062009
chloride channel activity 6.77290758049983 bayes_pls_golite062009
anion transmembrane transporter activity 6.08111514985329 bayes_pls_golite062009
voltage-gated chloride channel activity 5.99544422864122 bayes_pls_golite062009
voltage-gated anion channel activity 5.99544422864122 bayes_pls_golite062009
ion transmembrane transporter activity 5.07840957725271 bayes_pls_golite062009
ion channel activity 4.93164650815682 bayes_pls_golite062009
substrate-specific channel activity 4.81149777353187 bayes_pls_golite062009
channel activity 4.78965126968592 bayes_pls_golite062009
passive transmembrane transporter activity 4.78965126968592 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.67227438984104 bayes_pls_golite062009
voltage-gated ion channel activity 4.27956097534048 bayes_pls_golite062009
voltage-gated channel activity 4.255638017629 bayes_pls_golite062009
gated channel activity 4.1072949331811 bayes_pls_golite062009
transporter activity 2.94995161862691 bayes_pls_golite062009
transmembrane transporter activity 2.84443650880263 bayes_pls_golite062009
substrate-specific transporter activity 2.82470397063503 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [641-818] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLDAKEEFTH TTLAADVMRP RRNDPPLAVL TQDNMTVDDI ENMINETSYN GFPVIMSKES  60
   61 QRLVGFALRR DLTIAIESAR KKQEGIVGSS RVCFAQHTPS LPAESPRPLK LRSILDMSPF 120
  121 TVTDHTPMEI VVDIFRKLGL RQCLVTHNGR LLGIITKKDI LRHMAQTANQ DPASIMFN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.0
Match: 2j9lA
Description: No description for 2j9lA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle