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View Structure Prediction Details

Protein: EIF3CL, EIF3C
Organism: Homo sapiens
Length: 913 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EIF3CL, EIF3C.

Description E-value Query
Range
Subject
Range
gi|109459395, gi... - gi|109462864|ref|XP_001079906.1| PREDICTED: similar to eukaryotic translation initiation factor 3, s...
0.0 [1..913] [108..1018]
gi|1931584 - gi|1931584|gb|AAC27674.1| eIF-3 p110 subunit [Homo sapiens]
0.0 [1..913] [1..913]
IF38_PONPY - Eukaryotic translation initiation factor 3 subunit 8 - Pongo pygmaeus (Orangutan)
EIF3C_PONAB - Eukaryotic translation initiation factor 3 subunit C OS=Pongo abelii GN=EIF3C PE=2 SV=1
0.0 [1..913] [1..913]
gi|73958588 - gi|73958588|ref|XP_536923.2| PREDICTED: similar to eukaryotic translation initiation factor 3, subun...
0.0 [1..913] [1..913]
EIF3C_BOVIN - Eukaryotic translation initiation factor 3 subunit C OS=Bos taurus GN=EIF3C PE=2 SV=1
0.0 [1..913] [1..912]
gi|19263839 - gi|19263839|gb|AAH25032.1| Eukaryotic translation initiation factor 3, subunit C [Mus musculus]
0.0 [1..913] [1..911]
EIF3C_DANRE - Eukaryotic translation initiation factor 3 subunit C OS=Danio rerio GN=eif3c PE=1 SV=1
0.0 [1..909] [1..912]
EIF3C_XENTR - Eukaryotic translation initiation factor 3 subunit C OS=Xenopus tropicalis GN=eif3c PE=2 SV=1
0.0 [1..913] [1..922]

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Predicted Domain #1
Region A:
Residues: [1-100]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR SAKDKRFEEL  60
   61 TNLIRTIRNA MKIRDVTKCL EEFELLGKAY GKAKSIVDKE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.221849
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #2
Region A:
Residues: [101-463]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVPRFYIRIL ADLEDYLNEL WEDKEGKKKM NKNNAKALST LRQKIRKYNR DFESHITSYK  60
   61 QNPEQSADED AEKNEEDSEG SSDEDEDEDG VSAATFLKKK SEAPSGESRK FLKKMDDEDE 120
  121 DSEDSEDDED WDTGSTSSDS DSEEEEGKQT ALASRFLKKA PTTDEDKKAA EKKREDKAKK 180
  181 KHDRKSKRLD EEEEDNEGGE WERVRGGVPL VKEKPKMFAK GTEITHAVVI KKLNEILQAR 240
  241 GKKGTDRAAQ IELLQLLVQI AAENNLGEGV IVKIKFNIIA SLYDYNPNLA TYMKPEMWGK 300
  301 CLDCINELMD ILFANPNIFV GENILEESEN LHNADQPLRV RGCILTLVER MDEEFTKIMQ 360
  361 NTD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [464-558]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHSQEYVEHL KDEAQVCAII ERVQRYLEEK GTTEEVCRIY LLRILHTYYK FDYKAHQRQL  60
   61 TPPEGSSKSE QDQAENEGED SAVLMERLCK YIYAK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [559-721]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRTDRIRTCA ILCHIYHHAL HSRWYQARDL MLMSHLQDNI QHADPPVQIL YNRTMVQLGI  60
   61 CAFRQGLTKD AHNALLDIQS SGRAKELLGQ GLLLRSLQER NQEQEKVERR RQVPFHLHIN 120
  121 LELLECVYLV SAMLLEIPYM AAHESDARRR MISKQFHHQL RVG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [722-913]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERQPLLGPPE SMREHVVAAS KAMKMGDWKT CHSFIINEKM NGKVWDLFPE ADKVRTMLVR  60
   61 KIQEESLRTY LFTYSSVYDS ISMETLSDMF ELDLPTVHSI ISKMIINEEL MASLDQPTQT 120
  121 VVMHRTEPTA QQNLALQLAE KLGSLVENNE RVFDHKQGTY GGYFRDQKDG YRKNEGYMRR 180
  181 GGYRQQQSQT AY

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.14
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.85334044543318 bayes_pls_golite062009
nucleic acid binding 2.8293727459515 bayes_pls_golite062009
DNA binding 2.66906990480864 bayes_pls_golite062009
binding 2.5888309899403 bayes_pls_golite062009
transcription factor activity 1.97506348695089 bayes_pls_golite062009
protein binding 0.933833716716586 bayes_pls_golite062009
structural constituent of ribosome 0.764002516817766 bayes_pls_golite062009
structural molecule activity 0.756450227832198 bayes_pls_golite062009
sequence-specific DNA binding 0.665091289283954 bayes_pls_golite062009
transcription activator activity 0.542530812773621 bayes_pls_golite062009
transcription repressor activity 0.423955395883599 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle