YRC Public Data Repository - Protein Structure Prediction

Protein:	NMT2
Organism:	Homo sapiens
Length:	498 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NMT2.

Description	E-value	Query Range	Subject Range
gi\|30584349, gi\|... - gi\|60653223\|gb\|AAX29306.1\| N-myristoyltransferase 2 [synthetic construct], gi\|30584349\|gb\|AAP36423.1...	0.0	[1..498]	[1..498]
gi\|60656277, gi\|... - gi\|60656277\|gb\|AAX32702.1\| N-myristoyltransferase 2 [synthetic construct], gi\|123994345\|gb\|ABM84774.... gi\|30582887, gi\|... - gi\|30582887\|gb\|AAP35670.1\| N-myristoyltransferase 2 [Homo sapiens], gi\|13623535\|gb\|AAH06376.1\| N-myr...	0.0	[1..498]	[1..498]
NMT2_BOVIN - Glycylpeptide N-tetradecanoyltransferase 2 OS=Bos taurus GN=NMT2 PE=2 SV=1	0.0	[1..498]	[1..498]
gi\|50732429 - gi\|50732429\|ref\|XP_418632.1\| PREDICTED: similar to glycylpeptide N-tetradecanoyltransferase 2 [Gallu...	0.0	[1..498]	[1..498]
gi\|113197716, gi... - gi\|118403866\|ref\|NP_001072266.1\| hypothetical protein LOC779719 [Xenopus (Silurana) tropicalis], gi\|...	0.0	[1..498]	[1..498]
NMT2_MOUSE - Glycylpeptide N-tetradecanoyltransferase 2 OS=Mus musculus GN=Nmt2 PE=1 SV=1	0.0	[1..498]	[1..529]
gi\|147902876, gi... - gi\|49522770\|gb\|AAH74208.1\| MGC83363 protein [Xenopus laevis], gi\|147902876\|ref\|NP_001086116.1\| MGC83...	0.0	[1..498]	[1..498]
gi\|46485447, gi\|... - gi\|46485447\|ref\|NP_997473.1\| N-myristoyltransferase 2 [Rattus norvegicus], gi\|44903526\|emb\|CAF32977....	0.0	[1..498]	[1..529]
NMT2_DANRE - Glycylpeptide N-tetradecanoyltransferase 2 OS=Danio rerio GN=nmt2 PE=2 SV=2	0.0	[1..498]	[1..492]

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Predicted Domain #1

Region A:
Residues: [1-498]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK KQKRKKEKPN  60
   61 SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL LSACQGPARN IDEAAKHRYQ 120
  121 FWDTQPVPKL DEVITSHGAI EPDKDNVRQE PYSLPQGFMW DTLDLSDAEV LKELYTLLNE 180
  181 NYVEDDDNMF RFDYSPEFLL WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS 240
  241 VKKMVEINFL CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH 300
  301 RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS VRELINTYLK 360
  361 QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL SFYTLPSTVM HHPAHKSLKA 420
  421 AYSFYNIHTE TPLLDLMSDA LILAKSKGFD VFNALDLMEN KTFLEKLKFG IGDGNLQYYL 480
  481 YNWRCPGTDS EKVGLVLQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1rxtA
Description:	Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
N-acyltransferase activity	5.20638659012287	bayes_pls_golite062009
histone acetyltransferase activity	5.14370420654956	bayes_pls_golite062009
lysine N-acetyltransferase activity	5.14370420654956	bayes_pls_golite062009
N-acetyltransferase activity	4.84873027228137	bayes_pls_golite062009
acyltransferase activity	4.72881921515185	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.70793039001114	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	4.69837915971204	bayes_pls_golite062009
acetyltransferase activity	4.61906868269668	bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity	3.97737934696287	bayes_pls_golite062009
myristoyltransferase activity	3.97737934696287	bayes_pls_golite062009
transferase activity	3.5778020729894	bayes_pls_golite062009
	2.57707871269985	bayes_pls_golite062009
catalytic activity	1.97933499002461	bayes_pls_golite062009
transcription regulator activity	1.24491199731644	bayes_pls_golite062009
nucleic acid binding	1.14989009422664	bayes_pls_golite062009
binding	0.796041722115687	bayes_pls_golite062009
transcription factor binding	0.55523033135522	bayes_pls_golite062009
transcription activator activity	0.246101440580601	bayes_pls_golite062009
protein binding	0.075825416385311	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: