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View Structure Prediction Details

Protein: BIRC2
Organism: Homo sapiens
Length: 618 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BIRC2.

Description E-value Query
Range		 Subject
Range
gi|109108440 - gi|109108440|ref|XP_001097089.1| PREDICTED: baculoviral IAP repeat-containing protein 2 isoform 3 [M...
 0.0 [1..618] [1..618]
gi|7512288, gi|1... - pir||S68450 apoptosis inhibitor hiap-2 - human, gi|1184318|gb|AAC50372.1| inhibitor of apoptosis pr...
 0.0 [1..618] [1..618]
gi|114640067, gi... - gi|114640067|ref|XP_001152603.1| PREDICTED: baculoviral IAP repeat-containing protein 2 isoform 4 [P...
 0.0 [1..618] [1..618]
gi|55729496|emb|... - hypothetical protein [Pongo pygmaeus]
gi|55729496 - gi|55729496|emb|CAH91479.1| hypothetical protein [Pongo abelii]
 0.0 [22..618] [1..597]
gi|114158628, gi... - gi|77744923|gb|ABB02415.1| baculoviral IAP repeat-containing 2 [Canis familiaris], gi|114158628|ref|...
 0.0 [22..618] [1..597]
BIRC2_MOUSE - Baculoviral IAP repeat-containing protein 2 OS=Mus musculus GN=Birc2 PE=1 SV=1
 0.0 [1..618] [1..612]

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Predicted Domain #1
Region A:
Residues: [1-154] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKTASQRLF PGPSYQNIKS IMEDSTILSD WTNSNKQKMK YDFSCELYRM STYSTFPAGV  60
   61 PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKLGDSPI QKHKQLYPSC SFIQNLVSAS 120
  121 LGSTSKNTSP MRNSFAHSLS PTLEHSSLFS GSYS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.154902
Match: 1tw6A
Description: Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
caspase inhibitor activity 3.37793799691411 bayes_pls_golite062009
protein binding 2.82801305666365 bayes_pls_golite062009
binding 2.82472291325192 bayes_pls_golite062009
caspase regulator activity 2.78624473612776 bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity 2.43952820346737 bayes_pls_golite062009
cytoskeletal protein binding 1.24291003560785 bayes_pls_golite062009
enzyme inhibitor activity 1.18464294370673 bayes_pls_golite062009
microtubule binding 1.03349057074077 bayes_pls_golite062009
tubulin binding 1.0137804715367 bayes_pls_golite062009
enzyme regulator activity 0.515008648709161 bayes_pls_golite062009
protein dimerization activity 0.204341973906209 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.0431703651486497 bayes_pls_golite062009
small conjugating protein ligase activity 0.0242766345667098 bayes_pls_golite062009
cofactor binding 0.0023150693787124 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [155-261] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLSPNPLNSR AVEDISSSRT NPYSYAMSTE EARFLTYHMW PLTFLSPSEL ARAGFYYIGP  60
   61 GDRVACFACG GKLSNWEPKD DAMSEHRRHF PNCPFLENSL ETLRFSI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.69897
Match: 1i3oE
Description: BIR domains of XIAP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
caspase inhibitor activity 3.37793799691411 bayes_pls_golite062009
protein binding 2.82801305666365 bayes_pls_golite062009
binding 2.82472291325192 bayes_pls_golite062009
caspase regulator activity 2.78624473612776 bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity 2.43952820346737 bayes_pls_golite062009
cytoskeletal protein binding 1.24291003560785 bayes_pls_golite062009
enzyme inhibitor activity 1.18464294370673 bayes_pls_golite062009
microtubule binding 1.03349057074077 bayes_pls_golite062009
tubulin binding 1.0137804715367 bayes_pls_golite062009
enzyme regulator activity 0.515008648709161 bayes_pls_golite062009
protein dimerization activity 0.204341973906209 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.0431703651486497 bayes_pls_golite062009
small conjugating protein ligase activity 0.0242766345667098 bayes_pls_golite062009
cofactor binding 0.0023150693787124 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [262-403] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNLSMQTHAA RMRTFMYWPS SVPVQPEQLA SAGFYYVGRN DDVKCFCCDG GLRCWESGDD  60
   61 PWVEHAKWFP RCEFLIRMKG QEFVDEIQGR YPHLLEQLLS TSDTTGEENA DPPIIHFGPG 120
  121 ESSSEDAVMM NTPVVKSALE MG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.69897
Match: 1qbhA
Description: 2MIHB/C-IAP-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
caspase inhibitor activity 3.37793799691411 bayes_pls_golite062009
protein binding 2.82801305666365 bayes_pls_golite062009
binding 2.82472291325192 bayes_pls_golite062009
caspase regulator activity 2.78624473612776 bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity 2.43952820346737 bayes_pls_golite062009
cytoskeletal protein binding 1.24291003560785 bayes_pls_golite062009
enzyme inhibitor activity 1.18464294370673 bayes_pls_golite062009
microtubule binding 1.03349057074077 bayes_pls_golite062009
tubulin binding 1.0137804715367 bayes_pls_golite062009
enzyme regulator activity 0.515008648709161 bayes_pls_golite062009
protein dimerization activity 0.204341973906209 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.0431703651486497 bayes_pls_golite062009
small conjugating protein ligase activity 0.0242766345667098 bayes_pls_golite062009
cofactor binding 0.0023150693787124 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [404-500] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNRDLVKQTV QSKILTTGEN YKTVNDIVSA LLNAEDEKRE EEKEKQAEEM ASDDLSLIRK  60
   61 NRMALFQQLT CVLPILDNLL KANVINKQEH DIIKQKT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.21
Match: 2b1wA
Description: No description for 2b1wA was found.

Predicted Domain #5
Region A:
Residues: [501-618] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIPLQARELI DTILVKGNAA ANIFKNCLKE IDSTLYKNLF VDKNMKYIPT EDVSGLSLEE  60
   61 QLRRLQEERT CKVCMDKEVS VVFIPCGHLV VCQECAPSLR KCPICRGIIK GTVRTFLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 1fbvA
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 3.19631993182765 bayes_pls_golite062009
binding 3.12724619324809 bayes_pls_golite062009
molecular transducer activity 2.92323609459085 bayes_pls_golite062009
signal transducer activity 2.92323609459085 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
insulin receptor binding 1.18707666182719 bayes_pls_golite062009
receptor binding 1.09099343809921 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
protein phosphorylated amino acid binding 0.649814096718101 bayes_pls_golite062009
transcription regulator activity 0.540818657754841 bayes_pls_golite062009
SH2 domain binding 0.353553274217716 bayes_pls_golite062009
nucleic acid binding 0.352421112301971 bayes_pls_golite062009
protein complex binding 0.32615263839176 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
DNA binding 0.281643350069021 bayes_pls_golite062009
phosphoprotein binding 0.16798254471727 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle