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View Structure Prediction Details

Protein: WWP2
Organism: Homo sapiens
Length: 870 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for WWP2.

Description E-value Query
Range		 Subject
Range
gi|2072503 - gi|2072503|gb|AAC51325.1| WWP2 [Homo sapiens]
 0.0 [1..870] [1..870]
gi|109129056 - gi|109129056|ref|XP_001101869.1| PREDICTED: WW domain containing E3 ubiquitin protein ligase 2 isofo...
 0.0 [1..870] [1..870]
gi|149038120, gi... - gi|62665221|ref|XP_214669.3| PREDICTED: similar to WW domain-containing protein 2 [Rattus norvegicus...
 0.0 [1..870] [1..870]
WWP2_MOUSE - NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Mus musculus GN=Wwp2 PE=1 SV=1
 0.0 [1..870] [1..870]
gi|55730835|emb|... - hypothetical protein [Pongo pygmaeus]
gi|55730835 - gi|55730835|emb|CAH92136.1| hypothetical protein [Pongo abelii]
 0.0 [1..870] [1..871]
gi|134085740, gi... - gi|76640795|ref|XP_871462.1| PREDICTED: similar to Nedd-4-like E3 ubiquitin-protein ligase WWP2 (WW ...
 0.0 [1..870] [1..870]
gi|73957133 - gi|73957133|ref|XP_851140.1| PREDICTED: similar to Nedd-4-like E3 ubiquitin-protein ligase WWP2 (WW ...
 0.0 [1..870] [1..922]

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Predicted Domain #1
Region A:
Residues: [1-165] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI  60
   61 GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENMQLT 120
  121 LNLQTENKGS VVSGGELTIF LDGPTVDLGN VPNGSALTDG SQLPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 2nq3A
Description: No description for 2nq3A was found.

Predicted functions:

Term Confidence Notes
binding 2.77482286467294 bayes_pls_golite062009
calcium-dependent phospholipid binding 1.9375710282475 bayes_pls_golite062009
lipid binding 1.47484095830847 bayes_pls_golite062009
protein binding 1.33917246836907 bayes_pls_golite062009
phospholipid binding 1.01018855528345 bayes_pls_golite062009
transporter activity 0.739583681946393 bayes_pls_golite062009
neurexin binding 0.72940113160582 bayes_pls_golite062009
SNARE binding 0.568661953120771 bayes_pls_golite062009
hydrolase activity 0.501946993060588 bayes_pls_golite062009
substrate-specific transporter activity 0.203141170126034 bayes_pls_golite062009
syntaxin binding 0.0269444342534992 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [166-285] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDSSGTAVAP ENRHQPPSTN CFGGRSRTHR HSGASARTTP ATGEQSPGAR SRHRQPVKNS  60
   61 GHSGLANGTV NDEPTTATDP EEPSVVGVTS PPAAPLSVTP NPNTTSLPAP ATPAEGEEPS 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.84
Match: 2j63A
Description: No description for 2j63A was found.

Predicted Domain #3
Region A:
Residues: [286-370] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSGTQQLPAA AQAPDALPAG WEQRELPNGR VYYVDHNTKT TTWERPLPPG WEKRTDPRGR  60
   61 FYYVDHNTRT TTWQRPTAEY VRNYE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.39794
Match: 1tk7A
Description: NMR structure of WW domains (WW3-4) from Suppressor of Deltex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.19063870734022 bayes_pls_golite062009
small conjugating protein ligase activity 6.90783262781184 bayes_pls_golite062009
acid-amino acid ligase activity 6.09904629433884 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 5.1950291192201 bayes_pls_golite062009
transcription regulator activity 3.2682543222543 bayes_pls_golite062009
binding 2.62219069341981 bayes_pls_golite062009
proline-rich region binding 2.34621138467934 bayes_pls_golite062009
transcription activator activity 2.28375305944516 bayes_pls_golite062009
transcription factor binding 2.18630749239417 bayes_pls_golite062009
transcription cofactor activity 2.07432061489599 bayes_pls_golite062009
transcription coactivator activity 2.02433252968502 bayes_pls_golite062009
ligase activity 1.93278509588727 bayes_pls_golite062009
histone methyltransferase activity 1.90194027965368 bayes_pls_golite062009
transcription repressor activity 1.81795522051605 bayes_pls_golite062009
protein binding 1.46903005775608 bayes_pls_golite062009
lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein methyltransferase activity 1.121001087082 bayes_pls_golite062009
transcription corepressor activity 0.911388717587011 bayes_pls_golite062009
catalytic activity 0.210712504691113 bayes_pls_golite062009
histone methyltransferase activity (H3-K36 specific) 0.173723075520888 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [371-469] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QWQSQRNQLQ GAMQHFSQRF LYQSSSASTD HDPLGPLPPG WEKRQDNGRV YYVNHNTRTT  60
   61 QWEDPRTQGM IQEPALPPGW EMKYTSEGVR YFVDHNTRT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.79
Match: 1tk7A
Description: NMR structure of WW domains (WW3-4) from Suppressor of Deltex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.10194828712949 bayes_pls_golite062009
small conjugating protein ligase activity 6.82547847405261 bayes_pls_golite062009
acid-amino acid ligase activity 6.04482261304601 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 5.16615441408338 bayes_pls_golite062009
transcription regulator activity 3.182048695645 bayes_pls_golite062009
binding 2.56070278040924 bayes_pls_golite062009
transcription activator activity 2.05338377709657 bayes_pls_golite062009
transcription factor binding 1.94857953695695 bayes_pls_golite062009
proline-rich region binding 1.9352397980246 bayes_pls_golite062009
ligase activity 1.92115554795958 bayes_pls_golite062009
transcription cofactor activity 1.79381302696181 bayes_pls_golite062009
transcription repressor activity 1.7678419433602 bayes_pls_golite062009
transcription coactivator activity 1.67777735708173 bayes_pls_golite062009
histone methyltransferase activity 1.67021314973391 bayes_pls_golite062009
protein binding 1.37024347977003 bayes_pls_golite062009
protein methyltransferase activity 0.9455445085372 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 0.863094487787088 bayes_pls_golite062009
lysine N-methyltransferase activity 0.863094487787088 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 0.863094487787088 bayes_pls_golite062009
transcription corepressor activity 0.782679886083722 bayes_pls_golite062009
catalytic activity 0.231344568578849 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [470-870] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTFKDPRPGF ESGTKQGSPG AYDRSFRWKY HQFRFLCHSN ALPSHVKISV SRQTLFEDSF  60
   61 QQIMNMKPYD LRRRLYIIMR GEEGLDYGGI AREWFFLLSH EVLNPMYCLF EYAGKNNYCL 120
  121 QINPASSINP DHLTYFRFIG RFIAMALYHG KFIDTGFTLP FYKRMLNKRP TLKDLESIDP 180
  181 EFYNSIVWIK ENNLEECGLE LYFIQDMEIL GKVTTHELKE GGESIRVTEE NKEEYIMLLT 240
  241 DWRFTRGVEE QTKAFLDGFN EVAPLEWLRY FDEKELELML CGMQEIDMSD WQKSTIYRHY 300
  301 TKNSKQIQWF WQVVKEMDNE KRIRLLQFVT GTCRLPVGGF AELIGSNGPQ KFCIDKVGKE 360
  361 TWLPRSHTCF NRLDLPPYKS YEQLREKLLY AIEETEGFGQ E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 154.0
Match: 1nd7A
Description: Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 11.7414753295465 bayes_pls_golite062009
small conjugating protein ligase activity 11.4871643691645 bayes_pls_golite062009
acid-amino acid ligase activity 10.4323719338452 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 9.13168684685485 bayes_pls_golite062009
ligase activity 5.34807997732606 bayes_pls_golite062009
proline-rich region binding 2.8338032434061 bayes_pls_golite062009
sodium channel inhibitor activity 2.81182200437095 bayes_pls_golite062009
binding 2.51893471705946 bayes_pls_golite062009
transcription regulator activity 2.32249912875549 bayes_pls_golite062009
ion channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
DNA binding 1.96906809911381 bayes_pls_golite062009
nucleic acid binding 1.82016488092232 bayes_pls_golite062009
phosphothreonine binding 1.40065636224804 bayes_pls_golite062009
phosphoserine binding 1.40065636224804 bayes_pls_golite062009
protein binding 1.39373180706125 bayes_pls_golite062009
transcription repressor activity 1.38110732864799 bayes_pls_golite062009
catalytic activity 1.15152367676155 bayes_pls_golite062009
receptor binding 0.8335024106655 bayes_pls_golite062009
transcription factor binding 0.803487897091874 bayes_pls_golite062009
ubiquitin binding 0.60123113960943 bayes_pls_golite062009
ubiquitin-ubiquitin ligase activity 0.598436219078807 bayes_pls_golite062009
small conjugating protein binding 0.33937847204197 bayes_pls_golite062009
sodium channel regulator activity 0.325435827772996 bayes_pls_golite062009
nuclear hormone receptor binding 0.204781102077891 bayes_pls_golite062009
channel regulator activity 0.072778668515899 bayes_pls_golite062009
0.051942165438844 bayes_pls_golite062009
transcription activator activity 0.0310258834625421 bayes_pls_golite062009
hormone receptor binding 0.02403431201602 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle