YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|28559065, gi\|...
Organism:	Homo sapiens
Length:	845 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|28559065, gi|....

Description	E-value	Query Range	Subject Range
gi\|119596761, gi... - gi\|5748522\|emb\|CAB53071.1\| DNA (cytosine-5-)-methyltransferase 3 beta [Homo sapiens], gi\|28559061\|re...	0.0	[13..845]	[1..833]
gi\|109092382 - gi\|109092382\|ref\|XP_001107440.1\| PREDICTED: DNA (cytosine-5-)-methyltransferase 3 beta isoform 3 [Ma...	0.0	[1..845]	[1..846]
gi\|114681758 - gi\|114681758\|ref\|XP_514580.2\| PREDICTED: DNA cytosine-5 methyltransferase 3 beta [Pan troglodytes]	0.0	[3..845]	[182..1046]
gi\|31074163 - gi\|31074163\|gb\|AAP20552.1\| DNA cytosine-5 methyltransferase 3b isoform 1 [Bos taurus]	0.0	[13..826]	[1..825]
gi\|109471073 - gi\|109471073\|ref\|XP_001061821.1\| PREDICTED: similar to DNA methyltransferase 3B isoform 3 [Rattus no...	0.0	[1..845]	[1..855]
gi\|6449472, gi\|1... - gi\|6449472\|gb\|AAC40179.2\| DNA cytosine-5 methyltransferase 3B2 [Mus musculus], gi\|172088101\|ref\|NP_0...	0.0	[13..845]	[1..839]

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Predicted Domain #1

Region A:
Residues: [1-222]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPSPEPPSL ESMKGDTRHL NGEEDAGGRE DSILVNGACS DQSSDSPPIL EAIRTPEIRG  60
   61 RRSSSRLSKR EVSSLLSYTQ DLTGDGDGED GDGSDTPVMP KLFRETRTRS ESPAVRTRNN 120
  121 NSVSSRERHR PSPRSTRGRQ GRNHVDESPV EFPATRSLRR RATASAGTPW PSPPSSYLTI 180
  181 DLTDDTEDTH GTPQSSSTPY ARLAQDSQQG GMESPQVEAD SG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [223-404]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP AMVVSWKATS KRQAMSGMRW VQWFGDGKFS  60
   61 EVSADKLVAL GLFSQHFNLA TFNKLVSYRK AMYHALEKAR VRAGKTFPSS PGDSLEDQLK 120
  121 PMLEWAHGGF KPTGIEGLKP NNTQPENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR 180
  181 GD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.522879
Match:	1khcA
Description:	DNA methyltransferase DNMT3B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	7.32955324136098	bayes_pls_golite062009
DNA (cytosine-5-)-methyltransferase activity	5.05440120599055	bayes_pls_golite062009
DNA-methyltransferase activity	4.57248514274229	bayes_pls_golite062009
methylated histone residue binding	3.99360930536438	bayes_pls_golite062009
histone methyltransferase activity	3.58146193288239	bayes_pls_golite062009
transcription regulator activity	3.34067645460735	bayes_pls_golite062009
unmethylated CpG binding	3.31276815221906	bayes_pls_golite062009
transcription repressor activity	3.21000367413295	bayes_pls_golite062009
protein methyltransferase activity	3.0892691305178	bayes_pls_golite062009
binding	3.03932294945523	bayes_pls_golite062009
protein binding	2.81959915474598	bayes_pls_golite062009
histone binding	2.53075587257882	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	2.42481282100188	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	2.42481282100188	bayes_pls_golite062009
lysine N-methyltransferase activity	2.42481282100188	bayes_pls_golite062009
nucleic acid binding	2.39870293911569	bayes_pls_golite062009
DNA binding	2.38812251097879	bayes_pls_golite062009
N-methyltransferase activity	2.35081504375623	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.18489564426455	bayes_pls_golite062009
transcription corepressor activity	1.65392797012899	bayes_pls_golite062009
transcription factor binding	1.49481919243505	bayes_pls_golite062009
methyltransferase activity	1.45012620929102	bayes_pls_golite062009
transcription factor activity	1.41108699101741	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.37282797213354	bayes_pls_golite062009
transcription cofactor activity	1.36802409360413	bayes_pls_golite062009
chromatin binding	0.8915883636553	bayes_pls_golite062009
histone methyltransferase activity (H3-K36 specific)	0.668498662418847	bayes_pls_golite062009
retinoid X receptor binding	0.56323697625529	bayes_pls_golite062009
retinoic acid receptor binding	0.52209845652926	bayes_pls_golite062009
transcription activator activity	0.262486595331603	bayes_pls_golite062009
histone methyltransferase activity (H4-K20 specific)	0.227288548958153	bayes_pls_golite062009
sequence-specific DNA binding	0.141502107934206	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [405-739]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDQSREQMAS DVANNKSSLE DGCLSCGRKN PVSFHPLFEG GLCQTCRDRF LELFYMYDDD  60
   61 GYQSYCTVCC EGRELLLCSN TSCCRCFCVE CLEVLVGTGT AAEAKLQEPW SCYMCLPQRC 120
  121 HGVLRRRKDW NVRLQAFFTS DTGLEYEAPK LYPAIPAARR RPIRVLSLFD GIATGYLVLK 180
  181 ELGIKVGKYV ASEVCEESIA VGTVKHEGNI KYVNDVRNIT KKNIEEWGPF DLVIGGSPCN 240
  241 DLSNVNPARK GLYEGTGRLF FEFYHLLNYS RPKEGDDRPF FWMFENVVAM KVGDKRDISR 300
  301 FLECNPVMID AIKVSAAHRA RYFWGNLPGM NRPVI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.39794
Match:	2pv0B
Description:	No description for 2pv0B was found.

Predicted Domain #4

Region A:
Residues: [740-845]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASKNDKLELQ DCLEYNRIAK LKKVQTITTK SNSIKQGKNQ LFPVVMNGKE DVLWCTELER  60
   61 IFGFPVHYTD VSNMGRGARQ KLLGRSWSVP VIRHLFAPLK DYFACE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	59.045757
Match:	1dctA
Description:	DNA methylase HaeIII
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: