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View Structure Prediction Details

Protein: PSMD11
Organism: Homo sapiens
Length: 422 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PSMD11.

Description E-value Query
Range
Subject
Range
gi|109488638 - gi|109488638|ref|XP_220754.3| PREDICTED: similar to 26S proteasome non-ATPase regulatory subunit 11 ...
2.0E-84 [1..422] [78..499]
gi|74193694 - gi|74193694|dbj|BAE22795.1| unnamed protein product [Mus musculus]
1.0E-78 [1..422] [1..422]
gi|62901920 - gi|62901920|gb|AAY18911.1| unknown [synthetic construct]
4.0E-78 [2..422] [26..446]
gi|2150046 - gi|2150046|gb|AAB58732.1| 26S proteasome subunit 9 [Homo sapiens]
7.0E-78 [1..422] [1..422]

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Predicted Domain #1
Region A:
Residues: [1-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAAVVEFQ RAQSLLSTDR EASIDILHSI VKRDIQENDE EAVQVKEQSI LELGSLLAKT  60
   61 GQAAELGGLL KYVRPFLNSI SKAKAARLVR SLLDLFLDME A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [102-249]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATGQEVELCL ECIEWAKSEK RTFLRQALEA RLVSLYFDTK RYQEALHLGS QLLRELKKMD  60
   61 DKALLVEVQL LESKTYHALS NLPKARAALT SARTTANAIY CPPKLQATLD MQSGIIHAAE 120
  121 EKDWKTAYSY FYEAFEGYDS IDSPKAIT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1na0A
Description: Designed protein cTPR3
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [250-319]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLKYMLLCKI MLNTPEDVQA LVSGKLALRY AGRQTEALKC VAQASKNRSL ADFEKALTDY  60
   61 RAELRDDPII 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [320-422]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STHLAKLYDN LLEQNLIRVI EPFSRVQIEH ISSLIKLSKA DVERKLSQMI LDKKFHGILD  60
   61 QGEGVLIIFD EPPVDKTYEA ALETIQNMSK VVDSLYNKAK KLT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.50995556050336 bayes_pls_golite062009
nucleic acid binding 3.38144578566524 bayes_pls_golite062009
binding 3.33026160538031 bayes_pls_golite062009
DNA binding 3.30822066787723 bayes_pls_golite062009
transcription factor activity 2.60537570879007 bayes_pls_golite062009
hydrolase activity 2.30467124306022 bayes_pls_golite062009
structural constituent of ribosome 1.46680509390433 bayes_pls_golite062009
sequence-specific DNA binding 1.32971938164691 bayes_pls_golite062009
transcription activator activity 1.08566311616647 bayes_pls_golite062009
transcription repressor activity 0.95491822926452 bayes_pls_golite062009
protein binding 0.653872239015235 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.42135864069093 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.136726704233672 bayes_pls_golite062009
small conjugating protein ligase activity 0.118016217031359 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle