YRC Public Data Repository - Protein Structure Prediction

Protein:	PSMA1
Organism:	Homo sapiens
Length:	263 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PSMA1.

Description	E-value	Query Range	Subject Range
gi\|114636649 - gi\|114636649\|ref\|XP_508298.2\| PREDICTED: similar to Proteasome subunit alpha type 1 (Proteasome comp...	6.0E-73	[1..263]	[104..366]
gi\|109107255 - gi\|109107255\|ref\|XP_001089332.1\| PREDICTED: similar to Proteasome subunit alpha type 1 (Proteasome c...	6.0E-73	[1..263]	[109..371]
gi\|73988867 - gi\|73988867\|ref\|XP_534070.2\| PREDICTED: similar to Proteasome subunit alpha type 1 (Proteasome compo...	3.0E-72	[1..263]	[106..368]
PSA1_MOUSE - Proteasome subunit alpha type-1 OS=Mus musculus GN=Psma1 PE=1 SV=1	1.0E-71	[1..263]	[1..263]
PSA1_PONPY - Proteasome subunit alpha type-1 - Pongo pygmaeus (Orangutan) PSA1_PONAB - Proteasome subunit alpha type-1 OS=Pongo abelii GN=PSMA1 PE=2 SV=1	2.0E-71	[1..263]	[1..263]
PSA1_RAT - Proteasome subunit alpha type-1 OS=Rattus norvegicus GN=Psma1 PE=1 SV=2	2.0E-71	[1..263]	[1..263]
PSA1_BOVIN - Proteasome subunit alpha type-1 OS=Bos taurus GN=PSMA1 PE=1 SV=1	2.0E-71	[1..263]	[1..263]
PSA1_MACFA - Proteasome subunit alpha type-1 OS=Macaca fascicularis GN=PSMA1 PE=2 SV=1	2.0E-71	[1..263]	[1..263]
gi\|60653715, gi\|... - gi\|60653715\|gb\|AAX29551.1\| proteasome alpha type subunit 1 [synthetic construct], gi\|30584967\|gb\|AAP...	6.0E-71	[1..263]	[1..263]
gi\|30582133, gi\|... - gi\|30582133\|gb\|AAP35293.1\| proteasome (prosome, macropain) subunit, alpha type, 1 [Homo sapiens], gi... gi\|61361727, gi\|... - gi\|61361732\|gb\|AAX42094.1\| proteasome subunit alpha type 1 [synthetic construct], gi\|61361727\|gb\|AAX...	7.0E-71	[1..263]	[1..263]

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Predicted Domain #1

Region A:
Residues: [1-263]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK RAQSELAAHQ  60
   61 KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD RPLPVSRLVS LIGSKTQIPT 120
  121 QRYGRRPYGV GLLIAGYDDM GPHIFQTCPS ANYFDCRAMS IGARSQSART YLERHMSEFM 180
  181 ECNLNELVKH GLRALRETLP AEQDLTTKNV SIGIVGKDLE FTIYDDDDVS PFLEGLEERP 240
  241 QRKAQPAQPA DEPAEKADEP MEH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.30103
Match:	1iruF
Description:	Proteasome alpha subunit (non-catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
binding	1.75265921676176	bayes_pls_golite062009
nucleic acid binding	1.39216781236247	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: