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View Structure Prediction Details

Protein: gi|2827203, gi|1...
Organism: Homo sapiens
Length: 978 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|2827203, gi|1....

Description E-value Query
Range
Subject
Range
gi|114614019 - gi|114614019|ref|XP_001151693.1| PREDICTED: general transcription factor II, i isoform 8 [Pan troglo...
0.0 [1..978] [1..978]
gi|73957635, gi|... - gi|73957635|ref|XP_856663.1| PREDICTED: similar to general transcription factor II, i isoform 2 isof...
0.0 [1..978] [1..979]
GTF2I - general transcription factor II, i
0.0 [1..978] [1..998]
gi|17223644, gi|... - gi|17223644|gb|AAK49786.1| transcription factor TFII-I-beta [Mus musculus], gi|148687504|gb|EDL19451...
0.0 [1..978] [1..979]
gi|76653756 - gi|76653756|ref|XP_886987.1| PREDICTED: similar to general transcription factor II, i isoform 2 isof...
0.0 [1..978] [1..979]
GTF2I_RAT - General transcription factor II-I OS=Rattus norvegicus GN=Gtf2i PE=1 SV=2
0.0 [1..978] [1..979]

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Predicted Domain #1
Region A:
Residues: [1-18]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQVAMSTLP VEDEESSE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [19-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRMVVTFLMS ALESMCKELA KSKAEVACIA VYETDVFVVG TERGRAFVNT RKDFQKDFVK  60
   61 YCVEEEEKAA EMHKMKS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [96-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTQANRMSVD AVEIETLRKT VEDYFCFCYG KALGKSTVVP VPYEKMLRDQ SAVVVQGLPE  60
   61 GVAFKHPENY DLATLKWILE NKAGISFIIK RPFLEPKKHV G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.045757
Match: 2d9bA
Description: No description for 2d9bA was found.

Predicted Domain #4
Region A:
Residues: [197-262]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRVMVTDADR SILSPGGSCG PIKVKTEPTE DSGISLEMAA VTVKEESEDP DYYQYNIQGS  60
   61 HHSSEG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [263-469]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEGTEMEVPA EDSTQHVPSE TSEDPEVEVT IEDDDYSPPS KRPKANELPQ PPVPEPANAG  60
   61 KRKVREFNFE KWNARITDLR KQVEELFERK YAQAIKAKGP VTIPYPLFQS HVEDLYVEGL 120
  121 PEGIPFRRPS TYGIPRLERI LLAKERIRFV IKKHELLNST REDLQLDKPA SGVKEEWYAR 180
  181 ITKLRKMVDQ LFCKKFAEAL GSTEAKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 2dn4A
Description: No description for 2dn4A was found.

Predicted Domain #6
Region A:
Residues: [470-539]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPYQKFEAHP NDLYVEGLPE NIPFRSPSWY GIPRLEKIIQ VGNRIKFVIK RPELLTHSTT  60
   61 EVTQPRTNTP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [540-705]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKEDWNVRIT KLRKQVEEIF NLKFAQALGL TEAVKVPYPV FESNPEFLYV EGLPEGIPFR  60
   61 SPTWFGIPRL ERIVRGSNKI KFVVKKPELV ISYLPPGMAS KINTKALQSP KRPRSPGSNS 120
  121 KVPEIEVTVE GPNNNNPQTS AVRTPTQTNG SNVPFKPRGR EFSFEA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.59
Match: 2ed2A
Description: No description for 2ed2A was found.

Predicted Domain #8
Region A:
Residues: [706-804]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WNAKITDLKQ KVENLFNEKC GEALGLKQAV KVPFALFESF PEDFYVEGLP EGVPFRRPST  60
   61 FGIPRLEKIL RNKAKIKFII KKPEMFETAI KESTSSKSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.154902
Match: 1q60A
Description: Solution Structure of RSGI RUH-004, a GTF2I domain in Mouse cDNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.31986990828723 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 4.02258915980722 bayes_pls_golite062009
DNA binding 4.01598187073916 bayes_pls_golite062009
nucleic acid binding 3.9329721501879 bayes_pls_golite062009
transcription factor activity 3.83217404681534 bayes_pls_golite062009
binding 3.0325775548747 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.76277877142766 bayes_pls_golite062009
protein binding 1.48651016577672 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.91960306002172 bayes_pls_golite062009
mitogen-activated protein kinase binding 0.245342655759921 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [805-978]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRKINSSPNV NTTASGVEDL NIIQVTIPDD DNERLSKVEK ARQLREQVND LFSRKFGEAI  60
   61 GMGFPVKVPY RKITINPGCV VVDGMPPGVS FKAPSYLEIS SMRRILDSAE FIKFTVIRPF 120
  121 PGLVINNQLV DQSESEGPVI QESAEPSQLE VPATEEIKET DGSSQIKQEP DPTW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.69897
Match: 2ejeA
Description: No description for 2ejeA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle