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View Structure Prediction Details

Protein: ZFPL1
Organism: Homo sapiens
Length: 310 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ZFPL1.

Description E-value Query
Range
Subject
Range
gi|55636347 - gi|55636347|ref|XP_508542.1| PREDICTED: zinc finger protein-like 1 isoform 2 [Pan troglodytes]
7.0E-97 [1..310] [1..310]
gi|4165025 - gi|4165025|gb|AAD08644.1| zinc-finger protein MCG4 [Homo sapiens]
2.0E-96 [1..310] [1..310]
ZFPL1_DANRE - Zinc finger protein-like 1 OS=Danio rerio GN=zfpl1 PE=2 SV=1
3.0E-95 [1..308] [1..315]
CE21934 - status:Confirmed UniProt:Q9N4Y9 protein_id:AAF60574.1
5.0E-92 [1..307] [1..299]
gi|57100393 - gi|57100393|ref|XP_540871.1| PREDICTED: similar to zinc finger protein-like 1 [Canis familiaris]
2.0E-91 [1..310] [1..312]
gi|109105543 - gi|109105543|ref|XP_001114544.1| PREDICTED: similar to zinc finger protein-like 1 [Macaca mulatta]
2.0E-91 [1..310] [1..310]
ZFPL1_MOUSE - Zinc finger protein-like 1 OS=Mus musculus GN=Zfpl1 PE=1 SV=1
7.0E-90 [1..310] [1..310]
ZFPL1_CAEBR - Zinc finger protein-like 1 homolog OS=Caenorhabditis briggsae GN=CBG06644 PE=3 SV=1
2.0E-89 [1..307] [1..309]
ZFPL1_BOVIN - Zinc finger protein-like 1 OS=Bos taurus GN=ZFPL1 PE=2 SV=1
7.0E-89 [1..310] [1..312]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLCKCPKRK VTNLFCFEHR VNVCEHCLVA NHAKCIVQSY LQWLQDSDYN PNCRLCNIPL  60
   61 ASRETTRLVC YDLFHWACLN ERAAQLPRNT APAGYQCPSC NGPIFPPT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 1jm7A
Description: brca1 RING domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
nucleic acid binding 2.01888784395048 bayes_pls_golite062009
DNA binding 2.00904221080834 bayes_pls_golite062009
protein binding 1.5975811408548 bayes_pls_golite062009
transcription factor activity 1.22579085356684 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
small conjugating protein ligase activity 1.00637609953328 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.81824834538312 bayes_pls_golite062009
transcription repressor activity 0.350170315296021 bayes_pls_golite062009
acid-amino acid ligase activity 0.302877642467793 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
ligase activity 0.144761439114831 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
transcription activator activity 0.126093965701234 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [109-310]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLAGPVASAL REKLATVNWA RAGLGLPLID EVVSPEPEPL NTSDFSDWSS FNASSTPGPE  60
   61 EVDSASAAPA FYSQAPRPPA SPGRPEQHTV IHMGNPEPLT HAPRKVYDTR DDDRTPGLHG 120
  121 DCDDDKYRRR PALGWLARLL RSRAGSRKRP LTLLQRAGLL LLLGLLGFLA LLALMSRLGR 180
  181 AAADSDPNLD PLMNPHIRVG PS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle